IF: 0.644

The Healing Effect of Bioglue in Articular Cartilage Defect of Femoral Condyle in Experimental Rabbit Model


N Tanideh 1 , S Dehghani Nazhvani 2 , * , F Mojtahed Jaberi 1 , D Mehrabani 1 , S Rezazadeh 1 , S Pakbaz 1 , A Tamadon 1 , B Nikahval 1


1 Stem Cell and Transgenic Technology Research Center, Department of Pharmacology, Shiraz University of Medical Sciences, Iran

2 Department of Veterinary Surgery, School of Veterinary Medicine, Shiraz University, sdehghan04@yahoo.com, Iran


Iranian Red Crescent Medical Journal: 13 (9); 629-633
Article Type: Research Article
Received: January 14, 2011
Accepted: April 25, 2011




Background: The full-thickness articular cartilage defects of knee have a poor healing capacity that may progress to osteoarthritis and need a knee replacement. This study determines the healing effect of bioglue in full-thickness articular cartilage defect of femoral condyle in rabbit.


Methods: Forty-eight male rabbits were randomly divided into four equal groups. In group A, 4 mm articular cartilage defects were created in the right and left medial femoral condyles. Then a graft from xiphoid cartilage was transferred into the defect together with a designed bioglue and the knees were closed. In group B, an articular cartilage defect was created identical to group A, but the defect size was 6 mm. In group C, 4 and 6 mm articular cartilage defects were created in the right and left medial femoral condyles respectively. The graft was transferred into the defect and the knees were stitched. In group D, articular cartilage defects were created similar to group C, just filled with bioglue and closed. The rabbits were euthanized and subgroups were defined as A1, B1, C1 and D1 after 30 days and A2, B2, C2 and D2 after 60 days. The cartilages were macroscopically and histologically investigated for any changes.


Results: Microscopic and macroscopic investigations showed that bioglue had a significant healing effect in the femoral condyle.


Conclusion: Addition of bioglue can effectively promote the healing of articular cartilage defects.



Healing Bioglue Articular Cartilage Defect Femoral Condyle Rabbit

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