IF: 0.644
REUTERS THOMSON

Correlation between HLA System and Primary Vesicoureteral Reflux

AUTHORS

S Falahatkar 1 , * , GH Mokhtari 2 , S.A Askari 2

AUTHORS INFORMATION

1 Department of Urology, Razy Hospital, falahatkar-s@yahoo.com, Iran

2 Department of Urology, Razy Hospital, Iran

How to Cite: Falahatkar S, Mokhtari G, Askari S. Correlation between HLA System and Primary Vesicoureteral Reflux, Iran Red Crescent Med J. Online ahead of Print ; 8(1):13-15.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 8 (1); 13-15
Article Type: Research Article

Crossmark

CHEKING

READ FULL TEXT
Abstract

Objectives: The polygenic mode for inheritance of vesicoureteral reflux (VUR) is a debutable issue. Our study is aimed to investigate the correlation between HLA system and VUR.
     Materials: the study included thirty patients with VUR and sixty patients from kidney donors as control group. Initially the HLA formulas of each patient were detected to racial-geographical distribution as well as common and specific antigen. Then, Relative Risk (RR) for the class 1 antigens of the HLA system was calculated and the X2 statistical test was performed for the antigens with RR>1 to establish a significant association between HLA system and VUR.
     Results: Increased frequency of the genes HLA-A9   HLA-B44 were characterized by statistical analysis (RR>1, X2>3.84)
therefore, the significant correlation was found between VUR and HLA system (P<0.05)
     Conclusion: There are significant correlation between VUR and HLA-A9 and HLA-B44.
However, more study is necessary that these genes may become markers for VUR.

Keywords

HLA system , vesicoureteral reflux, diagnostic marker

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: