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Khorasan Disease: Prevalence of HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) In West Azarbaijan from 2004 to 2007

AUTHORS

R Boostani 1 , * , A Mellat Ardakani 2 , H Ashrafi 3

1 Department of Neurology, Mashhad University of Medical Sciences, boostanir@mums.ac.ir, Khorasan, Iran

2 Department of Neurology, Mashhad University of Medical Sciences, Khorasan, Iran

3 Department of Neurology, Urmia University of Medical Sciences, West Azerbaijan, Iran

How to Cite: Boostani R, Mellat Ardakani A, Ashrafi H. Khorasan Disease: Prevalence of HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) In West Azarbaijan from 2004 to 2007, Iran Red Crescent Med J. Online ahead of Print ; 13(6):428-430.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (6); 428-430
Article Type: Brief Report
Received: October 12, 2010
Accepted: December 22, 2010

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Abstract

Background: Because of the low prevalence of ------ (HTLV-I) in comparison with Khorasan Province, considering HTLV-I as an etiology of spastic paraparesia, it may be neglected in evaluation of spastic paraparesis in the other regions of Iran.Some reports of spastic paraparetic patients due to HTLV-I infection in West Azarbaijan, caused us to reconsider the importance of HTLV-I epidemiology in the other areas of the country.

 Methods: All spastic paraparetic patients who referred to Motahari and Imam Khomeini educational hospitals of Urmia from September 2004 to September 2007 were assessed for HTLV-I infection antibodies.

Results: In our 3 years study, 11 cases were diagnosed as ----- (HAM/TSP, 2 males and 9 females).The mean age of patients at the time of diagnosis was 45.8 years. Dorsal and cervical MRI of all patients was normal. Serum Enzyme-Linked Immuno-Sorbent Assay (ELISA) and Western blot (WB) for anti HTLV-I antibody in all patients was positive. Four patients underwent for lumbar puncture in which were normal in respect of cells and biochemistry, but positive for anti-HLTLV-I antibodies.

Conclusion: HAM/TSP detection in West Azarbaijan in spite of its long distance from Khorasan Province shows the importance of anti-HTLV-I Ab assay in the blood and CSF of every spastic paraparetic patient all over the country.

Keywords

HTLV-I HAM/TSP Spastic paraparesis Iran

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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