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The Effect of Exam Stress on Serum IL-6, Cortisol, CRP and IgE Levels

AUTHORS

SA Shamsdin 1 , M Anvar 1 , D Mehrabani 2 , *

1 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Fars, Iran

2 Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Nemazee Hospital, mehrabad@sums.ac.ir, Fars, Iran

How to Cite: Shamsdin S, Anvar M, Mehrabani D. The Effect of Exam Stress on Serum IL-6, Cortisol, CRP and IgE Levels, Iran Red Crescent Med J. Online ahead of Print ; 12(4):484-488.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 12 (4); 484-488
Article Type: Brief Report
Received: June 12, 2009
Accepted: October 19, 2009

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Abstract

Background: Stress has determining effects on the immune response. This study was undertaken to determine the effect of exam stress on serum IL-6, cortisol, CRP and IgE levels of medical students.

 

Methods: Thirty five university medical students in Southern Iran were enrolled. Two blood samples were provided from each participant one month (first stage) and one hour (second stage) before the exam at 1.00 PM. The students completed the SpielBerger State-Trait Anxiety Inventory (STAI) questionnaire. IL-6, cortisol, CRP and IgE changes were determined in these students.

 

Results: The mean age of the students was 21 years. The exam stress resulted in a significant decrease in the IgE level and a significant increase in the cortisol level.

 

Conclusion: The exam stress can result in a decrease in the IgE level and a significant increase in the cortisol level. So, these changes may indicate the alterations of immunological status and presence of stress in an immunosuppressed individual, affecting his/her health.

Keywords

Stress Immune system IL-6 IgE CRP Cortisol

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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