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Preemptive Effects of Lidocain on Postoperative Pain in Patients Undergoing Disc Operation: A Randomized, Double Blind, Placebo-Controlled Clinical Trial

AUTHORS

Esmail Fakharian 1 , * , MR Fazel 2 , H Tabesh 2 , SA Masoud 2

AUTHORS INFORMATION

1 Assistant Professor of Department of Neurosurgery, Trauma Research Center,Kashan University of Medical Sciences, efakharian@gmail.com, Iran

2 Department of Anesthesiology,Kashan University of Medical Sciences, Iran

How to Cite: Fakharian E, Fazel M, Tabesh H, Masoud S. Preemptive Effects of Lidocain on Postoperative Pain in Patients Undergoing Disc Operation: A Randomized, Double Blind, Placebo-Controlled Clinical Trial, Iran Red Crescent Med J. Online ahead of Print ; 11(1):37-41.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 11 (1); 37-41
Article Type: Research Article
Received: December 14, 2007
Accepted: May 17, 2008

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Abstract

Background: Postoperative pain is a major poorly managed problem in millions of operations performed all over the world each year. Since infiltration of the operative field with lidocain as a local anesthetic is very cheap, it is easily available, and there are few side effects, this study aimed to evaluate its efficacy on post-op-pain of patients undergoing open intervertebral disc surgery.

 

Methods: In this double blind clinical trial on 188 patients undergoing elective open intervertebral disc operation, the surgical incision site was infiltrated with 2 ml of 1/500,000 epinephrine for each centimeter in the control group and the same solution with 20 mg lidocain for each centimeter of the incision in the case group. Post-op-pain was measured with visual analog scale (VAS) in the 6th, 12th, 24th, and 48th hours.

 

Results: The mean age was 41.8±12.4 for the study group, and 43.5±15.6 for the control one. Statistical analysis revealed no significant difference in pain severity in females, but for males it was significant at the 6th and 24th hours. Interestingly, it was more severe in those receiving lidocain. The amount of narcotics used postoperatively revealed no significant difference in the groups.

 

Conclusion: Lidocain used locally before skin incision has no effect on reducing post-op-pain, post-op-narcotics demand, and duration of hospital stay.

 

Keywords

Disc herniation Postoperative pain Preemptive analgesia

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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