Iranian Red Crescent Medical Journal

Published by: Kowsar

The Effects of Natural Nano-Sized Clinoptilolite and Metformin on the Levels of Serum Glucose, Lipid Profile, and Minerals in Rats with Type 2 Diabetes Mellitus

Habib Fallahnejad 1 , Hossein Omidi 1 , Sirous Khorram 2 , Mehran Mesgari 3 , Mohammad Asghari-Jafarabadi 4 and Ali Tarighat-Esfanjani 1 , *
Authors Information
1 Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
2 Faculty of Experimental Physics, Materials Physics, Materials Science, University of Tabriz, Tabriz, Iran
3 Department of Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Statistics and Epidemiology, Tabriz University of Medical sciences, Tabriz, Iran
Article information
  • Iranian Red Crescent Medical Journal: October 2018, 20 (10); e74365
  • Published Online: October 9, 2018
  • Article Type: Research Article
  • Received: May 6, 2018
  • Revised: August 16, 2018
  • Accepted: August 24, 2018
  • DOI: 10.5812/ircmj.74365

To Cite: Fallahnejad H, Omidi H, Khorram S, Mesgari M, Asghari-Jafarabadi M, et al. The Effects of Natural Nano-Sized Clinoptilolite and Metformin on the Levels of Serum Glucose, Lipid Profile, and Minerals in Rats with Type 2 Diabetes Mellitus, Iran Red Crescent Med J. 2018 ; 20(10):e74365. doi: 10.5812/ircmj.74365.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33 Suppl 1:S62-9. doi: 10.2337/dc10-S062. [PubMed: 20042775]. [PubMed Central: PMC2797383].
  • 2. Shen GX. Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase. Can J Physiol Pharmacol. 2010;88(3):241-8. doi: 10.1139/Y10-018. [PubMed: 20393589].
  • 3. Vahid F, Shivappa N, Karamati M, Naeini AJ, Hebert JR, Davoodi SH. Association between dietary inflammatory index (DII) and risk of prediabetes: A case-control study. Appl Physiol Nutr Metab. 2017;42(4):399-404. doi: 10.1139/apnm-2016-0395. [PubMed: 28177734].
  • 4. Demoz GT, Gebremariam G, Legesse Y. The current scenario of clinical pharmacy service in the management of patients with diabetes mellitus and related complications: Review article. India J Pharm Pract. 2018;10(4):237-47. doi: 10.5530/ijopp.10.4.50.
  • 5. Roshanravan N, Alizadeh M, Hedayati M, Asghari-Jafarabadi M, Mesri Alamdari N, Anari F, et al. Effect of zinc supplementation on insulin resistance, energy and macronutrients intakes in pregnant women with impaired glucose tolerance. Iran J Public Health. 2015;44(2):211-7. [PubMed: 25905055]. [PubMed Central: PMC4401879].
  • 6. Wiernsperger N, Rapin J. Trace elements in glucometabolic disorders: An update. Diabetol Metab Syndr. 2010;2:70. doi: 10.1186/1758-5996-2-70. [PubMed: 21167072]. [PubMed Central: PMC3023745].
  • 7. Yan MK, Khalil H. Vitamin supplements in type 2 diabetes mellitus management: A review. Diabetes Metab Syndr. 2017;11 Suppl 2:S589-95. doi: 10.1016/j.dsx.2017.04.009. [PubMed: 28420574].
  • 8. Ali MK, Bullard KM, Saaddine JB, Cowie CC, Imperatore G, Gregg EW. Achievement of goals in U.S. diabetes care, 1999-2010. N Engl J Med. 2013;368(17):1613-24. doi: 10.1056/NEJMsa1213829. [PubMed: 23614587].
  • 9. Owens DR, Monnier L, Barnett AH. Future challenges and therapeutic opportunities in type 2 diabetes: Changing the paradigm of current therapy. Diabetes Obes Metab. 2017;19(10):1339-52. doi: 10.1111/dom.12977. [PubMed: 28432748]. [PubMed Central: PMC5637910].
  • 10. Ashraf H, Zare S. Preventive effects of aqueous extract of berberis integerrima bge. Root on liver injury induced by diabetes mellitus (type 1) in rats. Iran J Pharm Res. 2015;14(1):335-43. [PubMed: 25561940]. [PubMed Central: PMC4277647].
  • 11. Rashid R, Murtaza G, Khan AK, Mir S. Antioxidant and hypoglycemic effect of otostegia aucheri methanolic extract in streptozotocin-induced diabetic male long-Evans rats. Acta Pol Pharm. 2014;71(4):631-5. [PubMed: 25272889].
