Seda Yilmaz Semerci; Aslan Babayigit; Burcu Cebeci; Gokhan Buyukkale; Merih Cetinkaya
Volume 19, Issue 8 , August 2017, , Pages 1-5
Abstract
Introduction: Hydrops fetalis (HF) secondary to cytomegalovirus (CMV) is a rare but potentially fatal entity in neonates. This study aimed at providing data for diagnosis, management, and prevention of CMV associated HF in neonates. Herein, a case of non-immune hydrops fetalis (NIHF) associated with ...
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Introduction: Hydrops fetalis (HF) secondary to cytomegalovirus (CMV) is a rare but potentially fatal entity in neonates. This study aimed at providing data for diagnosis, management, and prevention of CMV associated HF in neonates. Herein, a case of non-immune hydrops fetalis (NIHF) associated with CMV infection is described and a review of the literature is presented.Case Presentation: A female neonate was born at 373/7 weeks of gestational age with clinical findings of HF in Istanbul, Turkey, during year 2015. The infant was admitted to the Neonatal Intensive Care Unit (NICU) due to respiratory distress. The CMV Ig M was positive for both the baby and the mother. Polymerase chain reaction (PCR) demonstrated 6640 copies of CMV in the urine sample. Therefore, CMV infection was considered as the main cause of NIHF and ganciclovir therapy was initiated. As the patient responded well and survived, to the best of our knowledge, this is the first long-term survived case of CMV associated HF.Conclusions: Congenital CMV infection should be kept in mind as a seldom and life-threatening cause of NIHF. Because serologic tests are not sensitive, antenatal sonographical, postnatal clinical and laboratory findings are crucial for accurate diagnosis and early treatment. All these cautions may be associated with for a better prognosis.
Caixia Wang; Shaoyong Luan; Ming Li; Ruiyun Zhang; Xiuxia Chen
Volume 19, Issue 3 , March 2017, , Pages 1-7
Abstract
Background: The exact interacting factor that response to the infection for neonatal sepsis is still needed to urgently to be disclosed.Objectives: This research was aimed to explore the potential biomarkers and illuminate the underlying molecular mechanisms associated with neonatal sepsis via identifying ...
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Background: The exact interacting factor that response to the infection for neonatal sepsis is still needed to urgently to be disclosed.Objectives: This research was aimed to explore the potential biomarkers and illuminate the underlying molecular mechanisms associated with neonatal sepsis via identifying differential modules (DMs).Methods: This is a case-control bioinformatics analysis using already published microarray data of neonatal sepsis. This study was conducted in Qingdao, China from September 2015 to May 2016. We recruited the gene expression profile of neonatal sepsis from the Array Express database (http://www.ebi.ac.uk/arrayexpress) under the accessing number of E-GEOD-25504, which included 27 neonatal samples with a confirmed blood culture-positive test for sepsis (bacterial infected cases) as well as 35 matched controls. Meanwhile, the human protein-protein interaction (PPI) data was collected from the database of Search Tool for the Retrieval ofInteracting Genes/Proteins (STRING, http://string-db.org). All of the data was preprocessed. Then, the differential co expression network (DCN) was constructed by integrating co-expression analysis and differential expression analysis. Next, a systemic module searching strategy, which contained seed genes selection, module searching and refinement of modules, was performed by select DMs.Results: Starting from the gene expression data and PPI data, the DCN that included 430 edges (covering 324 nodes) was constructed, in which each edge was assigned a weight value. From the DCN, we selected a total of 16 seed genes. Starting from these seed genes, a total of 3 modules were identified from the DCN based on the systemic module algorithm. Of them, only one module (Module 3) was considered as DM under P < 0.05. This DM was involved in the progress of ribosome biogenesis in eukaryotes.Conclusions: In the present study, we identified a key gene RPS16 and a significant module involved in ribosome biogenesis in eukaryotes that were related to neonatal sepsis, which might be potential biomarkers for early detection and therapy for neonatal sepsis
