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Randomized control trial: Comparison of Triple Therapy plus Probiotic Yogurt vs. Standard Triple Therapy on Helicobacter Pylori Eradication

AUTHORS

V Mirzaee 1 , * , O Rezahosseini 2

AUTHORS INFORMATION

1 Department of Gastroenterology, Rafsanjan University of Medical Sciences, vah_mirzaee@yahoo.com, Iran

2 Medical Student of Rafsanjan University of Medical Sciences, Iran

How to Cite: Mirzaee V, Rezahosseini O. Randomized control trial: Comparison of Triple Therapy plus Probiotic Yogurt vs. Standard Triple Therapy on Helicobacter Pylori Eradication, Iran Red Crescent Med J. Online ahead of Print ; 14(10):657-666.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 14 (10); 657-666
Published Online: October 30, 2012
Article Type: Research Article
Received: January 21, 2012
Accepted: September 6, 2012

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Abstract

Background: Treatment of Helicobacter pylori (H. pylori) as a major cause of gastric diseases is of utmost concern.We aimed to assess efficacy of triple therapy (amoxicillin, clarithromycin and pantoprazole) plus probiotic yogurt (PY) on eradication of H.pylori.

Methods: Total 102 H. pylori positive patients were divided to 3 groups equally and randomly. For treatment of each group Amoxicillin, clarithromycin and pantoprazole were used. Group A had additional PY, Group B ordinary low fat yogurt and Group C just had triple therapy in their regimen as well. These groups were compared regarding treatment success.

Results: Total number of 88 patients finished the treatment course. The most common experienced side effects were dysgeusia in groups A and B (25.8% and 32.3%, respectively), and dysgeusia with diarrhea and abdominal pain (30.8%) in group C. Eradication rate was, respectively, 61.3%, 64.5% and 71.3% in group A, B and C of which difference was not statistically significant (P> 0.05). However, the difference between 3 groups in regard to education level was statistically significant (P=0.005).

Conclusion: PY enriched triple therapy has decreased side effects of antibiotics consumption; however, this has no impact on eradication of Hpylori. PY and triple therapy can be used concomitantly to increase the patient tolerance.

Keywords

Helicobacter pylori probiotic yogurt triple therapy eradication

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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