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Primary Splenic Hodgkin’s Disease in a Patient with Chronic Granulomatous Disease, a Case Report

AUTHORS

Bita Geramizadeh 1 , * , A Alborzi 2 , M Hosseini 3 , M Ramzi 4 , HR Foroutan 5

1 Professor of Pathology, Transplant Research Center, Department of Pathology, Shiraz University of Medical Sciences, PO Box: 71345-1864, Shiraz, Fars, Iran

2 Department of Pediatric Infectious Disease, Prof. Alborzi Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

3 Department of Pathology, Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

4 Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

5 Department of Pediatric Surgery, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

How to Cite: Geramizadeh B, Alborzi A, Hosseini M, Ramzi M, Foroutan H. Primary Splenic Hodgkin’s Disease in a Patient with Chronic Granulomatous Disease, a Case Report, Iran Red Crescent Med J. 2010 ; 12(3):e95883.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 12 (3); e95883
Published Online: May 31, 2010
Article Type: Case Report
Received: July 01, 2019
Accepted: May 31, 2010

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Abstract

Here we report a 20-year-old male, a known case of chronic granulomatous disease (CGD), who presented with fever and splenomegaly. After splenectomy, primary splenic Hodgkin’s disease was diagnosed. Immunohistochemistry confirmed the diagnosis (positive CD15 and CD30). With chemotherapy, his fever was subsided and now after 6 months, he is doing well. Although primary immune deficiencies have been reported to show an increased tendency to develop malignancies, until now there has been no report of a patient with CGD and Hodgkin’s disease.

Keywords

Chronic granulomatous disease Spleen Hodgkin’s disease

© 2010, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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