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Pattern visual evoked potential in response to monocular and binocular stimulation in normal and amblyope subjects

AUTHORS

J Heravian 1 , * , H Ostadi-Moghaddam 2 , AA Yekta 2 , H Hasanabadi 2 , M Mahjoob 2

AUTHORS INFORMATION

1 Departmet of Optometry, Paramedical Faculty, Mashhad University of Medical Sciences, Malek Abad Square, heravianj@mums.ac.ir, Korasan Razavi, Iran

2 Departmet of Optometry, Paramedical Faculty, Mashhad University of Medical Sciences, Iran

How to Cite: Heravian J, Ostadi-Moghaddam H, Yekta A, Hasanabadi H, Mahjoob M. Pattern visual evoked potential in response to monocular and binocular stimulation in normal and amblyope subjects, Iran Red Crescent Med J. Online ahead of Print ; 10(2):69-74.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 10 (2); 69-74
Article Type: Research Article
Received: September 1, 2007
Accepted: January 27, 2008

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Abstract

Background: Amblyopia is a relatively common condition with an incidence of 2-2.5% in which visual acuity through an eye is subnormal despite no overt pathology. The use of pattern visual evoked potential (P-VEP) has been the primary technique for electrophysiologically detecting amblyopia in patients unable to undergo conventional testing. This study was performed to evaluate the effectiveness of P-VEP parameters in amblyopic patients under monocular and binocular conditions.

 

Methods: Visual function was measured using P-VEP and Snellen acuity test in 30 children with amblyopia (12 strabismic and 18 anisometropic amblyopes) and 30 visually normal control subjects.

 

Results: Totally, visual evoked potentials elicited by high contrast small checkerboard patterned stimuli were significantly reduced in amplitude and prolonged in latency in amblyopic eyes. The mean intraocular amplitude difference was significantly larger in amblyopics than in normal groups. There was also no difference between the healthy eye in the amblyopic group and the control one. On binocular viewing, the amount of VEP amplitude was significantly greater in normal subjects than that in both amblyopic groups. Regarding the type of amblyopia, the mean binocular VEP amplitude as compared to that in the non-amblyopic eye was greater for the anisometropic than the strabismic groups.

 

Conclusion: In both amblyopic groups, the VEP responses were significantly reduced in amplitude and prolonged in latency. In binocular viewing, the amount of VEP amplitude was greater in normal subjects than both amblyopic groups. The mean binocular amplitude was significantly greater for the anisometropic than for the strabismic group.

 

Keywords

Ambyopia VEP Anisometropia Strabismus

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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