Overexpression of Argonaute HIWI Gene in Colorectal Cancer Stem Cells and Colorectal Cancerous Tissue

Karim Mohamed Abdalla Ziyada; Donya Vatanzadeh; Asghar Beigi Harchegegani; Eisa Tahmasbpour Marzouni; Mahdi Ghatrehsamani; Issa Layali; Mohammad Mahdi Jaafarzadeh; Saeid Rahmanzadeh

Volume 25, Issue 3 , 2023

  Background: Post-treatment nursing care is essential for patients with venous malformations (VMs) after they have undergone treatment. Effective post-treatment nursing care requires adequate resources, effective communication, patient compliance, and addressing psychological distress. However, the clinical ...  Read More

Effect of Insulin Resistance and Role of Plasma Adiponectin Level in Susceptibility to Colorectal Cancer

Mostafa Vahedian; Seyed Jalal Eshagh Hoseini; amir hamta; mohammadreza saadati; Hamid Farahani

Volume 24, Issue 4 , 2022

  Background: Despite clinical and basic different investigations, the role of plasma adipokines, such as adiponectin as a precise predictor of the risk of colorectal cancer (CRC) is still conflicting. Aim: This study investigated the association between CRC and insulin resistance, obesity, and plasma ...  Read More

Association of MiR-149 with Nutritional Risk Assessment and Postoperative Complications of Patients with Colorectal Cancer

Lin Lin; Feipeng Xu; Caijin Zhou; Zhenhao Quan; Haiping Jiang

Volume 23, Issue 12 , 2021

  Background: MiRNAs play an important role in the development of colorectal cancer (CRC); however, there is little evidence of miRNAs in the screening of the nutritional risks of patients with CRC. Objectives: This study aimed to explore the role of preoperative miR-149 in nutritional screening of patients ...  Read More

Methylation Status of miR-200b Promoter in Colorectal Polyp and Adenocarcinoma Tissues

Sanaz Savabkar; Shiva Irani; Masoud Alebouyeh; Reza Mirfakhraie; Ehsan Nazemalhosseini Mojarad; Mohammad reza Zali; Hamid Asadzadeh aghdaei

Volume 23, Issue 4 , 2021

  Background: Aberrant DNA methylation is a common molecular feature in colorectal cancer (CRC). Hypermethylation of miR-200b promoter, as an epigenetic factor, is involved in CRC tumorigenesis. The methylation status of miR-200b has been examined in CRC and adjacent normal tissues.  Objectives: ...  Read More

Promotion of Extrinsic Apoptosis Pathway in HCT-116 Human Colorectal Cancer Cell Line by Sodium Butyrate as Histone Deacetylase Inhibitor

Ainaz Mashayekhi; Flora Forouzesh; Mohammadreza Mashayekhi

Volume 23, Issue 1 , 2021

  Background: Colorectal cancer (CRC) has already been considered the fourth leading cause of mortality worldwide as the genes involved in apoptotic pathways and alterations of reversible epigenetic have an important role in the progression of CRC.      Objectives: The current study ...  Read More

miR-214 sensitizes human colorectal cancer cells to doxorubicin by p53 targeting

Li Wang; Peng Jiang; Chenhui Qu; Xuefeng Li; Lei Wang; Chunhong Wei

Volume 22, Issue 12 , 2020

  Objectives: This study aimed to investigate the potential function of miR-214 in the apoptosis induction by targeting p53 in human colorectal cancer cells (CRC) in combination with doxorubicin (DOX). Methods: miR-214 mimics were transfected to HT-29 CRC cells. Following that, the transfected cells ...  Read More

Identification of a Novel Genetic Signature in Staging of Colorectal Cancer: A Bayesian Approach

Fatemeh Mohammadzadeh; Ebrahim Hajizadeh; Aliakbar Rasekhi; Sadegh Azimzadeh Jamalkandi

Volume 21, Issue 5 , 2019, Pages 1-9

  Background: Tumor stage is one of the most reliable prognostic factors in the clinical characterization of colorectal cancer. The identification of genes associated with tumor staging may facilitate the personalized molecular diagnosis and treatment along with better risk stratification in colorectal ...  Read More

Clinical and Genetic Characterization of Familial Adenomatous Polyposis: An Iranian Population Study

Seyed Kazem Mirinezhad; Seyed Yaqoob Moaddab; Kourosh Masnadi Shirazi; Morteza Jabbarpour Bonyadi; Amir Taher Eftekharsadat; Sosan Mir Najead Grami; Mohammad Hossein Somi

Volume 20, Issue 4 , 2018, Pages 1-6

  Background: Familial adenomatous polyposis (FAP) is an inherited autosomal dominant disorder, which can develop into cancer in early adulthood (100%) and is a result of germline mutations in the adenomatous polyposis coli (APC) genes.Objectives: Identify APC germline mutations and assessed relationships ...  Read More