Iranian Red Crescent Medical Journal

Published by: Kowsar

Dietary and Serum Level of Antioxidants in the Elderly with Mild Impaired and Normal Cognitive Function: A Case-Control Study

Hormoz Ayromlou 1 , Parisa Pourvahed 2 , Fatemeh Jahanjoo 3 , Homayoun Dolatkhah 4 , Seyyed Kazem Shakouri 3 and Neda Dolatkhah 3 , *
Authors Information
1 Department of Neurology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 Tabriz University of Medical Sciences, Tabriz, Iran
3 Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Article information
  • Iranian Red Crescent Medical Journal: November 2018, 20 (11); e64847
  • Published Online: October 31, 2018
  • Article Type: Research Article
  • Received: December 7, 2017
  • Revised: January 22, 2018
  • Accepted: February 24, 2018
  • DOI: 10.5812/ircmj.64847

To Cite: Ayromlou H, Pourvahed P, Jahanjoo F, Dolatkhah H, Shakouri S K, et al. Dietary and Serum Level of Antioxidants in the Elderly with Mild Impaired and Normal Cognitive Function: A Case-Control Study, Iran Red Crescent Med J. 2018 ; 20(11):e64847. doi: 10.5812/ircmj.64847.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Kokmen E, Tangelos EG. Aging, memory, and mild cognitive impairment. Int Psychogeriatr. 1997;9 Suppl 1:65-9. [PubMed: 9447429].
  • 2. Sachdev PS, Blacker D, Blazer DG, Ganguli M, Jeste DV, Paulsen JS, et al. Classifying neurocognitive disorders: The DSM-5 approach. Nat Rev Neurol. 2014;10(11):634-42. doi: 10.1038/nrneurol.2014.181. [PubMed: 25266297].
  • 3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-5®). 5th ed. American Psychiatric Publishing; 2013.
  • 4. Sanford AM. Mild cognitive impairment. Clin Geriatr Med. 2017;33(3):325-37. doi: 10.1016/j.cger.2017.02.005. [PubMed: 28689566].
  • 5. Noorbakhsh F, Overall CM, Power C. Deciphering complex mechanisms in neurodegenerative diseases: The advent of systems biology. Trends Neurosci. 2009;32(2):88-100. doi: 10.1016/j.tins.2008.10.003. [PubMed: 19135729].
  • 6. Busse A, Hensel A, Guhne U, Angermeyer MC, Riedel-Heller SG. Mild cognitive impairment: Long-term course of four clinical subtypes. Neurology. 2006;67(12):2176-85. doi: 10.1212/01.wnl.0000249117.23318.e1. [PubMed: 17190940].
  • 7. Di Carlo A, Lamassa M, Baldereschi M, Inzitari M, Scafato E, Farchi G, et al. CIND and MCI in the Italian elderly: Frequency, vascular risk factors, progression to dementia. Neurology. 2007;68(22):1909-16. doi: 10.1212/01.wnl.0000263132.99055.0d. [PubMed: 17536047].
  • 8. Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, et al. Prevalence of cognitive impairment without dementia in the United States. Ann Intern Med. 2008;148(6):427-34. [PubMed: 18347351]. [PubMed Central: PMC2670458].
  • 9. Manly JJ, Tang MX, Schupf N, Stern Y, Vonsattel JP, Mayeux R. Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol. 2008;63(4):494-506. doi: 10.1002/ana.21326. [PubMed: 18300306]. [PubMed Central: PMC2375143].
  • 10. Lopez OL, Jagust WJ, DeKosky ST, Becker JT, Fitzpatrick A, Dulberg C, et al. Prevalence and classification of mild cognitive impairment in the cardiovascular health study cognition study: Part 1. Arch Neurol. 2003;60(10):1385-9. doi: 10.1001/archneur.60.10.1385. [PubMed: 14568808].
  • 11. Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, et al. Mild cognitive impairment. Lancet. 2006;367(9518):1262-70. doi: 10.1016/S0140-6736(06)68542-5. [PubMed: 16631882].
  • 12. Petersen RC. Clinical practice. Mild cognitive impairment. N Engl J Med. 2011;364(23):2227-34. doi: 10.1056/NEJMcp0910237. [PubMed: 21651394].
  • 13. Balmus IM, Strungaru SA, Ciobica A, Nicoara MN, Dobrin R, Plavan G, et al. Preliminary data on the interaction between some biometals and oxidative stress status in mild cognitive impairment and Alzheimer's disease patients. Oxid Med Cell Longev. 2017;2017:7156928. doi: 10.1155/2017/7156928. [PubMed: 28811866]. [PubMed Central: PMC5546061].
  • 14. Raza H, John A. Streptozotocin-induced cytotoxicity, oxidative stress and mitochondrial dysfunction in human hepatoma HepG2 cells. Int J Mol Sci. 2012;13(5):5751-67. doi: 10.3390/ijms13055751. [PubMed: 22754329]. [PubMed Central: PMC3382802].
  • 15. Samuel S, Kathirvel R, Jayavelu T, Chinnakkannu P. Protein oxidative damage in arsenic induced rat brain: Influence of DL-alpha-lipoic acid. Toxicol Lett. 2005;155(1):27-34. doi: 10.1016/j.toxlet.2004.08.001. [PubMed: 15585356].
  • 16. Travica N, Ried K, Sali A, Scholey A, Hudson I, Pipingas A. Vitamin C status and cognitive function: A systematic review. Nutrients. 2017;9(9). doi: 10.3390/nu9090960. [PubMed: 28867798]. [PubMed Central: PMC5622720].
  • 17. Crichton GE, Bryan J, Murphy KJ. Dietary antioxidants, cognitive function and dementia: A systematic review. Plant Foods Hum Nutr. 2013;68(3):279-92. doi: 10.1007/s11130-013-0370-0. [PubMed: 23881465].
  • 18. Vauzour D. Effect of flavonoids on learning, memory and neurocognitive performance: Relevance and potential implications for Alzheimer's disease pathophysiology. J Sci Food Agric. 2014;94(6):1042-56. doi: 10.1002/jsfa.6473. [PubMed: 24338740].
  • 19. Spencer JP. The impact of fruit flavonoids on memory and cognition. Br J Nutr. 2010;104 Suppl 3:S40-7. doi: 10.1017/S0007114510003934. [PubMed: 20955649].
  • 20. Solfrizzi V, Panza F, Frisardi V, Seripa D, Logroscino G, Imbimbo BP, et al. Diet and Alzheimer's disease risk factors or prevention: The current evidence. Expert Rev Neurother. 2011;11(5):677-708. doi: 10.1586/ern.11.56. [PubMed: 21539488].
  • 21. Cheung BH, Ho IC, Chan RS, Sea MM, Woo J. Current evidence on dietary pattern and cognitive function. Adv Food Nutr Res. 2014;71:137-63. doi: 10.1016/B978-0-12-800270-4.00004-3. [PubMed: 24484941].
  • 22. Tangney CC, Kwasny MJ, Li H, Wilson RS, Evans DA, Morris MC. Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr. 2011;93(3):601-7. doi: 10.3945/ajcn.110.007369. [PubMed: 21177796]. [PubMed Central: PMC3041601].
  • 23. Zhao X, Yuan L, Feng L, Xi Y, Yu H, Ma W, et al. Association of dietary intake and lifestyle pattern with mild cognitive impairment in the elderly. J Nutr Health Aging. 2015;19(2):164-8. doi: 10.1007/s12603-014-0524-2. [PubMed: 25651441].
  • 24. Lloret A, Badia MC, Mora NJ, Pallardo FV, Alonso MD, Vina J. Vitamin E paradox in Alzheimer's disease: It does not prevent loss of cognition and may even be detrimental. J Alzheimers Dis. 2009;17(1):143-9. doi: 10.3233/JAD-2009-1033. [PubMed: 19494439].
  • 25. Riviere S, Birlouez-Aragon I, Nourhashemi F, Vellas B. Low plasma vitamin C in Alzheimer patients despite an adequate diet. Int J Geriatr Psychiatry. 1998;13(11):749-54. [PubMed: 9850871].
  • 26. Pearson JF, Pullar JM, Wilson R, Spittlehouse JK, Vissers MCM, Skidmore PML, et al. Vitamin C status correlates with markers of metabolic and cognitive health in 50-year-olds: Findings of the CHALICE cohort study. Nutrients. 2017;9(8). doi: 10.3390/nu9080831. [PubMed: 28771190]. [PubMed Central: PMC5579624].
  • 27. Ide K, Yamada H, Kawasaki Y, Yamanaka M, Kawakami N, Katsuyama Y, et al. Peripheral vitamin C levels in Alzheimer's disease: A cross-sectional study. J Nutr Sci Vitaminol (Tokyo). 2016;62(6):432-6. doi: 10.3177/jnsv.62.432. [PubMed: 28202849].
