Document Type : Case reports

Authors

• Laurentiu Nedelcu ^{1, 2}
• Teodora Dumitrescu ²

¹ Department of Internal Medicine and Medical Semiology, University Transylvania, Brasov, Romania

² Department of Internal Medicine, Emergency County Hospital, Brasov, Romania

Abstract

Introduction: Gastrointestinal stromal tumors (GIST) represent less than 1% of all gastrointestinal tumors. The GIST diagnosis in a patient with a newly discovered myasthenia gravis (MG) raises the problem of evolution and treatment.
Case Presentation: We present the case of a 58-year-old patient, who has been diagnosed with MG on December 2015 at emergency clinical county hospital Brasov, Romania. After further investigations, a localized gastric GIST was discovered. The treatment was surgical (January 2016) and the one-year evolution after the surgery was without relapse. Genetic mutations in the KIT and PDGFR genes were investigated.
Conclusions: GIST may be accidentally discovered in asymptomatic patients. Genetic mutation examinations are needed in order to provide evidence. MG in association with GIST is rare and raises problems of diagnosis and treatment.

Keywords

• Gastrointestinal Stromal Tumors
• Myasthenia Gravis
• Mutations