Iranian Red Crescent Medical Journal

Published by: Kowsar

Methyl Palmitate Protection Against Isoniazid and Rifampicin-Induced Oxidative Liver Damage

Serdar Kalemci 1 , Aydın Sarihan 2 , * and Yelda Dere 3
Authors Information
1 Tinaztepe Hospital, Chest Disease, Izmir, Turkey
2 Manisa State Hospital, Department of Emergency Medicine, Manisa, Turkey
3 Muggla Sitki Kocman University, School of Medicine, Department of Pathology, Mugla, Turkey
Article information
  • Iranian Red Crescent Medical Journal: May 2018, 20 (5); e60819
  • Published Online: April 17, 2018
  • Article Type: Editorial
  • Received: August 24, 2017
  • Revised: October 18, 2017
  • Accepted: December 20, 2017
  • DOI: 10.5812/ircmj.60819

To Cite: Kalemci S, Sarihan A, Dere Y. Methyl Palmitate Protection Against Isoniazid and Rifampicin-Induced Oxidative Liver Damage, Iran Red Crescent Med J. 2018 ; 20(5):e60819. doi: 10.5812/ircmj.60819.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
  • 1. Nanashima K, Mawatari T, Tahara N, Higuchi N, Nakaura A, Inamine T, et al. Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients. Tuberculosis (Edinb). 2012;92(3):253-9. doi: 10.1016/ [PubMed: 22341855].
  • 2. Lough AK, Felinski L, Garton GA. The production of methyl esters of fatty acids as artifacts during the extraction or storage of tissue lipids in the presence of methanol. J Lipid Res. 1962;3(4):478-80.
  • 3. Sarkar S, Khan MF, Kaphalia BS, Ansari GA. Methyl palmitate inhibits lipopolysaccharide-stimulated phagocytic activity of rat peritoneal macrophages. J Biochem Mol Toxicol. 2006;20(6):302-8. doi: 10.1002/jbt.20150. [PubMed: 17163484].
  • 4. El-Demerdash E. Anti-inflammatory and antifibrotic effects of methyl palmitate. Toxicol Appl Pharmacol. 2011;254(3):238-44. doi: 10.1016/j.taap.2011.04.016. [PubMed: 21575650].
  • 5. Lian Y, Zhao J, Xu P, Wang Y, Zhao J, Jia L, et al. Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice. PLoS One. 2013;8(8). e72058. doi: 10.1371/journal.pone.0072058. [PubMed: 23967274].
  • 6. Ashcroft T, Simpson JM, Timbrell V. Simple method of estimating severity of pulmonary fibrosis on a numerical scale. J Clin Pathol. 1988;41(4):467-70. [PubMed: 3366935].
  • 7. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990;186:421-31. [PubMed: 2233309].
  • 8. Aebi H. Methods of enzymatic analysis. Academic Press; 1974. doi: 10.1016/b978-0-12-091302-2.50032-3.
  • 9. Shoeib AM, Said E, Ammar EM. Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury. Can J Physiol Pharmacol. 2015:1-8. doi: 10.1139/cjpp-2015-0270. [PubMed: 26569614].
  • 10. Gunawardhana L, Mobley SA, Sipes IG. Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. Toxicol Appl Pharmacol. 1993;119(2):205-13. doi: 10.1006/taap.1993.1061. [PubMed: 8386865].

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