Iranian Red Crescent Medical Journal

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Effect of a Neoflavonoid (Dalbergin) on T47D Breast Cancer Cell Line and mRNA Levels of p53, Bcl-2, and STAT3 Genes

Fereshte Mahdizade 1 , 2 , Bahram Goliaei 2 , * , Kazem Parivar 1 and Alireza Nikoofar 3
Authors Information
1 Department of Biology, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
2 Department of Biophysics, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
3 Department of Radiotherapy, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Red Crescent Medical Journal: 21 (4); e87175
  • Published Online: May 11, 2019
  • Article Type: Research Article
  • Received: December 8, 2018
  • Revised: March 27, 2019
  • Accepted: March 29, 2019
  • DOI: 10.5812/ircmj.87175

To Cite: Mahdizade F, Goliaei B, Parivar K, Nikoofar A. Effect of a Neoflavonoid (Dalbergin) on T47D Breast Cancer Cell Line and mRNA Levels of p53, Bcl-2, and STAT3 Genes, Iran Red Crescent Med J. Online ahead of Print ; 21(4):e87175. doi: 10.5812/ircmj.87175.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Spitale A, Mazzola P, Soldini D, Mazzucchelli L, Bordoni A. Breast cancer classification according to immunohistochemical markers: Clinicopathologic features and short-term survival analysis in a population-based study from the South of Switzerland. Ann Oncol. 2009;20(4):628-35. doi: 10.1093/annonc/mdn675. [PubMed: 19074747].
  • 2. Wu AH, Yu MC, Tseng CC, Pike MC. Epidemiology of soy exposures and breast cancer risk. Br J Cancer. 2008;98(1):9-14. doi: 10.1038/sj.bjc.6604145. [PubMed: 18182974]. [PubMed Central: PMC2359677].
  • 3. Khazaee-Pool M, Montazeri A, Majlessi F, Rahimi Foroushani A, Nedjat S, Shojaeizadeh D. Breast cancer-preventive behaviors: Exploring Iranian women's experiences. BMC Womens Health. 2014;14(1):41. doi: 10.1186/1472-6874-14-41. [PubMed: 24606758]. [PubMed Central: PMC3973958].
  • 4. Leon-Gonzalez AJ, Auger C, Schini-Kerth VB. Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy. Biochem Pharmacol. 2015;98(3):371-80. doi: 10.1016/j.bcp.2015.07.017. [PubMed: 26206193].
  • 5. Kang NJ, Shin SH, Lee HJ, Lee KW. Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis. Pharmacol Ther. 2011;130(3):310-24. doi: 10.1016/j.pharmthera.2011.02.004. [PubMed: 21356239].
  • 6. Chen D, Dou QP. Tea polyphenols and their roles in cancer prevention and chemotherapy. Int J Mol Sci. 2008;9(7):1196-206. doi: 10.3390/ijms9071196. [PubMed: 19325799]. [PubMed Central: PMC2635719].
  • 7. Choudhary D, Kushwaha P, Gautam J, Kumar P, Verma A, Kumar A, et al. Fast and long acting neoflavonoids dalbergin isolated from Dalbergia sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis: Osteoprotective effect of Dalbergin. Biomed Pharmacother. 2016;83:942-57. doi: 10.1016/j.biopha.2016.08.010. [PubMed: 27522257].
  • 8. Kong W, Sun R, Gao Y, Nan G, Yang G, Li Y. Dissociation constants and solubilities of dalbergin and nordalbergin in different solvents. J Chem Eng Data. 2015;60(9):2585-93. doi: 10.1021/acs.jced.5b00098.
  • 9. Li SR, Chen LY, Tsai JC, Tzeng JY, Tsai IL, Wang EC. New syntheses of dalbergichromene and dalbergin from vanillin via neoflavene intermediate. Tetrahedron Lett. 2007;48(12):2139-41. doi: 10.1016/j.tetlet.2007.01.117.
  • 10. Hsu S, Lewis J, Singh B, Schoenlein P, Osaki T, Athar M, et al. Green tea polyphenol targets the mitochondria in tumor cells inducing caspase 3-dependent apoptosis. Anticancer Res. 2003;23(2B):1533-9. [PubMed: 12820420].
  • 11. Kim NY, Pae HO, Oh GS, Kang TH, Kim YC, Rhew HY, et al. Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol Toxicol. 2001;88(5):261-6. [PubMed: 11393587].
  • 12. Chen J. The cell-cycle arrest and apoptotic functions of p53 in tumor initiation and progression. Cold Spring Harb Perspect Med. 2016;6(3). a026104. doi: 10.1101/cshperspect.a026104. [PubMed: 26931810]. [PubMed Central: PMC4772082].
  • 13. Pitteri SJ, Kelly-Spratt KS, Gurley KE, Kennedy J, Buson TB, Chin A, et al. Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. Cancer Res. 2011;71(15):5090-100. doi: 10.1158/0008-5472.CAN-11-0568. [PubMed: 21653680]. [PubMed Central: PMC3148311].
  • 14. Avalle L, Camporeale A, Camperi A, Poli V. STAT3 in cancer: A double edged sword. Cytokine. 2017;98:42-50. doi: 10.1016/j.cyto.2017.03.018. [PubMed: 28579221].
  • 15. Ozmen V. Breast cancer in the world and Turkey. J Breast Health. 2008;4(2):6-12.