  • 12. Rimoli MG, Rabaioli MR, Melisi D, Curcio A, Mondello S, Mirabelli R, et al. Synthetic zeolites as a new tool for drug delivery. J Biomed Mater Res A. 2008;87(1):156-64. doi: 10.1002/jbm.a.31763. [PubMed: 18085645].
  • 13. Prvulović D, Košarčić S, Popović M, Grubor-Lajšić G. Effects of dietary hidrated aluminosilicates on growth performance and blood parameters of pigs. Cuban J Agric Sci. 2009;43(1):59-63.
  • 14. Januškevičius A, Januškevičienė G, Plungytė K. Klinoptilolitas suaugusių šunų racionuose. Vet Med Zoot. 2013;64(86). Lithuanian.
  • 15. Zarkovic N, Zarkovic K, Kralj M, Borovic S, Sabolovic S, Blazi MP, et al. Anticancer and antioxidative effects of micronized zeolite clinoptilolite. Anticancer Res. 2003;23(2B):1589-95. [PubMed: 12820427].
  • 16. Hossein-Nia B, Khorram S, Rezazadeh H, Safaiyan A, Ghiasi R, Tarighat-Esfanjani A. The effects of natural clinoptilolite and nano-sized clinoptilolite supplementation on lipid profile, food intakes and body weight in rats with streptozotocin-induced diabetes. Adv Pharm Bull. 2018;8(2):211-6. doi: 10.15171/apb.2018.025. [PubMed: 30023322]. [PubMed Central: PMC6046415].
  • 17. Hossein Nia B, Khorram S, Rezazadeh H, Safaiyan A, Tarighat-Esfanjani A. The effects of natural clinoptilolite and nano-sized clinoptilolite supplementation on glucose levels and oxidative stress in rats with type 1 diabetes. Can J Diabetes. 2018;42(1):31-5. doi: 10.1016/j.jcjd.2017.01.010. [PubMed: 28506813].
  • 18. Omidi H, Khorram S, Mesgari M, Asghari-Jafarabadi M, Tarighat-Esfanjani A. Effects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativa on oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes. Biomed Pharmacother. 2017;96:1335-40. doi: 10.1016/j.biopha.2017.11.077. [PubMed: 29169727].
  • 19. Demirel R, Yokus B, DEMİREL DE, Ketani MA, Baran MS. Effects of dietary zeolite on serum contents and feeding performance in rats. Int J Agric Biol. 2011;13(3).
  • 20. Khataee A, Bozorg S, Khorram S, Fathinia M, Hanifehpour Y, Joo SW. Conversion of natural clinoptilolite microparticles to nanorods by glow discharge plasma: A novel fe-impregnated nanocatalyst for the heterogeneous fenton process. Ind Eng Chem Res. 2013;52(51):18225-33. doi: 10.1021/ie403283n.
  • 21. Garimella S, Seshayamma V, Rao HJ, Kumar S, Kumar U, Saheb SH. Effect of Metformin on Lipid profile of type II diabetes. Int J Intg Med Sci. 2016;3(11):449-53. doi: 10.16965/ijims.2016.155.
  • 22. Pavelic K, Hadzija M. Medical applications of zeolites. Handbook of Zeolite science and technology. New York: Dekker; 2003. p. 1143-74.
  • 23. Qiu Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: A meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res. 2017;177(1):53-63. doi: 10.1007/s12011-016-0877-y. [PubMed: 27785738].
  • 24. Siddiqui K, Bawazeer N, Joy SS. Variation in macro and trace elements in progression of type 2 diabetes. ScientificWorldJournal. 2014;2014:461591. doi: 10.1155/2014/461591. [PubMed: 25162051]. [PubMed Central: PMC4138889].
  • 25. Chakraborty A, Chowdhury S, Bhattacharyya M. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract. 2011;93(1):56-62. doi: 10.1016/j.diabres.2010.11.030. [PubMed: 21146883].
  • 26. Schwaller D, Wilkens MR, Liesegang A. Zeolite A effect on calcium homeostasis in growing goats. J Anim Sci. 2016;94(4):1576-86. doi: 10.2527/jas.2015-9690. [PubMed: 27136016].
  • 27. Thilsing-Hansen T, Jorgensen RJ, Enemark JM, Larsen T. The effect of zeolite A supplementation in the dry period on periparturient calcium, phosphorus, and magnesium homeostasis. J Dairy Sci. 2002;85(7):1855-62. doi: 10.3168/jds.S0022-0302(02)74259-8. [PubMed: 12201536].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments