Effects of N-Acetyl Cysteine on the Expression of Matrix Metalloproteinases 2 and 9 in the Lung Tissue of Rats Exposed to Cadmium

Armaghan Shirinsokhan; Zeinab Khazaei Koohpar; Najmeh Ranji; Fatemeh safari

Volume 22, Issue 11 , 2020

  Background: Cadmium (Cd) is a natural and heavy metal, which is widely widespread in the atmosphere. Studies report that environmental exposure to Cd increases the risk of various disorders, such as pulmonary diseases. On the other hand, Cd increases the reactive oxygen species (ROS), which interacts ...  Read More

Effects of Hydro-alcoholic Extract of Pumpkin Seeds on Oogenesis Pathway, Liver, and Kidney of Female Rats

samaneh motamed jahromi; sadegh niami jahromi

Volume 22, Issue 9 , 2020

  Background and Objectives: Pumpkin seed extract can be a good alternative to hormone replacement therapy since it is rich in phytoestrogens. In this regard, the present research aimed to investigate the effect of hydro-alcoholic extract of pumpkin seeds on the oogenesis pathway, liver, and kidney of ...  Read More

The Effect of Hydro-Alcoholic Extract of Pumpkin Seeds on Estrogen Levels and Kidney Markers in Adult Female Rats

Samaneh Motamed Jahromi; Sadegh Niami Jahromi

Volume 22, Issue 4 , 2020

  Background: Pumpkin seeds are rich in phytoestrogens (estrogen precursors) and can be good alternatives to synthetic estrogen therapy, without exerting destructive effects on renal and ovarian tissues. Objectives: In the present study, the effect of hydro-alcoholic extract of pumpkin seeds ...  Read More

Combined Therapy Following Spinal Cord Injury: Synergistic Neuroprotective Effects of Ceftriaxone and N-acetylcysteine

Omid Salimi; Aliasghar Mohammadvand; Abbas Ebrahimi Kalan; Mohammad Charkhpour; Javad Mahmoudi; Bohlool Habibi Asl

Volume 22, Issue 4 , 2020

  Background: Spinal Cord Injury (SCI) is one of the leading causes of severe neurological deficits worldwide. The pathophysiology of SCI includes a primary injury followed by a cascade of secondary biochemical and cellular changes. Current pharmacological options are limited for significant recovery ...  Read More

Effect of Adipose-Derived Mesenchymal Stem Cell Repair in Nicotine Model Rat: A Femoral Bone Diaphyseal Defect Study

Mahyar Riahi; Kazem Parivar; Javad Baharara; Reza Zandi

Volume 22, Issue 3 , 2020

  Background: The major function of the bone in the skeletal system is to provide structural support to the body and its vital organs. Many patients suffer from the disability to restore bone lesions following bone fractures during crashes or accidents. The use of mesenchymal stem cells such as adipose-derived ...  Read More

Curcumin Improves the Efficacy of BMSCs in Myocardial Ischemia Injury in Rat

Masoumeh Zirak Javanmard; Mehdi Rahnavard; Hamid Soraya; Mojtaba Karimipour

Volume 21, Issue 9 , 2019, Pages 1-9

  Background: Myocardial infarction can be associated with irreversal myocardial ischemia and the necrosis of the affected site of the heart. Curcumin has a protective effect on Myocardial Ischemia.Objectives: Our study aimed to combine a regenerative medicine with a traditional antioxidant effects as ...  Read More

Increased Expression of miR-1 in Fast-Twitch Skeletal Muscle in Response to Resistance Exercise

Mohammad Fathi; Reza Gharakhanlou; Masoud Soleimani; Hamid Rajabi

Volume 21, Issue 4 , 2019, Pages 1-8

  Background: The response of microRNA (miR-1), upstream regulators (Myogenic Differentiation 1 (MyoD1) and Myocyte Enhancer Factor 2C (Mef2C)), and a downstream target (Histone Deacetylase 4 (Hdac4)) to an acute bout of Resistance Exercise (RE) in Extensor Digitorum Longus (EDL) and soleus muscles has ...  Read More