  • 16. Hassan MS, Ansari J, Spooner D, Hussain SA. Chemotherapy for breast cancer (Review). Oncol Rep. 2010;24(5):1121-31. doi: 10.1093/nutrit/nux012. [PubMed: 20878101].
  • 17. Grosso G, Bella F, Godos J, Sciacca S, Del Rio D, Ray S, et al. Possible role of diet in cancer: Systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk. Nutr Rev. 2017;75(6):405-19. doi: 10.1093/nutrit/nux012. [PubMed: 28969358].
  • 18. Grosso G. Effects of polyphenol-rich foods on human health. Nutrients. 2018;10(8). doi: 10.3390/nu10081089. [PubMed: 30110959]. [PubMed Central: PMC6115785].
  • 19. Zhou Y, Li Y, Zhou T, Zheng J, Li S, Li HB. Dietary natural products for prevention and treatment of liver cancer. Nutrients. 2016;8(3):156. doi: 10.3390/nu8030156. [PubMed: 26978396]. [PubMed Central: PMC4808884].
  • 20. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2(12):1231-46. doi: 10.3390/nu2121231. [PubMed: 22254006]. [PubMed Central: PMC3257627].
  • 21. Bhattacharya M, Singh A, Ramrakhyani C. Dalbergia sissoo-an important medical plant. J Med Plant Res. 2014;2(2).
  • 22. Al-Snaf AE. Chemical constituents and pharmacological effects of Dalbergia sissoo - A review. IOSR J Pharm (IOSRPHR). 2017;7(2):59-71. doi: 10.9790/3013-0702015971.
  • 23. Liu BW, Wang TJ, Li LL, Zhang L, Liu YX, Feng JY, et al. Oncoprotein HBXIP induces PKM2 via transcription factor E2F1 to promote cell proliferation in ER-positive breast cancer. Acta Pharmacol Sin. 2019;40(4):530-8. doi: 10.1038/s41401-018-0015-9. [PubMed: 29925919].
  • 24. Lumachi F, Brunello A, Maruzzo M, Basso U, Basso SM. Treatment of estrogen receptor-positive breast cancer. Curr Med Chem. 2013;20(5):596-604. doi: 10.5530/pj.2018.1.7. [PubMed: 23278394].
  • 25. Nur RM, Nugroho LH. Cytotoxic activities of fractions from dioscorea bulbifera L. chloroform and methanol extracts on T47D breast cancer cells. Pharmacogn J. 2017;10(1):33-8. doi: 10.5530/pj.2018.1.7.
  • 26. Taghizadeh B, Ghavami L, Nikoofar A, Goliaei B. Equol as a potent radiosensitizer in estrogen receptor-positive and -negative human breast cancer cell lines. Breast Cancer. 2015;22(4):382-90. doi: 10.1007/s12282-013-0492-0. [PubMed: 24014377].
  • 27. He X, Arslan AD, Ho TT, Yuan C, Stampfer MR, Beck WT. Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties. Oncogenesis. 2014;3. e84. doi: 10.1038/oncsis.2013.47. [PubMed: 24418892]. [PubMed Central: PMC3940912].
  • 28. Sari S, Hashemi M, Mahdian R, Parivar K, Rezayat M. The effect of pentoxifylline on bcl-2 gene expression changes in hippocampus after ischemia-reperfusion in wistar rats by a quatitative RT-PCR method. Iran J Pharm Res. 2013;12(3):495-501. [PubMed: 24250655]. [PubMed Central: PMC3813272].
  • 29. Ren B, Li D, Si L, Ding Y, Han J, Chen X, et al. Alteronol induces cell cycle arrest and apoptosis via increased reactive oxygen species production in human breast cancer T47D cells. J Pharm Pharmacol. 2018;70(4):516-24. doi: 10.1111/jphp.12879. [PubMed: 29411391].
  • 30. Mileo AM, Miccadei S. Polyphenols as modulator of oxidative stress in cancer disease: New therapeutic strategies. Oxid Med Cell Longev. 2016;2016:6475624. doi: 10.1155/2016/6475624. [PubMed: 26649142]. [PubMed Central: PMC4663347].
  • 31. Gaikwad KK, Lee YS. Novel natural phenolic compound-based oxygen scavenging system for active packaging applications. Journal of Food Measurement and Characterization. 2016;10(3):533-8. doi: 10.1007/s11694-016-9332-1.
  • 32. Zhou Y, Zheng J, Li Y, Xu DP, Li S, Chen YM, et al. Natural polyphenols for prevention and treatment of cancer. Nutrients. 2016;8(8). doi: 10.3390/nu8080515. [PubMed: 27556486]. [PubMed Central: PMC4997428].
  • 33. Luqman S, Meena A, Singh P, Kondratyuk TP, Marler LE, Pezzuto JM, et al. Neoflavonoids and tetrahydroquinolones as possible cancer chemopreventive agents. Chem Biol Drug Des. 2012;80(4):616-24. doi: 10.1111/j.1747-0285.2012.01439.x. [PubMed: 22726671]. [PubMed Central: PMC3448855].
  • 34. Jahanafrooz Z, Motameh N, Bakhshandeh B. Comparative evaluation of silibinin effects on cell cycling and apoptosis in human breast cancer MCF-7 and T47D cell lines. Asian Pac J Cancer Prev. 2016;17(5):2661-5. [PubMed: 27268647].
  • 35. Bigdeli B, Goliaei B, Masoudi-Khoram N, Jooyan N, Nikoofar A, Rouhani M, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-94. doi: 10.1016/j.taap.2016.10.021. [PubMed: 27984132].

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