Iranian Red Crescent Medical Journal

Published by: Kowsar

Toxoplasma gondii: The Prevalence and Risk Factors in HIV-Infected Patients in Fars Province, Southern Iran

Nasir Arefkhah 1 , Bahador Sarkari 1 , 2 , * , Masood Afrashteh 1 , Zahra Rezaei 3 and Mona Dehghani 1
Authors Information
1 Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
2 Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Article information
  • Iranian Red Crescent Medical Journal: June 2018, 20 (6); e66521
  • Published Online: September 3, 2018
  • Article Type: Research Article
  • Received: January 20, 2018
  • Revised: March 11, 2018
  • Accepted: April 27, 2018
  • DOI: 10.5812/ircmj.66521

To Cite: Arefkhah N, Sarkari B, Afrashteh M, Rezaei Z, Dehghani M. Toxoplasma gondii: The Prevalence and Risk Factors in HIV-Infected Patients in Fars Province, Southern Iran, Iran Red Crescent Med J. 2018 ; 20(6):e66521. doi: 10.5812/ircmj.66521.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Ahmadpour E, Daryani A, Sharif M, Sarvi S, Aarabi M, Mizani A, et al. Toxoplasmosis in immunocompromised patients in Iran: A systematic review and meta-analysis. J Infect Dev Ctries. 2014;8(12):1503-10. doi: 10.3855/jidc.4796. [PubMed: 25500647].
  • 2. Pereira-Chioccola VL, Vidal JE, Su C. Toxoplasma gondii infection and cerebral toxoplasmosis in HIV-infected patients. Future Microbiol. 2009;4(10):1363-79. doi: 10.2217/fmb.09.89. [PubMed: 19995194].
  • 3. Sarkari B, Abdolahi Khabisi S. Severe congenital toxoplasmosis: A case report and strain characterization. Case Rep Infect Dis. 2015;2015:851085. doi: 10.1155/2015/851085. [PubMed: 25685568]. [PubMed Central: PMC4313519].
  • 4. Asgari Q, Fekri M, Monabati A, Kalantary M, Mohammadpour I, Motazedian MH, et al. Molecular genotyping of Toxoplasma gondii in human spontaneous aborted fetuses in Shiraz, southern Iran. Iran J Public Health. 2013;42(6):620-5. [PubMed: 23967430]. [PubMed Central: PMC3744259].
  • 5. Wang ZD, Wang SC, Liu HH, Ma HY, Li ZY, Wei F, et al. Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: A systematic review and meta-analysis. Lancet HIV. 2017;4(4):e177-88. doi: 10.1016/S2352-3018(17)30005-X. [PubMed: 28159548].
  • 6. Addebbous A, Adarmouch L, Tali A, Laboudi M, Amine M, Aajly L, et al. IgG anti-Toxoplasma antibodies among asymptomatic HIV-infected patients in Marrakesh-Morocco. Acta Trop. 2012;123(1):49-52. doi: 10.1016/j.actatropica.2012.02.070. [PubMed: 22425678].
  • 7. Xavier GA, Cademartori BG, Cunha Filho NA, Farias NA. Evaluation of seroepidemiological toxoplasmosis in HIV/AIDS patients in the south of Brazil. Rev Inst Med Trop Sao Paulo. 2013;55(1):25-30. [PubMed: 23328722].
  • 8. Abdoli A. Neglected risk factors for HIV and Toxoplasma gondii co-infection. Lancet HIV. 2017;4(4). e152. doi: 10.1016/S2352-3018(17)30048-6. [PubMed: 28359447].
  • 9. Bagheri Amiri F, Mostafavi E, Mirzazadeh A. HIV, HBV and HCV coinfection prevalence in Iran: A systematic review and meta-analysis. PLoS One. 2016;11(3). e0151946. doi: 10.1371/journal.pone.0151946. [PubMed: 27031352]. [PubMed Central: PMC4816272].
  • 10. Barazesh A, Sarkari B, Mehrabi Sisakht F, Abdolahi Khabisi S, Nikbakht R, Ravanbod MR. Seroprevalence and molecular evaluation of toxoplasmosis in patients undergoing chemotherapy for malignancies in the Bushehr province, southwest Iran. Jundishapur J Microbiol. 2016;9(9). e35410. doi: 10.5812/jjm.35410. [PubMed: 27800144]. [PubMed Central: PMC5086028].
