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Association between PPD and QuantiFERON Gold TB Test in TB Infection and Disease among HIV-Infected Individuals in Southern Iran

AUTHORS

MA Davarpanah 1 , M Rasti 1 , Davood Mehrabani 2 , * , SS Allahyari 1 , R Neirami 1 , M Saberi-Firoozi 1

AUTHORS INFORMATION

1 Gasteroenterohepatology Research Center, Nemazee Hospital,Shiraz University of Medical Sciences, Fars, Iran

2 Assistant Professor of Pathology,Stem Cell and Transgenic Technology Research Center, and Gasteroenterohepatology Research Center, Nemazee Hospital,Shiraz University of Medical Sciences, Po Box. 71345-1744, mehrabad@sums.ac.ir, Fars, Iran

How to Cite: Davarpanah M, Rasti M, Mehrabani D, Allahyari S, Neirami R, et al. Association between PPD and QuantiFERON Gold TB Test in TB Infection and Disease among HIV-Infected Individuals in Southern Iran, Iran Red Crescent Med J. Online ahead of Print ; 11(1):71-75.

ARTICLE INFORMATION

Iranian Red Crescent Medical Journal: 11 (1); 71-75
Article Type: Research Article
Received: June 23, 2008
Accepted: November 28, 2008

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Abstract

Background: Tuberculosis is one of the most common diseases among HIV-infected patients. A person with a positive tuberculin skin test (TST) acquiring HIV infection has a 3-13% annual risk of developing active tuberculosis. The diagnosis of TB in HIV infected patients may be difficult. QuantiFERON-TB Gold (QFT-G) test is a novel method as an aid for diagnosis of Mycobacterium tuberculosis infection. We evaluated the association between TST and QFT-G test in latent TB infection (LTBI) and TB in HIV-infected patients.

 

Methods: One hundred and seventy six HIV-infected subjects from Shiraz Consultation and Behavioral Modification Center (SCBMC) entered our study. The individuals were screened for TST, using 5TU purified protein derivative (PPD). Also, blood sample was provided for QFT, measuring INF-γ response to M. tuberculosis antigen.

 

Results: Of 176 participants, 98.3% returned for evaluation of TST results. Among them, 63% and 37% were negative and positive for TST, respectively. All the participants returned for QFT-G sampling. Of them, 64.8% and 27.8% were respectively negative and positive for the test and 7.4% showed undetermined results. The agreement between PPD and QFT-G in their negative results was 39.9% and 8.1% in their positive results and the overall agreement was 50%. Disagreement of TST-/QFT+ was noticed in 19.7% of the subjects and TST+/QFT- disagreement in 24.9%. CD4+ count <100 mm3 was seen in 5.9%, ≥100 and < 200 mm3 in 17.1% and CD4+ T cell count ³ 200 mm3 in 76.9% of subjects.

 

Conclusion: As the agreement rate between QFT-G and TST in HIV-infected patients was fair, a strategy of simultaneous TST and QFT-G testing would maximize the potential for LTBI diagnosis in HIV-infected subjects.

 

Keywords

HIV Tuberculosis QuantiFERON Gold TB test PPD

© 0, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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