  • 28. Devore EE, Kang JH, Stampfer MJ, Grodstein F. The association of antioxidants and cognition in the nurses' health study. Am J Epidemiol. 2013;177(1):33-41. doi: 10.1093/aje/kws202. [PubMed: 23221724]. [PubMed Central: PMC3590037].
  • 29. Johnson EJ, Vishwanathan R, Johnson MA, Hausman DB, Davey A, Scott TM, et al. Relationship between serum and brain carotenoids, alpha-tocopherol, and retinol concentrations and cognitive performance in the oldest old from the georgia centenarian study. J Aging Res. 2013;2013:951786. doi: 10.1155/2013/951786. [PubMed: 23840953]. [PubMed Central: PMC3690640].
  • 30. Jimenez-Jimenez FJ, Molina JA, de Bustos F, Orti-Pareja M, Benito-Leon J, Tallon-Barranco A, et al. Serum levels of beta-carotene, alpha-carotene and vitamin A in patients with Alzheimer's disease. Eur J Neurol. 1999;6(4):495-7. [PubMed: 10362906].
  • 31. Kalmijn S, Feskens EJ, Launer LJ, Kromhout D. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol. 1997;145(1):33-41. [PubMed: 8982020].
  • 32. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183-94. doi: 10.1111/j.1365-2796.2004.01388.x. [PubMed: 15324362].
  • 33. Cahill LE, El-Sohemy A. Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid. J Nutrigenet Nutrigenomics. 2009;2(6):292-301. doi: 10.1159/000314597. [PubMed: 20588054].
  • 34. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test – second edition. Adult version. Manual. San Antonio, TX: Psychological Corporation; 2000.
  • 35. Wechsler D. Wechsler adult intelligence scale-III. San Antonio, TX: Psychological Corporation; 1997.
  • 36. Spreen O, Strauss E. A compendium of neuropsychological tests: Administration, norms and commentary. New York, NY: Oxford University Press; 1991.
  • 37. Folstein MF, Folstein SE, McHugh PR. ["Mini-mental state". A practical method for grading the cognitive state of patients for the clinician]. J Psychiatr Res. 1975;12(3):189-98. Persian.
  • 38. Malakouti K, Fathollahi P, Mirabzadeh A, Salavati M, Kahani SH. [Validation of geriatric depression scale (GDS-15) in Iran]. Res Med. 2006;30(4):361-9. Persian.
  • 39. Mirmiran P, Esfahani FH, Mehrabi Y, Hedayati M, Azizi F. Reliability and relative validity of an FFQ for nutrients in the Tehran lipid and glucose study. Public Health Nutr. 2010;13(5):654-62. doi: 10.1017/S1368980009991698. [PubMed: 19807937].
  • 40. Jalilpiran Y, Hezaveh E, Bahmanpour S, Faghih S. Healthy plant foods intake could protect against prostate cancer risk: A case-control study. Asian Pac J Cancer Prev. 2017;18(7):1905-12. doi: 10.22034/APJCP.2017.18.7.1905. [PubMed: 28749619]. [PubMed Central: PMC5648397].
  • 41. Hilasaca-Mamani M, Barbosa Tde S, Fegadolli C, Castelo PM. Validity and reliability of the quality of masticatory function questionnaire applied in Brazilian adolescents. Codas. 2016;28(2):149-54. doi: 10.1590/2317-1782/20162015070. [PubMed: 27191878].
  • 42. Michels AJ, Frei B. Myths, artifacts, and fatal flaws: Identifying limitations and opportunities in vitamin C research. Nutrients. 2013;5(12):5161-92. doi: 10.3390/nu5125161. [PubMed: 24352093]. [PubMed Central: PMC3875932].
  • 43. Gowenlock AH. Varley's practical clinical biochemistry. 6th ed. London, UK: Heinemann Medical Books; 1988.
  • 44. Kaplan LA, Miller JA, Stein EA. Simultaneous measurement of serum retinol, tocopherols, carotenes, and carotenoids by high performance liquid chromatography. J Clin Lab Anal. 1987;1(2):147-52. doi: 10.1002/jcla.1860010202.
  • 45. Mahan LK, Escott-Stump S, Raymond JL, Krause MV. Krause's food and the nutrition care process. 13th ed. Elsevier/Saunders; 2012.
