Iranian Red Crescent Medical Journal

Published by: Kowsar

Comparison of the Effects of Nigella sativa Oil and Nano-silver on Wound Healing in an Experimental Rat Model

Yalçın Turhan 1 , * , Mehmet Arıcan 1 , Zekeriya Okan Karaduman 1 , Ozan Turhal 2 , Mehmet Gamsızkan 3 , Davut Aydın 4 and Korhan Ozkan 5
Authors Information
1 Orhopaedcis and Traumatology Department, Duzce University Medical Faculty, Duzce, Turkey
2 Orthopaedics and Traumatology Department, Cizre State Hospital, Şırnak, Turkey
3 Pathology Department, Duzce University Medical Faculty, Duzce, Turkey
4 Orhopaedics and Traumatology Department, Hendek State Hospital, Sakarya, Turkey
5 Orhopaedcis and Traumatology Department, Medeniyet University, Medical Faculty, Istanbul, Turkey
Article information
  • Iranian Red Crescent Medical Journal: 21 (1); e84650
  • Published Online: January 8, 2019
  • Article Type: Research Article
  • Received: September 26, 2018
  • Revised: November 8, 2018
  • Accepted: November 13, 2018
  • DOI: 10.5812/ircmj.84650

To Cite: Turhan Y, Arıcan M, Karaduman Z O, Turhal O, Gamsızkan M, et al. Comparison of the Effects of Nigella sativa Oil and Nano-silver on Wound Healing in an Experimental Rat Model, Iran Red Crescent Med J. Online ahead of Print ; 21(1):e84650. doi: 10.5812/ircmj.84650.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003;17(4):299-305. doi: 10.1002/ptr.1309. [PubMed: 12722128].
  • 2. Awad EM. In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil. Phytomedicine. 2005;12(1-2):100-7. doi: 10.1016/j.phymed.2003.09.003. [PubMed: 15693715].
  • 3. Emeka LB, Emeka PM, Khan TM. Antimicrobial activity of Nigella sativa L. seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds. Pak J Pharm Sci. 2015;28(6):1985-90. [PubMed: 26639493].
  • 4. Javadi SMR, Hashemi M, Mohammadi Y, MamMohammadi A, Sharifi A, Makarchian HR. Synergistic effect of honey and Nigella sativa on wound healing in rats. Acta Cir Bras. 2018;33(6):518-23. doi: 10.1590/s0102-865020180060000006. [PubMed: 30020313].
  • 5. Feng QL, Wu J, Chen GQ, Cui FZ, Kim TN, Kim JO. A mechanistic study of the antibacterial effect of silver ions on Escherichia coli and Staphylococcus aureus. J Biomed Mater Res. 2000;52(4):662-8. doi: 10.1002/1097-4636(20001215)52:4<662::AID-JBM10>3.0.CO;2-3. [PubMed: 11033548].
  • 6. Liu W, Wu Y, Wang C, Li HC, Wang T, Liao CY, et al. Impact of silver nanoparticles on human cells: Effect of particle size. Nanotoxicology. 2010;4(3):319-30. doi: 10.3109/17435390.2010.483745. [PubMed: 20795913].
  • 7. Albers CE, Hofstetter W, Siebenrock KA, Landmann R, Klenke FM. In vitro cytotoxicity of silver nanoparticles on osteoblasts and osteoclasts at antibacterial concentrations. Nanotoxicology. 2013;7(1):30-6. doi: 10.3109/17435390.2011.626538. [PubMed: 22013878].
  • 8. Gopinath PM, Ranjani A, Dhanasekaran D, Thajuddin N, Archunan G, Akbarsha MA, et al. Multi-functional nano silver: A novel disruptive and theranostic agent for pathogenic organisms in real-time. Sci Rep. 2016;6:34058. doi: 10.1038/srep34058. [PubMed: 27666290]. [PubMed Central: PMC5036090].
  • 9. Ghannam SF, Korayem HE, Farghaly LM, Hosny S. The effect of chitosan nanosilver dressing versus mesenchymal stem cells on wound healing. J Africa Ass Phys Sci. 2018;6(1):23-31.
  • 10. Majeske C. Reliability of wound surface area measurements. Phys Ther. 1992;72(2):138-41. doi: 10.1093/ptj/72.2.138. [PubMed: 1549635].
  • 11. Caliskan E, Gamsizkan M, Acikgoz G, Durmus M, Toklu S, Dogrul A, et al. Intralesional treatments for hypertrophic scars: Comparison among corticosteroid, 5-fluorouracil and botulinum toxin in rabbit ear hypertrophic scar model. Eur Rev Med Pharmacol Sci. 2016;20(8):1603-8. [PubMed: 27160135].
  • 12. Upadhyay NK, Kumar R, Siddiqui MS, Gupta A. Mechanism of wound-healing activity of Hippophae rhamnoides L. leaf extract in experimental burns. Evid Based Complement Alternat Med. 2011;2011:659705. doi: 10.1093/ecam/nep189. [PubMed: 19946025]. [PubMed Central: PMC3152935].
  • 13. Nayak S, Nalabothu P, Sandiford S, Bhogadi V, Adogwa A. Evaluation of wound healing activity of Allamanda cathartica. L. and Laurus nobilis. L. extracts on rats. BMC Complement Altern Med. 2006;6:12. doi: 10.1186/1472-6882-6-12. [PubMed: 16597335]. [PubMed Central: PMC1456996].
  • 14. Chaloupka K, Malam Y, Seifalian AM. Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 2010;28(11):580-8. doi: 10.1016/j.tibtech.2010.07.006. [PubMed: 20724010].
  • 15. Martinez-Gutierrez F, Thi EP, Silverman JM, de Oliveira CC, Svensson SL, Vanden Hoek A, et al. Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles. Nanomedicine. 2012;8(3):328-36. doi: 10.1016/j.nano.2011.06.014. [PubMed: 21718674].
  • 16. Yaman I, Durmus AS, Ceribasi S, Yaman M. Effects of Nigella sativa and silver sulfadiazine on burn wound healing in rats. Veterinarni Med. 2010;55(No. 12):619-24. doi: 10.17221/2948-vetmed.
  • 17. Abu-Zinadah O. Using Nigella sativa oil to treat and heal chemical induced wound of rabbit skin. J King Abdulaziz Univ Sci. 2009;21(2):335-46. doi: 10.4197/Sci.21-2.11.
  • 18. Sarkhail P, Esmaily H, Baghaei A, Shafiee A, Abdollahi M, Khademi Y, et al. Burn healing potential of Nigella sativa seed oil in rats. Int J Pharm Sci Res. 2011;2(1):34.
  • 19. Kanter M, Coskun O, Kalayci M, Buyukbas S, Cagavi F. Neuroprotective effects of Nigella sativa on experimental spinal cord injury in rats. Hum Exp Toxicol. 2006;25(3):127-33. doi: 10.1191/0960327106ht608oa. [PubMed: 16634331].
  • 20. Rai M, Yadav A, Gade A. Silver nanoparticles as a new generation of antimicrobials. Biotechnol Adv. 2009;27(1):76-83. doi: 10.1016/j.biotechadv.2008.09.002. [PubMed: 18854209].
  • 21. Abou El-Nour KMM, Eftaiha A, Al-Warthan A, Ammar RAA. Synthesis and applications of silver nanoparticles. Arab J Chem. 2010;3(3):135-40. doi: 10.1016/j.arabjc.2010.04.008.
  • 22. Konop M, Damps T, Misicka A, Rudnicka L. Certain aspects of silver and silver nanoparticles in wound care: A minireview. J Nanomaterials. 2016;2016:1-10. doi: 10.1155/2016/7614753.
  • 23. Ding L, Shan X, Zhao X, Zha H, Chen X, Wang J, et al. Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications. Carbohydr Polym. 2017;157:1538-47. doi: 10.1016/j.carbpol.2016.11.040. [PubMed: 27987866].
  • 24. Das S, Baker AB. Biomaterials and nanotherapeutics for enhancing skin wound healing. Front Bioeng Biotechnol. 2016;4:82. doi: 10.3389/fbioe.2016.00082. [PubMed: 27843895]. [PubMed Central: PMC5087310].
  • 25. Venn RD. Reduction of postsurgical blood-replacement needs with Surgicel hemostasis. Med Times. 1965;93(10):1113-6. [PubMed: 5826774].
  • 26. Blau S, Kanof NB, Simonsen L. Absorbable hemostatic gauze Surgicel® in dermabrasion and dermatologic surgery. Acta Derm Venereol. 1960;40:358-61.
  • 27. Kang BS, Na YC, Jin YW. Comparison of the wound healing effect of cellulose and gelatin: An in vivo study. Arch Plast Surg. 2012;39(4):317-21. doi: 10.5999/aps.2012.39.4.317. [PubMed: 22872833]. [PubMed Central: PMC3408275].
  • 28. Kantipudi S, Sunkara JR, Rallabhandi M, Thonangi CV, Cholla RD, Kollu P, et al. Enhanced wound healing activity of Ag-ZnO composite NPs in Wistar Albino rats. IET Nanobiotechnol. 2018;12(4):473-8. doi: 10.1049/iet-nbt.2017.0087. [PubMed: 29768232].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments