Iranian Red Crescent Medical Journal

Published by: Kowsar

Molecular Epidemiology of Kaposi’s Sarcoma-Associated Herpes Virus, and Risk Factors in HIV-infected Patients in Tehran, 2014

Khashayar Hesamizadeh 1 , 2 , Hossein Keyvani 1 , Farah Bokharaei-Salim 1 , 3 , Seyed Hamidreza Monavari 1 , Maryam Esghaei 1 , * and Fatemeh Jahanbakhsh Sefidi 4
Authors Information
1 Department of Virology, Iran University of Medical Sciences, Tehran, IR Iran
2 Middle East Liver Diseases (MELD) Center, Tehran, IR Iran
3 HIV Laboratory of National Center, Deputy of Health, Iran University of Medical Sciences, Tehran, IR Iran
4 Department of Virology, Pasteur Institute of Iran, Tehran, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: November 2016, 18 (11); e59048
  • Published Online: June 19, 2016
  • Article Type: Research Article
  • Received: August 23, 2015
  • Revised: October 26, 2015
  • Accepted: November 24, 2015
  • DOI: 10.5812/ircmj.32603

To Cite: Hesamizadeh K, Keyvani H, Bokharaei-Salim F, Monavari S H, Esghaei M, et al. Molecular Epidemiology of Kaposi’s Sarcoma-Associated Herpes Virus, and Risk Factors in HIV-infected Patients in Tehran, 2014, Iran Red Crescent Med J. 2016 ; 18(11):e59048. doi: 10.5812/ircmj.32603.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994; 266(5192): 1865-9[PubMed]
  • 2. Klepfish A, Zuckermann B, Schattner A. Primary effusion lymphoma in the absence of HIV infection--clinical presentation and management. QJM. 2015; 108(6): 481-8[DOI][PubMed]
  • 3. Carbone A, De Paoli P, Gloghini A, Vaccher E. KSHV-associated multicentric Castleman disease: A tangle of different entities requiring multitarget treatment strategies. Int J Cancer. 2015; 137(2): 251-61[DOI][PubMed]
  • 4. Dittmer DP, Damania B. Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update. Curr Opin Virol. 2013; 3(3): 238-44[DOI][PubMed]
  • 5. Gramolelli S, Schulz TF. The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma. J Pathol. 2015; 235(2): 368-80[DOI][PubMed]
  • 6. Pica F, Volpi A. Transmission of human herpesvirus 8: an update. Curr Opin Infect Dis. 2007; 20(2): 152-6[DOI][PubMed]
  • 7. Bagni R, Whitby D. Kaposi's sarcoma-associated herpesvirus transmission and primary infection. Curr Opin HIV AIDS. 2009; 4(1): 22-6[DOI][PubMed]
  • 8. Minhas V, Wood C. Epidemiology and transmission of Kaposi's sarcoma-associated herpesvirus. Viruses. 2014; 6(11): 4178-94[DOI][PubMed]
  • 9. Jaffe HW, De Stavola BL, Carpenter LM, Porter K, Cox DR, Cascade Collaboration . Immune reconstitution and risk of Kaposi sarcoma and non-Hodgkin lymphoma in HIV-infected adults. AIDS. 2011; 25(11): 1395-403[DOI][PubMed]
  • 10. Cavallin LE, Goldschmidt-Clermont P, Mesri EA. Molecular and cellular mechanisms of KSHV oncogenesis of Kaposi's sarcoma associated with HIV/AIDS. PLoS Pathog. 2014; 10(7)[DOI][PubMed]
  • 11. La Ferla L, Pinzone MR, Nunnari G, Martellotta F, Lleshi A, Tirelli U, et al. Kaposi' s sarcoma in HIV-positive patients: the state of art in the HAART-era. Eur Rev Med Pharmacol Sci. 2013; 17(17): 2354-65[PubMed]
  • 12. Wang J, Liu S, Cao Y, Yang L, Chen Y, Minhas V, et al. Prevalence of Kaposi's sarcoma associated herpesvirus among men attending sexually transmitted infections clinics in Anhui, China. J Med Virol. 2016; 88(2): 304-11[DOI][PubMed]
  • 13. Uldrick TS, Whitby D. Update on KSHV epidemiology, Kaposi Sarcoma pathogenesis, and treatment of Kaposi Sarcoma. Cancer Lett. 2011; 305(2): 150-62[DOI][PubMed]
  • 14. Krown SE. Management of AIDS-Related Kaposi Sarcoma. Cancers in People with HIV and AIDS. 2014; : 139-52
  • 15. Labo N, Miley W, Benson CA, Campbell TB, Whitby D. Epidemiology of Kaposi's sarcoma-associated herpesvirus in HIV-1-infected US persons in the era of combination antiretroviral therapy. AIDS. 2015; 29(10): 1217-25[DOI][PubMed]
  • 16. Olp LN, Minhas V, Gondwe C, Kankasa C, Wojcicki J, Mitchell C, et al. Effects of Antiretroviral Therapy on Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Transmission Among HIV-Infected Zambian Children. J Natl Cancer Inst. 2015; 107(10)[DOI][PubMed]
  • 17. Keyvani H, Bokharaei-Salim F, Monavari SH, Esghaei M, Nassiri Toosi M, Fakhim S, et al. Occult hepatitis C virus infection in candidates for liver transplant with cryptogenic cirrhosis. Hepat Mon. 2013; 13(8)[DOI][PubMed]
  • 18. Ghane M, Eghbali M. Polymerase chain reaction for detection of Kaposi’s sarcoma virus in breast tumors. J Paramed Sci. 2015; 6(2)
  • 19. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. 1989; 2
