Experimental Study on the Anti-tumor and Pro-apoptotic Effects of Paeonol in Human Gliomas

Qiang Fu; Dong Hai Liu; Zi Xuan Li; Xiao Peng Zheng; Cynthia Mutemwa; Elvis Agbo

Volume 25, Issue 4 , 2023

  Background: Current studies have demonstrated the anti-cancer effects of paeonol in some tumors; however, its effect on gliomas remains unknown. Objectives: This study aimed to investigate the anti-tumor effect of paeonol in human glioma tissues and cells including its effect and connection with apoptosis ...  Read More

Effect of Dexmedetomidine on Oxidative Stress Response and Expression of Intracellular Adhesion Factor-1 (ICAM-1) and S100B in Patients with Traumatic Brain Injury

Peng Zhao; Yunfeng Cui; Xinyu Li

Volume 23, Issue 10 , 2021

  Background: To study the effect of dexmedetomidine on oxidative stress response and the expression of intracellular adhesion factor-1 (ICAM-1) and S100B in patients with traumatic brain injury (TBI). Objectives: This study aimed to discusses the effects of dexmedetomidine on oxidative stress response ...  Read More

Effect of Adenosine Injection Following Cerebral Reperfusion Ischemia on A1AR Gene Expression and Apoptosis in Brain Hippocampal Tissue of Male Wistar Rats

Atossa Jozaei; Monireh Movahedi; Maryam Khosravi; Fereshteh Golab

Volume 21, Issue 12 , 2019, Pages 1-8

  Background: Apoptosis is a programmed cell death that occurs due to various factors such as reperfusion ischemia. As a purinergic receptor, A1AR acts as an oxidative stress sensor and an antioxidant during reperfusion ischemia.Objectives: The purpose of the present study was to investigate the effect ...  Read More

Phytochemical Contents of Salvia grossheimii SOSN. Species Extract and Its Protective Effect on Alcohol-Induced Fatty Liver in Rats

Seyed Morteza Hosseini; Mostafa Asadbegy; Roya Karamian; Siamak Yari

Volume 21, Issue 11 , 2019, Pages 1-7

  Background: Researchers are interested in finding new agents with natural sources to cure oxidant-induced diseases.Objectives: The study aimed at determining the antioxidant potential and protective effect of S. grossheimii extract against alcohol- induced fatty liver.Methods: This experimental study ...  Read More

Antidepressant and Anxiolytic Effects of Geraniol in Mice: The Possible Role of Oxidative Stress and Apoptosis

Alireza Majdi; Seyed Hojjat Hosseini; Mehrdad Roozbeh; Alireza Mohammadi

Volume 21, Issue 6 , 2019, Pages 1-9

  Background: Depression is a severe mental disorder. Current antidepressants are effective in only one-half to one-third of the patients. Besides, these medications might bring about adverse effects. Therefore, the need for newer anti-depressant medications or complementary compounds is utterly felt.Objectives: ...  Read More

The Protective Effect of Hydroalcoholic Extract of the Southern Maidenhair Fern (Adiantum capillus-veneris) on the Depression and Anxiety Caused by Chronic Stress in Adult Male Mice: An Experimental Randomized Study

Jafar Ahmadpoor; Saeid Valipour Chahardahcheric; Mahbubeh Setorki

Volume 21, Issue 3 , 2019, Pages 1-8

  Background: Antioxidant compounds are novel approaches in the treatment of neurological disorders.Objectives: The purpose of this study was to examine the antidepressant and anxiolytic effects of the hydroalcoholic extract of Adiantum capillus-veneris (rich in flavonoids with antioxidant properties) ...  Read More

The Effects of Heated Oils Used in Fast Food Restaurants on Metabolic, Inflammatory and Oxidative Stress Markers, Blood Pressure, and Liver Histology in Sprague-Dawley Rats

Saeed Ghobadi; Masoumeh Akhlaghi; Maral Mokhtari; Fatemeh Mohammadian

Volume 20, Issue 1 , 2018, Pages 1-9

  Background: Long and repeated heating causes multiple physical and chemical changes in oil, which may result in serious biolog- ical damages upon consumption. Objectives: This study investigated the effects of heated oils used in fast food restaurants on metabolic, inflammatory, and oxidative stress ...  Read More