IF: 0.644

Prophylactic Aminophylline for Prevention of Apnea at Higher-Risk Preterm Neonates


Amir Mohammad Armanian 1 , * , Zohreh Badiee 1 , Raha Afghari 2 , Nima Salehimehr 3 , Akbar Hassanzade 4 , Soghra Sheikhzadeh 5 , Maryam Sharif Tehrani 5 , Gohar Rezvan 5


1 Department of Pediatrics, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran

2 Isfahan University of Medical Sciences, Isfahan, IR Iran

3 Al-Mahdi University, Isfahan, IR Iran

4 Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, IR Iran

5 NICU Ward, Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, IR Iran


Iranian Red Crescent Medical Journal: 16 (8); 12559
Published Online: August 4, 2014
Article Type: Research Article
Received: May 28, 2013
Accepted: February 24, 2014




Background: A few studies have been carried on preventive drugs for apnea of preterm neonates.

Objectives: This study aimed to assess the safety and prophylactic effects of aminophylline on the incidence of apnea in premature neonates.

Patients and Methods: This study was a randomized clinical trial (RCT) research. The prophylactic effect of aminophylline on apnea was investigated in premature babies in our NICU (IRAN-Isfahan). In the study group (A), 5 mg/kg aminophylline was initially administered as a loading dose. Then, every 8 hours, 1.5 mg/kg was given as maintenance dose for the next 10 days. In the control group (C), no aminophylline was used during the first ten days of life.

Results: Fifty-two neonates were randomized for the study and all of them completed it. Primary outcomes were clearly different between the two groups. Only 2 infants (7.7%) who had been placed in aminophylline group developed apnea, as compared to 16 infants (61.5%) in the control group (P < 0.001). Three and four neonates (11.5%, 15.4%) in the aminophylline group developed bradycardia and cyanosis respectively, as compared to 16 infants (61.5%) who did not receive aminophylline (P < 0.001). Median time of need to NCPAP (Nasal Continuous Positive Airway Pressure) was 1 (0 - 4) days and 2.5 (0.5 - 6.5) days in group A and C, respectively (P = 0.03). No side effects were reported in neonates (P > 0.999). Median time of hospitalization was shorter in aminophylline group (P = 0.04).

Conclusions: This study supports the preventative effects of aminophylline on apnea in extreme premature infants. In other words, the more premature an infant, the greater the preventative effect of aminophylline on the incidence of apnea and bradycardia.


Apnea of Prematurity Premature Infant Methyl xanthine Therapy Aminophylline

© 2014, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
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