  • 46. Rinaldi P, Polidori MC, Metastasio A, Mariani E, Mattioli P, Cherubini A, et al. Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging. 2003;24(7):915-9. [PubMed: 12928050].
  • 47. Zhao LG, Shu XO, Li HL, Zhang W, Gao J, Sun JW, et al. Dietary antioxidant vitamins intake and mortality: A report from two cohort studies of Chinese adults in Shanghai. J Epidemiol. 2017;27(3):89-97. doi: 10.1016/ [PubMed: 28142039]. [PubMed Central: PMC5363781].
  • 48. Kim K, Vance TM, Chun OK. Greater total antioxidant capacity from diet and supplements is associated with a less atherogenic blood profile in U.S. adults. Nutrients. 2016;8(1). doi: 10.3390/nu8010015. [PubMed: 26742057]. [PubMed Central: PMC4728629].
  • 49. Chen W, Mao L, Xing H, Xu L, Fu X, Huang L, et al. Lycopene attenuates Abeta1-42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease. Neurosci Lett. 2015;608:28-33. doi: 10.1016/j.neulet.2015.10.009. [PubMed: 26453763].
  • 50. Ientile L, De Pasquale R, Monacelli F, Odetti P, Traverso N, Cammarata S, et al. Survival rate in patients affected by dementia followed by memory clinics (UVA) in Italy. J Alzheimers Dis. 2013;36(2):303-9. doi: 10.3233/JAD-130002. [PubMed: 23609761].
  • 51. Alles B, Samieri C, Feart C, Jutand MA, Laurin D, Barberger-Gateau P. Dietary patterns: A novel approach to examine the link between nutrition and cognitive function in older individuals. Nutr Res Rev. 2012;25(2):207-22. doi: 10.1017/S0954422412000133. [PubMed: 22874455].
  • 52. Feart C, Samieri C, Alles B, Barberger-Gateau P. Potential benefits of adherence to the Mediterranean diet on cognitive health. Proc Nutr Soc. 2013;72(1):140-52. doi: 10.1017/S0029665112002959. [PubMed: 23228285].
  • 53. Feart C, Letenneur L, Helmer C, Samieri C, Schalch W, Etheve S, et al. Plasma carotenoids are inversely associated with dementia risk in an elderly French cohort. J Gerontol A Biol Sci Med Sci. 2016;71(5):683-8. doi: 10.1093/gerona/glv135. [PubMed: 26286605].
  • 54. Bendich A, Olson JA. Biological actions of carotenoids. FASEB J. 1989;3(8):1927-32. [PubMed: 2656356].
  • 55. Yamada H, Yamada K, Waki M, Umegaki K. Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with and without diabetes complications. Diabetes Care. 2004;27(10):2491-2. [PubMed: 15451922].
  • 56. Ide K, Yamada H, Umegaki K, Mizuno K, Kawakami N, Hagiwara Y, et al. Lymphocyte vitamin C levels as potential biomarker for progression of Parkinson's disease. Nutrition. 2015;31(2):406-8. doi: 10.1016/j.nut.2014.08.001. [PubMed: 25592020].
  • 57. Harrison FE, May JM. Vitamin C function in the brain: Vital role of the ascorbate transporter SVCT2. Free Radic Biol Med. 2009;46(6):719-30. doi: 10.1016/j.freeradbiomed.2008.12.018. [PubMed: 19162177]. [PubMed Central: PMC2649700].
  • 58. Schliebs R, Arendt T. The cholinergic system in aging and neuronal degeneration. Behav Brain Res. 2011;221(2):555-63. doi: 10.1016/j.bbr.2010.11.058. [PubMed: 21145918].
  • 59. Revett TJ, Baker GB, Jhamandas J, Kar S. Glutamate system, amyloid ss peptides and tau protein: Functional interrelationships and relevance to Alzheimer disease pathology. J Psychiatry Neurosci. 2013;38(1):6-23. doi: 10.1503/jpn.110190. [PubMed: 22894822]. [PubMed Central: PMC3529221].
  • 60. Carr AC, Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am J Clin Nutr. 1999;69(6):1086-107. doi: 10.1093/ajcn/69.6.1086. [PubMed: 10357726].
  • 61. Kean RJ, Lamport DJ, Dodd GF, Freeman JE, Williams CM, Ellis JA, et al. Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: An 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. Am J Clin Nutr. 2015;101(3):506-14. doi: 10.3945/ajcn.114.088518. [PubMed: 25733635].
  • 62. Letenneur L, Proust-Lima C, Le Gouge A, Dartigues JF, Barberger-Gateau P. Flavonoid intake and cognitive decline over a 10-year period. Am J Epidemiol. 2007;165(12):1364-71. doi: 10.1093/aje/kwm036. [PubMed: 17369607].
  • 63. Touvier M, Druesne-Pecollo N, Kesse-Guyot E, Andreeva VA, Fezeu L, Galan P, et al. Dual association between polyphenol intake and breast cancer risk according to alcohol consumption level: A prospective cohort study. Breast Cancer Res Treat. 2013;137(1):225-36. doi: 10.1007/s10549-012-2323-y. [PubMed: 23132534].
  • 64. Kesse-Guyot E, Fezeu L, Jeandel C, Ferry M, Andreeva V, Amieva H, et al. French adults' cognitive performance after daily supplementation with antioxidant vitamins and minerals at nutritional doses: A post hoc analysis of the supplementation in vitamins and mineral antioxidants (SU.VI.MAX) trial. Am J Clin Nutr. 2011;94(3):892-9. doi: 10.3945/ajcn.110.007815. [PubMed: 21775560].
  • 65. Kang JH, Cook NR, Manson JE, Buring JE, Albert CM, Grodstein F. Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The women's antioxidant and cardiovascular study. Circulation. 2009;119(21):2772-80. doi: 10.1161/CIRCULATIONAHA.108.816900. [PubMed: 19451353]. [PubMed Central: PMC2752297].
  • 66. Gale CR, Martyn CN, Cooper C. Cognitive impairment and mortality in a cohort of elderly people. BMJ. 1996;312(7031):608-11. [PubMed: 8595334]. [PubMed Central: PMC2350374].
  • 67. Jama JW, Launer LJ, Witteman JC, den Breeijen JH, Breteler MM, Grobbee DE, et al. Dietary antioxidants and cognitive function in a population-based sample of older persons. The rotterdam study. Am J Epidemiol. 1996;144(3):275-80. [PubMed: 8686696].
  • 68. Glaso M, Nordbo G, Diep L, Bohmer T. Reduced concentrations of several vitamins in normal weight patients with late-onset dementia of the Alzheimer type without vascular disease. J Nutr Health Aging. 2004;8(5):407-13. [PubMed: 15359361].
  • 69. Polidori MC, Mecocci P. Plasma susceptibility to free radical-induced antioxidant consumption and lipid peroxidation is increased in very old subjects with Alzheimer disease. J Alzheimer's Dis. 2002;4(6):517-22. doi: 10.3233/jad-2002-4608.
  • 70. Agbayewa MO, Bruce VM, Siemens V. Pyridoxine, ascorbic acid and thiamine in Alzheimer and comparison subjects. Can J Psychiatry. 1992;37(9):661-2. [PubMed: 1477827].
  • 71. Paraskevas GP, Kapaki E, Libitaki G, Zournas C, Segditsa I, Papageorgiou C. Ascorbate in healthy subjects, amyotrophic lateral sclerosis and Alzheimer's disease. Acta Neurol Scand. 1997;96(2):88-90. [PubMed: 9272183].
  • 72. Schippling S, Kontush A, Arlt S, Buhmann C, Sturenburg HJ, Mann U, et al. Increased lipoprotein oxidation in Alzheimer's disease. Free Radic Biol Med. 2000;28(3):351-60. [PubMed: 10699746].
  • 73. Sato R, Helzlsouer KJ, Comstock GW, Hoffman SC, Norkus EP, Fried LP. A cross-sectional study of vitamin C and cognitive function in older adults: The differential effects of gender. J Nutr Health Aging. 2006;10(1):37-44. [PubMed: 16453056].
  • 74. Grosso G, Bei R, Mistretta A, Marventano S, Calabrese G, Masuelli L, et al. Effects of vitamin C on health: A review of evidence. Front Biosci (Landmark Ed). 2013;18:1017-29. [PubMed: 23747864].
  • 75. Butterfield DA, Reed T, Newman SF, Sultana R. Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med. 2007;43(5):658-77. doi: 10.1016/j.freeradbiomed.2007.05.037. [PubMed: 17664130]. [PubMed Central: PMC2031860].
  • 76. Choudhry F, Howlett DR, Richardson JC, Francis PT, Williams RJ. Pro-oxidant diet enhances beta/gamma secretase-mediated APP processing in APP/PS1 transgenic mice. Neurobiol Aging. 2012;33(5):960-8. doi: 10.1016/j.neurobiolaging.2010.07.008. [PubMed: 20724034].