  • 11. Daryani A, Sarvi S, Aarabi M, Mizani A, Ahmadpour E, Shokri A, et al. Seroprevalence of Toxoplasma gondii in the Iranian general population: A systematic review and meta-analysis. Acta Trop. 2014;137:185-94. doi: 10.1016/j.actatropica.2014.05.015. [PubMed: 24887263].
  • 12. Ilami O, Sarkari B, Khosravani A, Tori MA, Hosseini Z. HIV seroprevalence among high-risk groups in Kohgiloyeh and Boyerahmad province, southwest of Iran, a behavioral surveillance survey. AIDS Behav. 2012;16(1):86-90. doi: 10.1007/s10461-010-9874-x. [PubMed: 21190072].
  • 13. Sarkari B, Shafiei R, Zare M, Sohrabpour S, Kasraian L. Seroprevalence and molecular diagnosis of Toxoplasma gondii infection among blood donors in southern Iran. J Infect Dev Ctries. 2014;8(4):543-7. doi: 10.3855/jidc.3831. [PubMed: 24727522].
  • 14. Rezanezhad H, Sayadi F, Shadmand E, Nasab SD, Yazdi HR, Solhjoo K, et al. Seroprevalence of Toxoplasma gondii among HIV patients in Jahrom, southern Iran. Korean J Parasitol. 2017;55(1):99-103. doi: 10.3347/kjp.2017.55.1.99. [PubMed: 28285515]. [PubMed Central: PMC5365268].
  • 15. Mohraz M, Mehrkhani F, Jam S, SeyedAlinaghi S, Sabzvari D, Fattahi F, et al. Seroprevalence of toxoplasmosis in HIV(+)/AIDS patients in Iran. Acta Med Iran. 2011;49(4):213-8. [PubMed: 21713730].
  • 16. Rahimi MT, Mahdavi SA, Javadian B, Rezaei R, Moosazadeh M, Khademlou M, et al. High seroprevalence of Toxoplasma gondii antibody in HIV/AIDS individuals from north of Iran. Iran J Parasitol. 2015;10(4):584-9. [PubMed: 26811725]. [PubMed Central: PMC4724835].
  • 17. Rostami A, Keshavarz H, Shojaee S, Mohebali M, Meamar AR. Frequency of Toxoplasma gondii in HIV positive patients from west of Iran by ELISA and PCR. Iran J Parasitol. 2014;9(4):474-81. [PubMed: 25759728]. [PubMed Central: PMC4345086].
  • 18. Davarpanah MA, Mehrabani D, Neirami R, Ghahremanpoori M, Darvishi M. Toxoplasmosis in HIV/AIDS patients in Shiraz, southern Iran. Iran Red Crescent Med J. 2007;9(9):22-7.
  • 19. Asgari Q, Sarnevesht J, Kalantari M, Sadat SJ, Motazedian MH, Sarkari B. Molecular survey of Toxoplasma infection in sheep and goat from Fars province, southern Iran. Trop Anim Health Prod. 2011;43(2):389-92. doi: 10.1007/s11250-010-9704-1. [PubMed: 20936348].
  • 20. Sarkari B, Ahmadpour NB, Motazedian MH, Mirjalali H, Akhoundi M, Mohebali M, et al. Inter- and Intraspecific variations of Leishmania strains isolated from patients with cutaneous and visceral leishmaniases in Fars province, south of Iran. Iran J Med Sci. 2016;41(3):209-16. [PubMed: 27217605]. [PubMed Central: PMC4876299].
  • 21. Sarkari B, Gadami F, Shafiei R, Motazedian MH, Sedaghat F, Kasraian L, et al. Seroprevalence of Leishmania infection among the healthy blood donors in kala-azar endemic areas of Iran. J Parasit Dis. 2015;39(3):545-9. doi: 10.1007/s12639-013-0393-3. [PubMed: 26345068]. [PubMed Central: PMC4554570].
  • 22. Sarkari B, Hatam G, Ghatee M. Epidemiological features of visceral leishmaniasis in Fars province, southern Iran. Iran J Public Health. 2012;41(4):94-9. [PubMed: 23113170]. [PubMed Central: PMC3481615].
  • 23. Sarkari B, Hatam GR, Adnani SJ, Asgari Q. Seroprevalence of feline leishmaniasis in areas of Iran where Leishmania infantum is endemic. Ann Trop Med Parasitol. 2009;103(3):275-7. doi: 10.1179/136485909X398276. [PubMed: 19341541].
