IF: 0.644
REUTERS THOMSON

Expression of Ki-67, C-erbB2 and EGFR in TCC of the urinary bladder and their correlation with tumor grading

AUTHORS

SA Shamsdin 1 , * , D Mehrabani 2 , M Hosseinzadeh 3

AUTHORS INFORMATION

1 Department of Immunology, Fasa University of Medical Sciences, shamsrozita@hotmail.com, Fars, Iran

2 Gastroenterohepathology Research Center, Shiraz University of Medical Science, Nemazee Hospital, Fars, Iran

3 Department of Pathology, Fasa University of Medical Sciences, Fars, Iran

How to Cite: Shamsdin S, Mehrabani D, Hosseinzadeh M. Expression of Ki-67, C-erbB2 and EGFR in TCC of the urinary bladder and their correlation with tumor grading, Iran Red Crescent Med J. Online ahead of Print ; 10(2):95-99.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 10 (2); 95-99
Article Type: Research Article
Received: October 31, 2007
Accepted: March 9, 2008

Crossmark

CHEKING

READ FULL TEXT
Abstract

Background: Transitional cell carcinoma (TCC) of the bladder is the most common malignancy of the urinary tract. Staging and grading of TCC of the bladder and its biomarkers can be indicators of the prognosis. This study was performed to evaluate the expression of Ki-6, EGFR and c-erbB2 in bladder TCC and their correlation with the tumor grading using immunohistochemistry method.

 

Methods: Immunohistochemical staining of paraffin blocks of 60 cases of primary TCC was performed and the results were correlated with grading of the tumor on H & E staining.  

 

Results: The expression of EGFR was significantly higher than c-erbB2 and Ki-67 in TCC of the bladder (p<0.05). This increase was higher in 3 and 4 grades for EGFR and c-erbB2 when compared with EGFR and Ki-67 (p<0.05).

 

Conclusion: Expression of EGFR and c-erbB2 is useful in the prognosis of grading and tumor aggressiveness.

Keywords

Transitional cell carcinoma Ki-67 c-erbB2 EGFR Grading Bladder

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

Full Text

Full text is available in PDF

COMMENTS

LEAVE A COMMENT HERE: