Iranian Red Crescent Medical Journal

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Umbilical Cord Blood Acidosis in Term Pregnancies With Gestational Diabetes Mellitus and Its Relations to Maternal Factors and Neonatal Outcomes

Soroush Aalipour 1 , Sedigheh Hantoushzadeh 1 , 2 , Mamak Shariat 2 , Sadaf Sahraian 1 and Mahdi Sheikh 1 , 2 , *
Authors Information
1 Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
2 Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: December 2018, 20 (S1); e59267
  • Published Online: February 24, 2018
  • Article Type: Research Article
  • Received: July 31, 2017
  • Revised: October 17, 2017
  • Accepted: November 18, 2017
  • DOI: 10.5812/ircmj.59267

To Cite: Aalipour S, Hantoushzadeh S, Shariat M, Sahraian S, Sheikh M. Umbilical Cord Blood Acidosis in Term Pregnancies With Gestational Diabetes Mellitus and Its Relations to Maternal Factors and Neonatal Outcomes, Iran Red Crescent Med J. 2018 ; 20(S1):e59267. doi: 10.5812/ircmj.59267.

Copyright © 2018, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Lassi ZS, Middleton PF, Crowther C, Bhutta ZA. Interventions to Improve Neonatal Health and Later Survival: An Overview of Systematic Reviews. EBioMedicine. 2015;2(8):985-1000. doi: 10.1016/j.ebiom.2015.05.023. [PubMed: 26425706].
  • 2. James LS, Weisbrot IM, Prince CE, Holaday DA, Apgar V. The acid-base status of human infants in relation to birth asphyxia and the onset of respiration. J Pediatr. 1958;52(4):379-94.
  • 3. Armstrong L, Stenson BJ. Use of umbilical cord blood gas analysis in the assessment of the newborn. Arch Dis Child Fetal Neonatal Ed. 2007;92(6):F430-4. doi: 10.1136/adc.2006.099846. [PubMed: 17951550].
  • 4. Acog Committee on Obstetric Practice . ACOG Committee Opinion No. 348, November 2006: Umbilical cord blood gas and acid-base analysis. Obstet Gynecol. 2006;108(5):1319-22. [PubMed: 17077266].
  • 5. Malin GL, Morris RK, Khan KS. Strength of association between umbilical cord pH and perinatal and long term outcomes: systematic review and meta-analysis. BMJ. 2010;340:c1471. doi: 10.1136/bmj.c1471. [PubMed: 20466789].
  • 6. Victory R, Penava D, da Silva O, Natale R, Richardson B. Umbilical cord pH and base excess values in relation to neonatal morbidity for infants delivered preterm. Am J Obstet Gynecol. 2003;189(3):803-7.
  • 7. Yeh P, Emary K, Impey L. The relationship between umbilical cord arterial pH and serious adverse neonatal outcome: analysis of 51,519 consecutive validated samples. BJOG. 2012;119(7):824-31. doi: 10.1111/j.1471-0528.2012.03335.x. [PubMed: 22571747].
  • 8. Beneventi F, Locatelli E, Cavagnoli C, Simonetta M, Lovati E, Lucotti P, et al. Effects of uncomplicated vaginal delivery and epidural analgesia on fetal arterial acid-base parameters at birth in gestational diabetes. Diabetes Res Clin Pract. 2014;103(3):444-51. doi: 10.1016/j.diabres.2013.12.019. [PubMed: 24529563].
  • 9. Krielessi V, Papantoniou N, Papageorgiou I, Chatzipapas I, Manios E, Zakopoulos N, et al. Placental Pathology and Blood Pressure's Level in Women with Hypertensive Disorders in Pregnancy. Obstet Gynecol Int. 2012;2012:684083. doi: 10.1155/2012/684083. [PubMed: 22645615].
  • 10. Sheikh M, Zoham MH, Hantoushzadeh S, Shariat M, Dalili H, Amini E. Umbilical blood gas analysis in preeclamptic versus healthy pregnancies with preterm birth. J Matern Fetal Neonatal Med. 2016;29(15):2549-54. doi: 10.3109/14767058.2015.1094786. [PubMed: 26444051].
  • 11. Bobrow CS, Soothill PW. Causes and consequences of fetal acidosis. Arch Dis Child Fetal Neonatal Ed. 1999;80(3):F246-9. [PubMed: 10212094].
  • 12. Stevens AD, Lumbers ER. Effects of reduced uterine blood flow on fetal cardiovascular, renal, and lung function. Am J Physiol. 1990;259(5 Pt 2):R1004-11. doi: 10.1152/ajpregu.1990.259.5.R1004. [PubMed: 2240260].