  • 20. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, et al. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988; 239(4839): 487-91[PubMed]
  • 21. Albrecht D, Meyer T, Lorenzen T, Stoehr A, Arndt R, Plettenberg A. Epidemiology of HHV-8 infection in HIV-positive patients with and without Kaposi sarcoma: diagnostic relevance of serology and PCR. J Clin Virol. 2004; 30(2): 145-9[DOI][PubMed]
  • 22. Martro E, Esteve A, Schulz TF, Sheldon J, Gambus G, Munoz R, et al. Risk factors for human Herpesvirus 8 infection and AIDS-associated Kaposi's sarcoma among men who have sex with men in a European multicentre study. Int J Cancer. 2007; 120(5): 1129-35[DOI][PubMed]
  • 23. Alavi SM, Moradzadegan H, Khoshkhoy MM. Seroprevalence of HIV in Newly Detected Pulmonary Tuberculosis Patients in Khuzestan, Iran: Should HIV Testing Be Included in National Tuberculosis Program in This Region? Jundishapur J Microbiol. 2013; 6(2): 193-6
  • 24. Shushtari ZJ, Sajjadi H, Forouzan AS, Salimi Y, Dejman M. Disclosure of HIV status and social support among people living with HIV. Iran Red Crescent Med J. 2014; 16(8)[DOI]
  • 25. Bokharaei-Salim F, Keyvani H, Esghaei M, Zare S, et al. Prevalence of occult hepatitis C virus infection in the Iranian patients with human immunodeficiency virus infection. J Med Virol. 2016; [DOI]
  • 26. Hesamizadeh K, Sharafi H, Rezaee-Zavareh MS, Behnava B, Alavian SM. Next steps toward eradication of hepatitis C in the era of direct acting antivirals. Hepat Mon. 2016; 16(4)[DOI]
  • 27. Jalilvand S, Shoja Z, Mokhtari-Azad T, Nategh R, Gharehbaghian A. Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran. Infect Agent Cancer. 2011; 6: 5[DOI][PubMed]
  • 28. Meidani M, Aminzadeh Z, Faghih M, Ahmadi N. Are the preventive services for HHV-8 necessary in HIV positive persons in central zone of Iran? Iran J Pathol. 2014; 9(2): 133-7
  • 29. Dukers NH, Rezza G. Human herpesvirus 8 epidemiology: what we do and do not know. AIDS. 2003; 17(12): 1717-30
  • 30. Karli B, Onel M, Eraksoy H, Agacfidan A. [Investigation of HHV-8 prevalence in anti-HIV-1 positive patients in Istanbul, Turkey]. Mikrobiyol Bul. 2013; 47(3): 493-9[PubMed]
  • 31. Szalai E, Gerlei Z, Szlavik J, Szladek G, Patel R, Hunyadi J, et al. Prevalence of human herpesvirus-8 infection in HIV-positive patients with and without Kaposi's sarcoma in Hungary. FEMS Immunol Med Microbiol. 2005; 43(2): 265-8[DOI][PubMed]
  • 32. Renwick N, Dukers NH, Weverling GJ, Sheldon JA, Schulz TF, Prins M, et al. Risk factors for human herpesvirus 8 infection in a cohort of drug users in the Netherlands, 1985-1996. J Infect Dis. 2002; 185(12): 1808-12[DOI][PubMed]
  • 33. National Center for HIV, STD, and TB Prevention, Division of HIV/AIDS Prevention. 2014;
  • 34. Perkins EL, Stennis KB, Taylor Spriggs V, Kwegyir-Afful EA, Prather A. Is Knowledge Enough? Considering HIV/AIDS Risk Behaviors and HIV/AIDS Knowledge with African American Women. Int J High Risk Behav Addict. 2014; 3(3)[DOI][PubMed]
  • 35. Mumtaz GR, Weiss HA, Thomas SL, Riome S, Setayesh H, Riedner G, et al. HIV among people who inject drugs in the Middle East and North Africa: systematic review and data synthesis. PLoS Med. 2014; 11(6)[DOI][PubMed]
  • 36. Plancoulaine S, Abel L, van Beveren M, Tregouet DA, Joubert M, Tortevoye P, et al. Human herpesvirus 8 transmission from mother to child and between siblings in an endemic population. Lancet. 2000; 356(9235): 1062-5[DOI][PubMed]
  • 37. Brayfield BP, Kankasa C, West JT, Muyanga J, Bhat G, Klaskala W, et al. Distribution of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 in maternal saliva and breast milk in Zambia: implications for transmission. J Infect Dis. 2004; 189(12): 2260-70[DOI][PubMed]
  • 38. Crabtree KL, Wojcicki JM, Minhas V, Smith DR, Kankasa C, Mitchell CD, et al. Risk factors for early childhood infection of human herpesvirus-8 in Zambian children: the role of early childhood feeding practices. Cancer Epidemiol Biomarkers Prev. 2014; 23(2): 300-8[DOI][PubMed]
  • 39. Zong J, Ciufo DM, Viscidi R, Alagiozoglou L, Tyring S, Rady P, et al. Genotypic analysis at multiple loci across Kaposi's sarcoma herpesvirus (KSHV) DNA molecules: clustering patterns, novel variants and chimerism. J Clin Virol. 2002; 23(3): 119-48[PubMed]
  • 40. Hosseini-Moghaddam SM, Keyvani H, Soleimanirahbar A, Karimi G, Daneshvar S, Basiri A, et al. The frequency of HHV-8 infection in otherwise healthy blood donors as well as renal allograft recipients living in Iran. Arch Iran Med. 2013; 16(7): 376-9[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments