IF: 0.644

Prevalence of Hepatitis B and C Infections and HCV Genotypes Among Haemophilia Patients in Ahvaz, Southwest Iran


Mohammad Ali Assarehzadegan 1 , Mehri Ghafourian Boroujerdnia 2 , * , Khodamorad Zandian 3


1 Department of Immunology,Faculty of Medicine,Ahvaz Jundishapur University of Medical Sciences, IR Iran

2 Department of Immunology,Faculty of Medicine,Thalassemia & Hemoglobinopathy Research Center,Ahvaz Jundishapur University of Medical Sciences, mehri_ghafourian@yahoo.com, IR Iran

3 Thalassemia & Hemoglobinopathy Research Center,Shafa Hospital,Ahvaz Jundishapur University of Medical Sciences Ahvaz,Ahvaz, IR Iran

How to Cite: Assarehzadegan M, Boroujerdnia M, Zandian K. Prevalence of Hepatitis B and C Infections and HCV Genotypes Among Haemophilia Patients in Ahvaz, Southwest Iran, Iran Red Crescent Med J. Online ahead of Print ; 14(8):470-474.


Iranian Red Crescent Medical Journal: 14 (8); 470-474
Article Type: Research Article
Received: July 25, 2011
Accepted: July 14, 2012




Background: Transfusion-transmitted hepatitis is the most important cause of transmitted infections by the parenteral route in patients with haemophilia.
This study was performed to determine the prevalence of HBV, HCV, and different genotypes of HCV among haemophilia patients in Ahvaz city, southwest Iran.
Patients and Methods
: A cross-sectional study was conducted on 87 haemophilia patients referred to the Hemoglobinopathy and Thalassemia research centre during February 2008 to March 2009. Patients, sera were tested for HBsAg and anti-HCV using ELISA and confirmed by PCR (HBV) and RT-PCR (HCV). HCV genotypes were determined with HCV genotype specific primers using HCV genotyping kit.
: The overall prevalence rate of HBsAg and anti-HCV were 1.1% (95% CI: 0-3.39) and 54% (95% CI: 43.5-64.4), respectively. Forty two of the anti-HCV patients (89.3%) were also HCV RNA positive. The prevalence of anti-HCV seropositivity was significantly higher (P = 0.0008) among patients who had started to receive transfusions before implementation of blood donor screening. Moreover, the number of transfusion were significantly associated with anti-HCV and HCV RNA positivity (P = 0.0041 and P = 0.023, respectively). The predominant HCV genotype among haemophilia patients in our region was 1a (26/42, 61.9%), although genotypes 1b and 3a were found in 26.1% (11/42) and 11.9% (5/42) of the patients, respectively.
: It appears stringent donor selection procedures reduced HCV infection in multi-transfused patients, but it is still serious risk for these subjects.

Please cite this paper as:
Assarehzadegan MA, Ghafourian Boroujerdnia M, Zandian Kh. Prevalence of Hepatitis B and C Infections and HCV Genotypes Among Haemophilia Patients in Ahvaz, Southwest Iran. Iran Red Crescent Med J.2012;14(8):470-4.


Hepatitis B Hepatitis C Prevalence Genotype Haemophilia A

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