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Evaluation of the Efficacy of Aspirin and Low Molecular Weight Heparin in Patients with Unexplained Recurrent Spontaneous Abortions

AUTHORS

J Zolghadri 1 , F Ahmadpour 2 , * , M Momtahan 1 , Z Tavana 1 , L Foroughinia 1

AUTHORS INFORMATION

1 Department of Obstetrics and Gynecology, Shiraz University of Medical Science, Fars, Iran

2 Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, ahmadpour@sums.ac.ir, Fars, Iran

How to Cite: Zolghadri J, Ahmadpour F, Momtahan M, Tavana Z, Foroughinia L. Evaluation of the Efficacy of Aspirin and Low Molecular Weight Heparin in Patients with Unexplained Recurrent Spontaneous Abortions, Iran Red Crescent Med J. Online ahead of Print ; 12(5):548-552.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 12 (5); 548-552
Article Type: Research Article
Received: February 20, 2010
Accepted: May 24, 2010

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Abstract

Background: The roles of inflammatory cytokines and local placental thrombosis in patients with unexplained recurrent spontaneous abortion (URSA) have been shown. Since low molecular weight heparin (LMWH) and acetyl salicylic acid (ASA) have both anti-inflammatory and anti-coagulant effect, we evaluated their efficacy in patients with URSA.

 

Methods: One hundred patients with a history of URSA referring to Obstetrics Clinic affiliated to Shiraz University of Medical Sciences between 2004 and 2009 were randomly divided into two groups. Fifty patients in thromboprophylaxis group were treated with LMWH (5000 unit; twice a day), ASA (80 mg daily) and calcium supplement (500 mg daily) after detection of fetal heart beat. Another 50 patients received no thromboprophylaxis. Live birth rate, obstetrical complications, prenatal and neonatal complications and hemorrhagic side effects were recorded.

 

Results: Both groups were matched for mean age and mean number of pervious abortions. Thromboprophylaxis group had a higher rate of live birth (83.7%) in comparison to the control group (54%). No maternal or neonatal side effects were seen. There were no differences in obstetrical complications, prenatal and neonatal complications between the two groups.

 

Conclusion: Thromboprophylaxis with ASA and LMWH seems to be safe and effective in patients with URSA.

 

Keywords

Recurrent abortions Thromboprophylaxis Aspirin Heparin

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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