  • 24. Sarkari B, Naraki T, Ghatee MA, Abdolahi Khabisi S, Davami MH. Visceral leishmaniasis in southwestern Iran: A retrospective clinico-hematological analysis of 380 consecutive hospitalized cases (1999 - 2014). PLoS One. 2016;11(3). e0150406. doi: 10.1371/journal.pone.0150406. [PubMed: 26942443]. [PubMed Central: PMC4778872].
  • 25. Sarkari B, Ashrafmansori A, Hatam GR, Motazedian MH, Asgari Q, Mohammadpour I. Genotyping of Giardia lamblia isolates from human in southern Iran. Trop Biomed. 2012;29(3):366-71. [PubMed: 23018499].
  • 26. Ajzenberg D, Lamaury I, Demar M, Vautrin C, Cabie A, Simon S, et al. Performance testing of PCR assay in blood samples for the diagnosis of toxoplasmic encephalitis in AIDS patients from the French Departments of America and Genetic Diversity of Toxoplasma gondii: A prospective and multicentric study. PLoS Negl Trop Dis. 2016;10(6). e0004790. doi: 10.1371/journal.pntd.0004790. [PubMed: 27355620]. [PubMed Central: PMC4927177].
  • 27. Shafiei R, Riazi Z, Sarvghad M, Galian Sharifdini M, Mahmoodzadeh A, Hajia M. Prevalence of IgG and IgM anti-Toxoplasma gondii antibodies in HIV positive patients in northeast of Iran. Iran J Pathol. 2011;6(2):68-72.
  • 28. Shimelis T, Tebeje M, Tadesse E, Tegbaru B, Terefe A. Sero-prevalence of latent Toxoplasma gondii infection among HIV-infected and HIV-uninfected people in Addis Ababa, Ethiopia: A comparative cross-sectional study. BMC Res Notes. 2009;2:213. doi: 10.1186/1756-0500-2-213. [PubMed: 19852805]. [PubMed Central: PMC2770475].
  • 29. Pappoe F, Cheng W, Wang L, Li Y, Obiri-Yeboah D, Nuvor SV, et al. Prevalence of Toxoplasma gondii infection in HIV-infected patients and food animals and direct genotyping of T. gondii isolates, southern Ghana. Parasitol Res. 2017;116(6):1675-85. doi: 10.1007/s00436-017-5442-x. [PubMed: 28434050].
  • 30. Chemoh W, Sawangjaroen N, Siripaitoon P, Andiappan H, Hortiwakul T, Sermwittayawong N, et al. Toxoplasma gondii – prevalence and risk factors in HIV-infected patients from Songklanagarind Hospital, southern Thailand. Frontiers Microbiol. 2015;6. doi: 10.3389/fmicb.2015.01304.
  • 31. Ganiem AR, Dian S, Indriati A, Chaidir L, Wisaksana R, Sturm P, et al. Cerebral toxoplasmosis mimicking subacute meningitis in HIV-infected patients; a cohort study from Indonesia. PLoS Negl Trop Dis. 2013;7(1). e1994. doi: 10.1371/journal.pntd.0001994. [PubMed: 23326616]. [PubMed Central: PMC3542116].
  • 32. Sarkari B, Asgari Q, Bagherian N, Ashkani Esfahani S, Kalantari M, Mohammadpour I, et al. Molecular and serological evaluation of Toxoplasma gondii infection in reared Turkeys in Fars province, Iran. Jundishapur J Microbiol. 2014;7(7). e11598. doi: 10.5812/jjm.11598. [PubMed: 25368800]. [PubMed Central: PMC4216580].
  • 33. Sarkari B, Taghizadeh H, Shahriarirad R, Erfani A, Nekouei F, Seifbehzad S, et al. Seroepidemiological survey of toxoplasmosis among female university students in Shiraz, southern Iran. Ann Trop Med Public Health. 2017;10(2):362. doi: 10.4103/1755-6783.208724.
  • 34. Ghosn J, Paris L, Ajzenberg D, Carcelain G, Darde ML, Tubiana R, et al. Atypical toxoplasmic manifestation after discontinuation of maintenance therapy in a human immunodeficiency virus type 1-infected patient with immune recovery. Clin Infect Dis. 2003;37(7):e112-4. doi: 10.1086/378126. [PubMed: 13130422].

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