Iranian Red Crescent Medical Journal

Published by: Kowsar

Expression of Long Non-Coding RNAs (UCA1 and CCAT2) in the Blood of Multiple Sclerosis Patients: A Case - Control Study

Romina Dastmalchi 1 , Mir Davood Omrani 1 , 2 , Mehrdokht Mazdeh 3 , 4 , Shahram Arsang-Jang 5 , Abolfazl Movafagh 1 , Arezou Sayad 1 , * and Mohammad Taheri 1 , 2 , **
Authors Information
1 Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Biostatistics and Epidemiology, Qom University of Medical Sciences, Qom, Iran
4 Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
5 Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran
Corresponding Authors:
Article information
  • Iranian Red Crescent Medical Journal: August 2018, 20 (8); e66334
  • Published Online: September 17, 2018
  • Article Type: Research Article
  • Received: January 15, 2018
  • Revised: February 26, 2018
  • Accepted: March 29, 2018
  • DOI: 10.5812/ircmj.66334

To Cite: Dastmalchi R, Omrani M D , Mazdeh M, Arsang-Jang S, Movafagh A, et al. Expression of Long Non-Coding RNAs (UCA1 and CCAT2) in the Blood of Multiple Sclerosis Patients: A Case - Control Study, Iran Red Crescent Med J. 2018 ; 20(8):e66334. doi: 10.5812/ircmj.66334.

Abstract
Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Goldenberg MM. Multiple sclerosis review. Pharm Therapeutic. 2012;37(3):175-84. [PubMed: 22605909]. [PubMed Central: PMC3351877].
  • 2. McFarland HF, Martin R. Multiple sclerosis: A complicated picture of autoimmunity. Nat Immunol. 2007;8(9):913-9. doi: 10.1038/ni1507. [PubMed: 17712344].
  • 3. Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol. 2000;47(6):707-17. doi: 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q. [PubMed: 10852536].
  • 4. Eftekharian MM, Ghafouri-Fard S, Soudyab M, Omrani MD, Rahimi M, Sayad A, et al. Expression analysis of long non-coding RNAs in the blood of multiple sclerosis patients. J Mol Neurosci. 2017;63(3-4):333-41. doi: 10.1007/s12031-017-0982-1. [PubMed: 28967047].
  • 5. Santoro M, Nociti V, Lucchini M, De Fino C, Losavio FA, Mirabella M. Expression profile of long non-coding RNAs in serum of patients with multiple sclerosis. J Mol Neurosci. 2016;59(1):18-23. doi: 10.1007/s12031-016-0741-8. [PubMed: 27034068].
  • 6. Li X, Wu Z, Fu X, Han W. Long noncoding RNAs: Insights from biological features and functions to diseases. Med Res Rev. 2013;33(3):517-53. doi: 10.1002/med.21254. [PubMed: 22318902].
  • 7. Rinn JL, Chang HY. Genome regulation by long noncoding RNAs. Annu Rev Biochem. 2012;81:145-66. doi: 10.1146/annurev-biochem-051410-092902. [PubMed: 22663078]. [PubMed Central: PMC3858397].
  • 8. Sigdel KR, Cheng A, Wang Y, Duan L, Zhang Y. The emerging functions of long noncoding RNA in immune cells: autoimmune diseases. J Immunol Res. 2015;2015:848790. doi: 10.1155/2015/848790. [PubMed: 26090502]. [PubMed Central: PMC4451983].
  • 9. Pender MP. Genetically determined failure of activation-induced apoptosis of autoreactive T cells as a cause of multiple sclerosis. Lancet. 1998;351(9107):978-81. doi: 10.1016/S0140-6736(05)60642-3. [PubMed: 9734959].
  • 10. Satoh J, Nakanishi M, Koike F, Miyake S, Yamamoto T, Kawai M, et al. Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis. Neurobiol Dis. 2005;18(3):537-50. doi: 10.1016/j.nbd.2004.10.007. [PubMed: 15755681].
  • 11. Hu X, Teng X, Zheng H, Shan Z, Li J, Jin T, et al. Iron deficiency without anemia causes maternal hypothyroxinemia in pregnant rats. Nutr Res. 2014;34(7):604-12. doi: 10.1016/j.nutres.2014.06.007. [PubMed: 25150119].
  • 12. Tehrani SS, Karimian A, Parsian H, Majidinia M, Yousefi B. Multiple functions of long non-coding RNAs in oxidative stress, DNA damage response and cancer progression. J Cell Biochem. 2018;119(1):223-36. doi: 10.1002/jcb.26217. [PubMed: 28608608].
  • 13. Han Y, Yang YN, Yuan HH, Zhang TT, Sui H, Wei XL, et al. UCA1, a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation, apoptosis and cell cycle distribution. Pathology. 2014;46(5):396-401. doi: 10.1097/PAT.0000000000000125. [PubMed: 24977734].
  • 14. Xue Y, Teng YQ, Zhou JD, Rui YJ. Long noncoding RNA CCAT2 as an independent prognostic marker in various carcinomas: evidence based on four studies. Int J Clin Exp Med. 2016;9(2):2567-72.
  • 15. Zhou N, Si Z, Li T, Chen G, Zhang Z, Qi H. Long non-coding RNA CCAT2 functions as an oncogene in hepatocellular carcinoma, regulating cellular proliferation, migration and apoptosis. Oncol Lett. 2016;12(1):132-8. doi: 10.3892/ol.2016.4580. [PubMed: 27347113]. [PubMed Central: PMC4906942].
  • 16. Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011;69(2):292-302. doi: 10.1002/ana.22366. [PubMed: 21387374]. [PubMed Central: PMC3084507].
  • 17. Mazdeh M, Taheri M, Sayad A, Bahram S, Omrani MD, Movafagh A, et al. HLA genes as modifiers of response to IFN-beta-1a therapy in relapsing-remitting multiple sclerosis. Pharmacogenomics. 2016;17(5):489-98. doi: 10.2217/pgs.16.2. [PubMed: 27020477].
  • 18. Taheri M, Ghafouri-Fard S, Solgi G, Sayad A, Mazdeh M, Omrani MD. Determination of cytokine levels in multiple sclerosis patients and their relevance with patients' response to cinnovex. Cytokine. 2017;96:138-43. doi: 10.1016/j.cyto.2017.04.007. [PubMed: 28399486].
  • 19. Sayad A, Ghafouri-Fard S, Omrani MD, Noroozi R, Taheri M. Myxovirus resistance protein A (MxA) polymorphism is associated with IFNbeta response in Iranian multiple sclerosis patients. Neurol Sci. 2017;38(6):1093-9. doi: 10.1007/s10072-017-2935-4. [PubMed: 28386647].
  • 20. Roxburgh RH, Seaman SR, Masterman T, Hensiek AE, Sawcer SJ, Vukusic S, et al. Multiple sclerosis severity score: Using disability and disease duration to rate disease severity. Neurology. 2005;64(7):1144-51. doi: 10.1212/01.WNL.0000156155.19270.F8. [PubMed: 15824338].
  • 21. Tuo YL, Li XM, Luo J. Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143. Eur Rev Med Pharmacol Sci. 2015;19(18):3403-11. [PubMed: 26439035].
  • 22. Wang F, Li X, Xie X, Zhao L, Chen W. UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion. FEBS Lett. 2008;582(13):1919-27. doi: 10.1016/j.febslet.2008.05.012. [PubMed: 18501714].
  • 23. Huang S, Qing C, Huang Z, Zhu Y. The long non-coding RNA CCAT2 is up-regulated in ovarian cancer and associated with poor prognosis. Diagn Pathol. 2016;11(1):49. doi: 10.1186/s13000-016-0499-x. [PubMed: 27283598]. [PubMed Central: PMC4901397].
  • 24. Qiu M, Xu Y, Yang X, Wang J, Hu J, Xu L, et al. CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer. Tumour Biol. 2014;35(6):5375-80. doi: 10.1007/s13277-014-1700-z. [PubMed: 24504682].
  • 25. Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, et al. CCAT2, a novel long non-coding RNA in breast cancer: Expression study and clinical correlations. Oncotarget. 2013;4(10):1748-62. doi: 10.18632/oncotarget.1292. [PubMed: 24077681]. [PubMed Central: PMC3858561].
  • 26. Xie P, Cao H, Li Y, Wang J, Cui Z. Knockdown of lncRNA CCAT2 inhibits endometrial cancer cells growth and metastasis via sponging miR-216b. Cancer Biomark. 2017;21(1):123-33. doi: 10.3233/CBM-170388. [PubMed: 29036788].
  • 27. Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p. Sci Rep. 2016;6:23892. doi: 10.1038/srep23892. [PubMed: 27046651]. [PubMed Central: PMC4820696].
  • 28. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, et al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013;23(9):1446-61. doi: 10.1101/gr.152942.112. [PubMed: 23796952]. [PubMed Central: PMC3759721].
  • 29. Zhang X, Xu Y, He C, Guo X, Zhang J, He C, et al. Elevated expression of CCAT2 is associated with poor prognosis in esophageal squamous cell carcinoma. J Surg Oncol. 2015;111(7):834-9. doi: 10.1002/jso.23888. [PubMed: 25919911].
  • 30. Li JY, Ma X, Zhang CB. Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7(11):7938-44. [PubMed: 25550835]. [PubMed Central: PMC4270573].
  • 31. Ong MS, Cai W, Yuan Y, Leong HC, Tan TZ, Mohammad A, et al. 'Lnc'-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling. Br J Pharmacol. 2017;174(24):4684-700. doi: 10.1111/bph.13958. [PubMed: 28736855]. [PubMed Central: PMC5727316].
  • 32. Yuan S, Shi Y, Tang SJ. Wnt signaling in the pathogenesis of multiple sclerosis-associated chronic pain. J Neuroimmune Pharmacol. 2012;7(4):904-13. doi: 10.1007/s11481-012-9370-3. [PubMed: 22547300].
  • 33. Devier DJ, Lovera JF, Lukiw WJ. Increase in NF-kappaB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration. Front Mol Neurosci. 2015;8:5. doi: 10.3389/fnmol.2015.00005. [PubMed: 25784854]. [PubMed Central: PMC4345893].
  • 34. Wang HK, Yan H, Wang K, Wang J. Dynamic regulation effect of long non-coding RNA-UCA1 on NF-kB in hippocampus of epilepsy rats. Eur Rev Med Pharmacol Sci. 2017;21(13):3113-9. [PubMed: 28742194].
  • 35. Yang C, Li X, Wang Y, Zhao L, Chen W. Long non-coding RNA UCA1 regulated cell cycle distribution via CREB through PI3-K dependent pathway in bladder carcinoma cells. Gene. 2012;496(1):8-16. doi: 10.1016/j.gene.2012.01.012. [PubMed: 22285928].
  • 36. Wang F, Ying HQ, He BS, Pan YQ, Deng QW, Sun HL, et al. Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway. Oncotarget. 2015;6(10):7899-917. doi: 10.18632/oncotarget.3219. [PubMed: 25760077]. [PubMed Central: PMC4480724].
  • 37. Huang J, Zhou N, Watabe K, Lu Z, Wu F, Xu M, et al. Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 2014;5. e1008. doi: 10.1038/cddis.2013.541. [PubMed: 24457952]. [PubMed Central: PMC4040676].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments