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Effect of Cichorium Glandulosum Extracts on CCl4-Induced Hepatic Fibrosis

AUTHORS

Dongmei Qin 1 , * , Zhiping Wen 1 , Yaru Nie 1 , Guangmin Yao 2

AUTHORS INFORMATION

1 School of Pharmacy, Shihezi University, Shihezi, P. R. China

2 Department of Pharmacy, Tongji Medical College of Huazhong University of Science & Technology, Wuhan P. R. China

How to Cite: Qin D, Wen Z, Nie Y, Yao G. Effect of Cichorium Glandulosum Extracts on CCl4-Induced Hepatic Fibrosis, Iran Red Crescent Med J. Online ahead of Print ; 15(12):10908. doi: 10.5812/ircmj.10908.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 15 (12); 10908
Published Online: December 4, 2013
Article Type: Research Article
Received: February 21, 2013
Accepted: August 26, 2013
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Abstract

Background: Cichorium glandulosum (CG), which is a Compositae family plant, is a commonly used traditional Uighur medicine capable of cleansing liver and being cholagogue, strengthening stomach, promoting digestion, inducing diuresis and reducing edema.

Objectives: To study the liver and spleen indices, the levels of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and the histopathological changes.

Materials and Methods: Rats were intragastrically administered with the extracts of a traditional Uighur medicine Cichorium glandulosum (CG). The expressions of FN, Smard3 IGFBPrPl and TGF-?1 were detected.

Results: The liver and spleen indices of the CG-V group were significantly lower than those of the model group (p < 0.01). The hepatic fibrosis symptoms of the CG-V and CG-VII groups were significantly relieved, and more FN, Smard3 and IGFBPrPl were expressed than those in the normal group. The expressions of FN, Smard3 and TGF-?1 in all treatment groups were significantly higher than those in the normal group, and the expressions in the CG-V and CG-VII groups were significantly different from those in the model group (p < 0.05). Compared with the normal group, the apoptotic index of the model group was significantly higher, but the indices of the CG-V and CG-VII groups were significantly lower than that of the model group (p < 0.01).

Conclusions: The extracts of CG probably exerted protective effects by influencing the TGF-?/Smads signal transduction pathway.

Keywords

Chicory Liver Cirrhosis Chemokine CCL4 Blotting, Western Immunohistochemistry

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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