IF: 0.644
REUTERS THOMSON

Serologic Activity against HTLV-I in Patients with Primary Sjögren’s Syndrome in Mashhad, an Endemic Area

AUTHORS

N Saadati 1 , * , M Taghavi 2

1 Department of Internal Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Khorasan, Iran

2 Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Khorasan, Iran

How to Cite: Saadati N, Taghavi M. Serologic Activity against HTLV-I in Patients with Primary Sjögren’s Syndrome in Mashhad, an Endemic Area, Iran Red Crescent Med J. 2010 ; 12(1):e95881.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 12 (1); e95881
Published Online: January 31, 2010
Article Type: Rapid Communication
Received: July 01, 2019
Accepted: January 31, 2010

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: There are accumulating evidences that Human T cell Leukemia Virus type I (HTLV-I) plays a part in the development of Sjögren's Syndrome (SS). This virus is endemic in some areas of the world. The objective of this study was to estimate the seroprevalence rates of anti-HTLV-I in SS patients in Mashhad and to determine whether any association between SS patients and HTLV-I could be observed.

 

Methods: We recruited 21 patients with primary SS who consecutively attended our Rheumatology Clinic in Ghaem Hospital affiliated to Mashhad University of Medical Sciences in Mashhad, Northeastern Iran during May 1, 2005 to September 30, 2008. Serum samples were screened for HTLV-I, using an enzyme-linked immunosorbent assay (ELISA). To compare the seroprevalence rates of HTLV-I found in SS patients with those in the community, we used the viral infection rates calculated for the entire population of blood donors in Mashhad by Blood Transfusion Organization.

 

Results: All patients with SS were negative by ELISA versus HTLV-I.

 

Conclusion: This study demonstrates no prevalence of positivity for HTLV-1 in SS patients in Mashhad. These data are against the role of HTLV-I in the development of SS in our region.

 

Keywords

Sjögren’s syndrome Human T cell Leukemia Virus type I (HTLV-I) Northeastern Iran

© 2010, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Fulltext

COMMENTS

LEAVE A COMMENT HERE: