Assessment of Myocardial Viability with Contrast-enhanced Magnetic Resonance Imaging and Technetium Scintigraphy

AUTHORS

Fatemeh Ghasemzadeh 1 , * , A Ghayemian 2 , R Abdi 2 , RA Mahamadpur 2

1 Department of Cardiology, Fatemeh Zahra Heart Center, Mazandaran University of Medical Sciences, dr_fa_ghasemzadeh@yahoo.com, Mazandaran, Iran

2 Department of Cardiology,Fatemeh Zahra Heart Center,Mazandaran University of Medical Sciences, Mazandaran, Iran

How to Cite: Ghasemzadeh F, Ghayemian A, Abdi R, Mahamadpur R. Assessment of Myocardial Viability with Contrast-enhanced Magnetic Resonance Imaging and Technetium Scintigraphy, Iran Red Crescent Med J. Online ahead of Print ; 11(4):450-453.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 11 (4); 450-453
Article Type: Brief Report
Received: December 10, 2008
Accepted: May 17, 2009

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Abstract

Background: In patients with coronary artery disease (CAD), assessment of viable myocardium has important prognostic implications. The aim of this study was to compare contrast-enhanced magnetic resonance imaging (ce–MRI) with single–photon emission computed tomography (SPECT), using 99mTC–sestamibi for detection of myocardial viability.

 

Methods: Twenty-seven patients with coronary artery disease and an ejection fraction (EF) <40% were enrolled. For the ce–MRI, the segmental extent of hyperenhancement (SEH) was quantified after the administration of a gadolinium–based contrast agent, and for the SPECT a 4-hour redistribution protocol was used. For the assessment of EF, we used echocardiography. Comparison of viability assessment was performed in 1458 segments.

 

Results: Agreement between two modalities was obtained in 1332 (91.4%) segments, resulting in a kappa value of 0.8. In 126 segments, we had discordant results. 102 SPECT viable segments were non-viable according to ce–MRI and 24 ce–MRI viable segments were described as non-viable by SPECT.

 

Conclusions: SPECT was comparable to ce–MRI for myocardial viability assessment, but we were not able to define which of them was superior.

Keywords

Magnetic resonance imaging Single photon emission computed tomography Myocardial viability

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