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Intravenous Pamidronate for Refractory Lymphedema

AUTHORS

AA Beigi 1 , AM Sadeghi 2 , H Masoudpour 3 , S Shirazinejad 3 , P Mottaghi 4 , *

1 Department of Vascular Surgery, Isfahan University of Medical Sciences, Alzahra Hospital, Iran

2 Department of Surgery, Kashan University of Medical Sciences, Iran

3 Department of Surgery, Isfahan University of Medical Sciences, Alzahra Hospital, Iran

4 Associate Professor of Internal Medicine, Isfahan University of Medical Sciences, Al-Zahra Hospital, motaghi@med.mui.ac.ir, Iran

How to Cite: Beigi A, Sadeghi A, Masoudpour H, Shirazinejad S, Mottaghi P. Intravenous Pamidronate for Refractory Lymphedema, Iran Red Crescent Med J. Online ahead of Print ; 13(4):263-266.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 13 (4); 263-266
Article Type: Research Article
Received: September 12, 2010
Accepted: November 15, 2010

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Abstract

Background: Based on beneficial reports of pamidronate use for reflex sympathetic dystrophy in reduction of pain and swelling, this drug can be studied as a novel treatment for refractory lymphedema. This study aims to determine the effectiveness of pamidronate on lymphedema and its possible side effects.

Methods: Twelve cases of lower limb refractory lymphedema were enrolled. They received intravenous pamidronate monthly for 3 consecutive months and were followed by measuring any discomfort with visual analog scale (VAS) and physician global assessment, based on objective signs of limb volume and circumference.

Results: The limb volume, circumference, and satisfaction of the patients improved significantly.

Conclusion: Pamidronate when is added to conservative treatments may reduce lymphedema and improve the patient’s comfort.

Keywords

Bisphosphonate Pamidronate Refractory lymphedema

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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