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The Role of Vaginal Prolactin in Diagnosis of Premature Rupture of Membranes


N Kariman ORCID 1 , * , M Hedayati 2 , SH Alavi Majd 2

1 Department of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, n_kariman@yahoo.com, Iran

2 Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Iran

How to Cite: Kariman N, Hedayati M, Alavi Majd S. The Role of Vaginal Prolactin in Diagnosis of Premature Rupture of Membranes, Iran Red Crescent Med J. Online ahead of Print ; 14(6):352-357.


Iranian Red Crescent Medical Journal: 14 (6); 352-357
Article Type: Research Article
Received: October 20, 2011
Accepted: January 29, 2012




Background: Premature rupture of membranes (PROM) is one of the most common complications of pregnancy that has a major impact on pregnancy outcomes. A diagnostic tool that is non-invasive, specific and quick is needed to predict PROM. The purpose of this study was to evaluate the diagnostic power of the vaginal washing fluid prolactin for the diagnosis of premature rupture of membranes and to determine cut-off values.


Methods: A total of 114 pregnant women were recruited in this diagnostic trial. The PROM group consisted of 54 pregnant women between 20 and 41 weeks of gestation with diagnosis of confirmed PROM [amniotic fluid pooling (+) and Nitrazine paper test (+) and fernt test (+)]. The control group consisted of 60 pregnant women between 20 and 41 weeks of gestation without any complaint or complication. All patients underwent speculum examination for amniotic fluid pooling, nitrazine paper test, fern test, vaginal washing fluid prolactin sampling..


Results:Vaginal fluid concentrations of prolactin was significantly different between the two groups (P < 0.001). The sensitivity, specificity, positive and negative predictive values and accuracy were 87.03%, 75.0%, 75.80%, 86.53% and 83.33% in detecting PROM by evaluation of vaginal fluid prolactin concentration with a cut-off value of 9.50 µIU/ml, respectively.


Conclusion: The prolactin levels in the washing fluid of the posterior vaginal fornix in our experience is reliable and non-invasive diagnostic tests of PROM.


Premature rupture of membranes Prolactin Vaginal washing fluid

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