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Anti-Inflammatory Effect of Oleuropein in Experimental Rat Spinal Cord Trauma

AUTHORS

AR Khalatbary 1 , * , GhR Zarrinjoei 2

AUTHORS INFORMATION

1 Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Khazar Boulevard, khalat90@yahoo.com, Iran

2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad

How to Cite: Khalatbary A, Zarrinjoei G. Anti-Inflammatory Effect of Oleuropein in Experimental Rat Spinal Cord Trauma, Iran Red Crescent Med J. Online ahead of Print ; 14(4):229-234.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 14 (4); 229-234
Article Type: Research Article
Received: October 20, 2011
Accepted: January 27, 2012

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Abstract

Background: Spinal cord injury stimulates an inflammatory reaction that causes substantial secondary damage inside the injured spinal tissue. The purpose of this study was to determine the anti-inflammatory effect of oleuropein on traumatized spinal cord.

 

Methods: Rats were randomly divided into four groups of 7 rats each as follows: Sham-operated group, trauma group, and oleuropein treatment groups (20 mg/kg, ip, immediately and 1 hour after spinal cord injury). Spinal cord samples were taken 24 hours after injury and studied for immunohistochemistry of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), nitrotyrosine, inducible nitric-oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and poly(ADP-ribose) polymerase (PARP).

 

Results: Attenuated TNF-α, IL-1β, nitrotyrosine, iNOS, COX-2, and PARP expression could be detected in the oleuropein-treated rats.

 

Conclusion: Oleuropein modulates inflammatory reactions following spinal cord injury.

Keywords

Oleuropein Spinal cord Trauma Inflammation Rat

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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