  • 77. Li FJ, Shen L, Ji HF. Dietary intakes of vitamin E, vitamin C, and beta-carotene and risk of Alzheimer's disease: A meta-analysis. J Alzheimers Dis. 2012;31(2):253-8. doi: 10.3233/JAD-2012-120349. [PubMed: 22543848].
  • 78. Kuhad A, Sethi R, Chopra K. Lycopene attenuates diabetes-associated cognitive decline in rats. Life Sci. 2008;83(3-4):128-34. doi: 10.1016/j.lfs.2008.05.013. [PubMed: 18585396].
  • 79. Wang Z, Fan J, Wang J, Li Y, Xiao L, Duan D, et al. Protective effect of lycopene on high-fat diet-induced cognitive impairment in rats. Neurosci Lett. 2016;627:185-91. doi: 10.1016/j.neulet.2016.05.014. [PubMed: 27177726].
  • 80. Mecocci P, Polidori MC, Cherubini A, Ingegni T, Mattioli P, Catani M, et al. Lymphocyte oxidative DNA damage and plasma antioxidants in Alzheimer disease. Arch Neurol. 2002;59(5):794-8. [PubMed: 12020262].
  • 81. Akbaraly NT, Faure H, Gourlet V, Favier A, Berr C. Plasma carotenoid levels and cognitive performance in an elderly population: Results of the EVA study. J Gerontol A Biol Sci Med Sci. 2007;62(3):308-16. [PubMed: 17389729].
  • 82. Prakash A, Kumar A. Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in beta-amyloid induced Alzheimers disease. Eur J Pharmacol. 2014;741:104-11. doi: 10.1016/j.ejphar.2014.07.036. [PubMed: 25066110].
  • 83. Qu M, Li L, Chen C, Li M, Pei L, Chu F, et al. Protective effects of lycopene against amyloid beta-induced neurotoxicity in cultured rat cortical neurons. Neurosci Lett. 2011;505(3):286-90. doi: 10.1016/j.neulet.2011.10.048. [PubMed: 22044877].
  • 84. Stiernagle T. Maintenance of C. elegans (February 11, 2006), WormBook, ed. The C. elegans research community, WormBook. 2006.
  • 85. Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. Vitamin E and cognitive decline in older persons. Arch Neurol. 2002;59(7):1125-32. [PubMed: 12117360].
  • 86. Zaman Z, Roche S, Fielden P, Frost PG, Niriella DC, Cayley AC. Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease. Age Ageing. 1992;21(2):91-4. [PubMed: 1575097].
  • 87. Lee L, Kang SA, Lee HO, Lee BH, Park JS, Kim JH, et al. Relationships between dietary intake and cognitive function level in Korean elderly people. Public Health. 2001;115(2):133-8. doi: 10.1038/sj/ph/1900729. [PubMed: 11406779].
  • 88. Chen YC, Jung CC, Chen JH, Chiou JM, Chen TF, Chen YF, et al. Association of dietary patterns with global and domain-specific cognitive decline in Chinese elderly. J Am Geriatr Soc. 2017;65(6):1159-67. doi: 10.1111/jgs.14741. [PubMed: 28092399].
  • 89. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci. 1999;19(18):8114-21. [PubMed: 10479711].
  • 90. Grodstein F, Kang JH, Glynn RJ, Cook NR, Gaziano JM. A randomized trial of beta carotene supplementation and cognitive function in men: The physicians' health study II. Arch Intern Med. 2007;167(20):2184-90. doi: 10.1001/archinte.167.20.2184. [PubMed: 17998490].
  • 91. Jakobsen LH, Kondrup J, Zellner M, Tetens I, Roth E. Effect of a high protein meat diet on muscle and cognitive functions: A randomised controlled dietary intervention trial in healthy men. Clin Nutr. 2011;30(3):303-11. doi: 10.1016/j.clnu.2010.12.010. [PubMed: 21239090].
  • 92. Masaki KH, Losonczy KG, Izmirlian G, Foley DJ, Ross GW, Petrovitch H, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology. 2000;54(6):1265-72. [PubMed: 10746596].
  • 93. Wind AW, Schellevis FG, Van Staveren G, Scholten RP, Jonker C, Van Eijk JT. Limitations of the mini-mental state examination in diagnosing dementia in general practice. Int J Geriatr Psychiatry. 1997;12(1):101-8. [PubMed: 9050431].

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