Aria Kasiri; Maryam Eskandari Mehrabadi; Zahra Salemi; Danial Habibi; milad majidian dehkordi; omid jarahian; rasool karimi matloob
Volume 26, Issue 1 , 2024
Abstract
Background: Coronavirus disease 2019 (COVID-19), a severe disease caused by severe acute respiratory syndrome coronavirus 2, has a weak prognosis, and biological markers may predict disease severity.
Objectives: The present study aimed to assess the impact of vitamin D levels on COVID-19 outcomes in ...
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Background: Coronavirus disease 2019 (COVID-19), a severe disease caused by severe acute respiratory syndrome coronavirus 2, has a weak prognosis, and biological markers may predict disease severity.
Objectives: The present study aimed to assess the impact of vitamin D levels on COVID-19 outcomes in diabetic people.
Methods: The study was conducted on 160 individuals with both COVID-19 and diabetes at Amir-Al-Momenin Hospital in Arak. Participants completed a questionnaire regarding their personal information, medical history, and medication use. Arterial and venous blood samples were collected after 12 hours of fasting to perform arterial blood gas (ABG) and brachial venous fasting blood glucose tests, respectively. The samples were sent to the laboratory for analysis. Serum levels of 25-hydroxyvitamin D were measured using the ELISA method. The study groups were classified based on the obtained PO2 levels from the ABG test, indicating varying degrees of respiratory impairment.
Results: Patients were categorized as mild, moderate, or severe based on ABG test results. No significant difference was found in vitamin D levels among groups. Elevated levels of vitamin D in women and men with mild and moderate COVID-19 symptoms have been linked to a decrease in mortality rate. Nonetheless, significant correlations were observed between vitamin D and fasting blood sugar (FBS) levels in the mild and moderate groups, indicating varying relationships between vitamin D and FBS across these groups.
Conclusion: While immunizations and antiviral drugs work well against COVID-19, taking extra measures, such as vitamin D supplementation, plays a vital role in disease management.
Ali Akrami; Reza Bagheri; Mohammad Reza Akrami; Hamidreza Saeidi Borojeni
Volume 24, Issue 9 , 2022
Abstract
Background: Diffuse axonal injury (DAI) is the most prevalent nerve lesion in brain trauma. Given the known effects of erythropoietin and pentoxifylline on the reduction of cell death following hypoxia.
Objectives: The current study assessed the possible effects of a combination of erythropoietin, pentoxifylline, ...
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Background: Diffuse axonal injury (DAI) is the most prevalent nerve lesion in brain trauma. Given the known effects of erythropoietin and pentoxifylline on the reduction of cell death following hypoxia.
Objectives: The current study assessed the possible effects of a combination of erythropoietin, pentoxifylline, and vitamin D on patients' consciousness level.
Methods: The present research is a double-blind clinical trial with parallel groups addressing 64 DAI patients (average age: 26.5). The intervention group included 32 patients who, apart from the routine treatment, received a combination of erythropoietin, pentoxifylline, and vitamin D3. The control group also encompassed 32 patients who only received routine treatment. The effects of the interventions were assessed based on Glasgow Coma Scale (GCS), Glasgow Outcome Scale (GOS) scores, and hospitalization duration.
Results: The findings of the current research revealed that the GCS scores of the supplement (13.6±0.5) and control groups (12.4±1.6) were significantly different (P=0.043), being higher in the supplement group. The supplement group gained a higher GOS score compared to the controls (4.62±0.15 and 3.8±0.16, respectively, P=0.045). Moreover, a significant difference was observed in the hospitalization duration of the supplement (26.5±5.2) and control groups (21.4±3.2) (P=0.020). Nonetheless, the analysis of the extubation time and blood pressure of the two groups exhibited no substantial difference.
Conclusion: In this study, GCS and GOS improved after supplementation. The patients in the supplement group displayed a significantly shorter hospitalization duration. No significant difference was, however, detected when the tube was removed.
Samira Faraji; Rasoul Zarrin; Asma Zamanian; Reza Hajizadeh; Parvin Ayremlou; Behzad Rahimi
Volume 22, Issue 7 , 2020
Abstract
Background: Hypertension is one of the most serious global concerns since it has affected over 1.2 billion people.
Objectives: The present study aimed to determine the effect of vitamin D supplementation on blood pressure, fasting blood sugar, and lipid profile in hypertensive patients with ...
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Background: Hypertension is one of the most serious global concerns since it has affected over 1.2 billion people.
Objectives: The present study aimed to determine the effect of vitamin D supplementation on blood pressure, fasting blood sugar, and lipid profile in hypertensive patients with vitamin D deficiency.
Methods: In this double-blinded randomized placebo-controlled clinical trial study, 116 hypertensive patients (intervention and placebo groups, 58 each) with vitamin D deficiency (< 30 ng/mL with ECL) for 14 weeks, started from the beginning of autumn 2019 in Seyed-al-Shohada Educational Hospital in Urmia City. Fifty-five patients (49%) were male with the mean vitamin D 15.89 ± 5.09 ng/mL and 57 females with 17.29 ± 6.31 ng/mL. In a stratified blocked randomization scheme, the patients were randomly allocated into similar sized intervention and control groups based on body mass index (BMI), then the randomization with four block size was performed in each of strata by random allocation software. The intervention group received six doses of 50,000 IU vitamin D supplements for 6 weeks, then two supplements for two following months (one capsule per month). Blood pressure (24/h blood pressure measured by an ambulatory blood pressure monitoring device), vitamin D, FBS, and lipid profile (HDL, LDL, CL, and TG) were all measured at baseline and end of the study. Physical activity (measured by short IPAQ questionnaire), sun exposure using a questionnaire, dietary intake of vitamin D using three 24-hour recalls during the intervention, and anthropometric indices were measured at baseline, middle, and end of the study. Fifty-six patients in each group completed the study. The study was approved by the Ethics Committee of the Urmia University of Medical Sciences (ethics code: IR.UMSU.REC.1398.192).
Results: The office blood pressure, 24-h systolic blood pressure (SBP) and diastolic blood pressure (DBP), nighttime SBP and DBP were significantly reduced in the intervention group compared to the control group, whereas the reduction of daytime SBP and DBP was not statistically significant. Vitamin D supplementation significantly decreased serum triglyceride, cholesterol, and LDL levels.
Conclusions: Vitamin D supplementation had positive effects on blood pressure, triglyceride, cholesterol, and LDL levels in patients with low serum vitamin D.
Sonia Mansourian Hosseini; Soodabeh Aliashrafi; Mehrangiz Ebrahimi-Mameghani
Volume 20, Issue 10 , 2018, Pages 1-12
Abstract
Background: Due to the fact that there is evidence indicating the role of Vitamin D in non-alcoholic fatty liver disease (NAFLD) as well as insulin resistance (IR) and adipokines production, studies examining Vitamin D on the metabolic factors involving NAFLD is required. Objectives: Therefore, we aimed ...
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Background: Due to the fact that there is evidence indicating the role of Vitamin D in non-alcoholic fatty liver disease (NAFLD) as well as insulin resistance (IR) and adipokines production, studies examining Vitamin D on the metabolic factors involving NAFLD is required. Objectives: Therefore, we aimed to investigate the effect of single intramuscular injection of cholecalciferol on serum levels of Vitamin D, biochemical factors, and liver function status of women with NAFLD. Methods: This randomized controlled clinical trial was conducted on 82 NAFLD patients with Vitamin D deficiency (< 30 ng/mL), who were selected through convenience sampling from October 2015 to March 2016 in Tabriz, Iran, and were randomly assigned into an intervention (a single intramuscular injection of 600,000 IU of cholecalciferol) or control group. Before and after the study, serum glucose, insulin, 25-hydroxy Vitamin D, adiponectin, liver enzymes, calcium, phosphors and parathyroid hormone (PTH), as well as homeostasis model assessment (HOMA-IR), body composition, dietary intake, and physical activity level were assessed. Results: After one month intervention, serum 25-hydroxyvitamin D significantly increased in the intervention group vs. the con- trol (24.9 ± 17.4 vs. 9.1 ± 5.6, P = 0.003). Total body fat (TF) decreased in the intervention group (P = 0.001) while visceral fat (VF) was significantly different between the groups (P < 0.001). Adiponectin, calcium, phosphors, and PTH levels increased, while liver enzymes, insulin, and HOMA-IR decreased in both groups (P < 0.05). There were significant differences in mean changes of serum 25(OH) D, PTH, ALT, AST, ALP, and FBS between the groups after adjusting for baseline, TF and VF. Vitamin D injection did improve NAFLD severity (P = 0.01). Conclusions: Cholecalciferol injection improved Vitamin D status and hepatic steatosis.
Fariba Eslamian; Fatemeh Jahanjoo; Vahideh Toopchizadeh; Banafshe Kharrazi
Volume 20, Issue 6 , 2018, Pages 1-9
Abstract
Background: Patellofemoral pain syndrome (PFPS) is characterized by anterior knee pain due to arthralgia in the joint between the patella and femur. Many factors, including improper biomechanics and skeletal disorders, are associated with PFPS. The role of Vitamin D deficiency in the pathogenesis of ...
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Background: Patellofemoral pain syndrome (PFPS) is characterized by anterior knee pain due to arthralgia in the joint between the patella and femur. Many factors, including improper biomechanics and skeletal disorders, are associated with PFPS. The role of Vitamin D deficiency in the pathogenesis of patellar chondromalacia has been known for several years. Objectives: The aim of the present study was to determine the prevalence of Vitamin D deficiency in young people with Patellofemoral Pain Syndrome (PFPS) and compare this with the prevalence in a healthy matched control group and to determine the correlation between the occurrence of biomechanical abnormalities and serum levels of 25(OH)D in patients with PFPS. Methods: In this case-control study, 40 patients aged 15 to 40 years old with a diagnosis of PFPS, that had referred to the rehabilita- tion clinic of a university hospital in Tabriz, Iran, were selected as the case group and 40 normal subjects of the same age range were selected as the controls. Serum 25(OH)D levels were assessed, and a postural examination was performed on both groups, while the severity of knee pain, plain knee radiographs, and serum levels of calcium and phosphorous were assessed only in PFPS patients. Results: Among the 80 participants, Vitamin D deficiency (cut-off level of 25(OH)D ≤ 20 ng/mL) was observed in 55 participants (68.75%), including 35 (87.5%) patients and 20 (50%) controls, with a statistically significant difference (P < 0.001). Females had a higher prevalence of Vitamin D deficiency than males, yet the difference was not statistically significant (71.21% versus 57.14%, P = 0.348). The serum levels of Vitamin D and pain severity were significantly and inversely related in the case group (P = 0.005). Clinicaland imaging findings showed that 18 (45%) of the patients and two (5%) of the controls had abnormalities, such as genu varus, genu valgus, or patellar tracking, indicating a high coexistence of biomechanical deficits in PFPS (P < 0.001).Conclusions: Severe and moderate Vitamin D deficiencies were more prevalent in young adults with PFPS than in normal adults. Knee pain severity and joint deformities were correlated with low levels of Vitamin D in the case group. Therefore, attention to diet, vitamin supplementations, and biomechanical correction are the mainstay treatment of PFPS.
Behnaz Khazai; Rahim Vakili
Volume 19, Issue 2 , February 2017, , Pages 1-6
Abstract
Introduction: Coincided familial hypophosphatemic rickets (FHR) and Hypopituitarism is a rare condition. Growth hormone deficiency (GHD) evaluation has been advocated for refractory FHR cases, considering the possible masking effect of FHR on the former. Moreover, there has been controversial use of ...
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Introduction: Coincided familial hypophosphatemic rickets (FHR) and Hypopituitarism is a rare condition. Growth hormone deficiency (GHD) evaluation has been advocated for refractory FHR cases, considering the possible masking effect of FHR on the former. Moreover, there has been controversial use of growth hormone as an adjunct therapy in FHR.Case Presentation: A 19-month-old girl was presented with severe growth failure, refractory to 6 months of vitamin D therapy for assumed nutritional rickets. Following detection of low serum phosphate, insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein 3 (IGFBP3), phosphaturia and positive FHR family history, she was diagnosed with concomitant FHR and hypopituitarism.Conclusions: This case highlights the fact that FHR and GHD may coexist, with possible masking effect of one on the other, thereby misleading the approach, posing large impacts on therapy, which has historically been a difficult challenge in FHR patients.