  • 13. Desoye G, Hauguel-de Mouzon S. The human placenta in gestational diabetes mellitus. The insulin and cytokine network. Diabetes Care. 2007;30 Suppl 2:S120-6. doi: 10.2337/dc07-s203. [PubMed: 17596459].
  • 14. Taricco E, Radaelli T, Rossi G, Nobile de Santis MS, Bulfamante GP, Avagliano L, et al. Effects of gestational diabetes on fetal oxygen and glucose levels in vivo. BJOG. 2009;116(13):1729-35. doi: 10.1111/j.1471-0528.2009.02341.x. [PubMed: 19832834].
  • 15. Salvesen DR, Brudenell JM, Proudler AJ, Crook D, Nicolaides KH. Fetal pancreatic beta-cell function in pregnancies complicated by maternal diabetes mellitus: relationship to fetal acidemia and macrosomia. Am J Obstet Gynecol. 1993;168(5):1363-9.
  • 16. Committee opinion no. 504: Screening and diagnosis of gestational diabetes mellitus. Obstet Gynecol. 2011;118(3):751-3. doi: 10.1097/AOG.0b013e3182310cc3. [PubMed: 21860317].
  • 17. Suidan JS, Young BK. Acidosis in the vigorous newborn. Obstet Gynecol. 1985;65(3):361-4. [PubMed: 3919346].
  • 18. American Academy of Pediatrics Subcommittee on H. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004;114(1):297-316. [PubMed: 15231951].
  • 19. Jarmuzek P, Wielgos M, Bomba-Opon D. Placental pathologic changes in gestational diabetes mellitus. Neuro Endocrinol Lett. 2015;36(2):101-5. [PubMed: 26071574].
  • 20. Hantoushzadeh S, Sheikh M, Bosaghzadeh Z, Ghotbizadeh F, Tarafdari A, Panahi Z, et al. The impact of gestational weight gain in different trimesters of pregnancy on glucose challenge test and gestational diabetes. Postgrad Med J. 2016;92(1091):520-4. doi: 10.1136/postgradmedj-2015-133816. [PubMed: 26929392].
  • 21. Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991-2002. doi: 10.1056/NEJMoa0707943. [PubMed: 18463375].
  • 22. Langer O, Anyaegbunam A, Brustman L, Divon M. Management of women with one abnormal oral glucose tolerance test value reduces adverse outcome in pregnancy. Am J Obstet Gynecol. 1989;161(3):593-9.
  • 23. Sermer M, Naylor CD, Gare DJ, Kenshole AB, Ritchie JW, Farine D, et al. Impact of increasing carbohydrate intolerance on maternal-fetal outcomes in 3637 women without gestational diabetes. The Toronto Tri-Hospital Gestational Diabetes Project. Am J Obstet Gynecol. 1995;173(1):146-56.
  • 24. Casey BM, Lucas MJ, McIntire DD, Leveno KJ. Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol. 1997;90(6):869-73.
  • 25. Lucas MJ. Diabetes complicating pregnancy. Obstet Gynecol Clin North Am. 2001;28(3):513-36.
  • 26. Ballard JL, Rosenn B, Khoury JC, Miodovnik M. Diabetic fetal macrosomia: significance of disproportionate growth. J Pediatr. 1993;122(1):115-9.
  • 27. Flores-le Roux JA, Sagarra E, Benaiges D, Hernandez-Rivas E, Chillaron JJ, Puig de Dou J, et al. A prospective evaluation of neonatal hypoglycaemia in infants of women with gestational diabetes mellitus. Diabetes Res Clin Pract. 2012;97(2):217-22. doi: 10.1016/j.diabres.2012.03.011. [PubMed: 22537519].
  • 28. Hawdon JM. Babies born after diabetes in pregnancy: what are the short- and long-term risks and how can we minimise them? Best Pract Res Clin Obstet Gynaecol. 2011;25(1):91-104. doi: 10.1016/j.bpobgyn.2010.10.005. [PubMed: 21237719].
  • 29. Brans YW, Huff RW, Shannon DL, Hunter MA. Maternal diabetes and neonatal macrosomia. I. Postpartum maternal hemoglobin A1c levels and neonatal hypoglycemia. Pediatrics. 1982;70(4):576-81. [PubMed: 7122156].
  • 30. Stevenson DK, Ostrander CR, Hopper AO, Cohen RS, Johnson JD. Pulmonary excretion of carbon monoxide as an index of bilirubin production. IIa. Evidence for possible delayed clearance of bilirubin in infants of diabetic mothers. J Pediatr. 1981;98(5):822-4.

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