Iranian Red Crescent Medical Journal

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The Effect of Evening Primrose Oil on the Intensity of Postpartum Blues Among Primiparous Females: A Double-blind, Randomized, Controlled Clinical Trial

Soghra Nikoomazhab 1 , Parvin Abedi 2 , Azam Honarmandpour 3 , * and Mohammad Reza Haghdoust 4
Authors Information
1 Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Midwifery, Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
4 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Iranian Red Crescent Medical Journal: July 2018, 20 (7); e58468
  • Published Online: February 10, 2018
  • Article Type: Research Article
  • Received: April 22, 2017
  • Revised: July 22, 2017
  • Accepted: September 5, 2017
  • DOI: 10.5812/ircmj.58468

To Cite: Nikoomazhab S, Abedi P, Honarmandpour A, Haghdoust M R. The Effect of Evening Primrose Oil on the Intensity of Postpartum Blues Among Primiparous Females: A Double-blind, Randomized, Controlled Clinical Trial, Iran Red Crescent Med J. 2018 ; 20(7):e58468. doi: 10.5812/ircmj.58468.

Copyright © 2018, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Henshaw C. Mood disturbance in the early puerperium: a review. Arch Womens Ment Health. 2003;6 Suppl 2:S33-42. doi: 10.1007/s00737-003-0004-x. [PubMed: 14615921].
  • 2. Cunningham G, Leveno K, Bloom S, Spong C, Dashe J, Hoffman B. Williams Obstetrics. 24th ed. McGraw hill; 2014. 1434 p.
  • 3. Sagsoz N, Oguzturk O, Bayram M, Kamaci M. Anxiety and depression before and after the menopause. Arch Gynecol Obstet. 2001;264(4):199-202. doi: 10.1007/s004040000108. [PubMed: 11205708].
  • 4. Faisal-Cury A, Menezes PR, Tedesco JJ, Kahalle S, Zugaib M. Maternity "blues": prevalence and risk factors. Span J Psychol. 2008;11(2):593-9. [PubMed: 18988444].
  • 5. Kaplan HI, Sadock BJ. Synopsis of psychiatry: Behavioral sciences clinical psychiatry. Baltimore: Williams & Wilkins Co; 1988. 725 p.
  • 6. M'Bailara K, Swendsen J, Glatigny-Dallay E, Dallay D, Roux D, Sutter AL, et al. [Baby blues: characterization and influence of psycho-social factors]. Encephale. 2005;31(3):331-6. [PubMed: 16142048].
  • 7. Held L, Rutherford A. Can't a mother sing the blues? Postpartum depression and the construction of motherhood in late 20th-century America. Hist Psychol. 2012;15(2):107-23. doi: 10.1037/a0026219. [PubMed: 22849002].
  • 8. Righetti-Veltema M, Conne-Perreard E, Bousquet A, Manzano J. Postpartum depression and mother-infant relationship at 3 months old. J Affect Disord. 2002;70(3):291-306. doi: 10.1016/S0165-0327(01)00367-6. [PubMed: 12128241].
  • 9. Dashte Bozorgi B, Ghadirian F, Khaje- Aldin N, Karami K. he impact of family psych education on the course of recovery of patients with mood disorders [In Persian]. Iran J Psychiatry Clin Psychol. 2009;15(2):193-200.
  • 10. Wanjirw M. Using medication and therapy to manage postpartum depression. 2010.
  • 11. Desai AK, Grossberg GT. Herbals and botanicals in geriatric psychiatry. Am J Geriatr Psychiatry. 2003;11(5):498-506. doi: 10.1097/00019442-200309000-00004. [PubMed: 14506083].
  • 12. Blommers J, de Lange-De Klerk ES, Kuik DJ, Bezemer PD, Meijer S. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Am J Obstet Gynecol. 2002;187(5):1389-94. doi: 10.1067/mob.2002.127377a. [PubMed: 12439536].
  • 13. Hibbeln JR, Salem NJ. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr. 1995;62(1):1-9. doi: 10.1093/ajcn/62.1.1. [PubMed: 7598049].
  • 14. Kasper S, Anghelescu IG, Szegedi A, Dienel A, Kieser M. Placebo controlled continuation treatment with Hypericum extract WS 5570 after recovery from a mild or moderate depressive episode. Wien Med Wochenschr. 2007;157(13-14):362-6. doi: 10.1007/s10354-007-0441-7. [PubMed: 17704988].
  • 15. Braun L, Cohen M. Herbs and natural supplements, an evidence-based guide. Elsevier Health Sciences; 2015.
  • 16. Bayles B, Usatine R. Evening primrose oil. Am Fam Physician. 2009;80(12):1405-8. [PubMed: 20000302].
  • 17. Nhs . Pre-eclampsia: preventing pre-eclampsia. 2009. Available from:
  • 18. Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry. 2006;163(6):1098-100. doi: 10.1176/ajp.2006.163.6.1098. [PubMed: 16741212].
  • 19. Saaki M, Jariani M, Saaki K, Delfan B, Tarahi MJ, Gholami M. Effect of primose oil in Treatment of depression in depressed patients referred to a psychiatric clinic in Khorramabad [In Persian]. J Ilam Univ Med Sci. 2008;16(4):46-54.
  • 20. Derogatis LR, Lipman RS, Covi L. SCL-90: an outpatient psychiatric rating scale--preliminary report. Psychopharmacol Bull. 1973;9(1):13-28. [PubMed: 4682398].
  • 21. Najarian B, Davoodi I. Preparation and validation of SCL-25 (Short form of SCL-90-R). J Psychol. 2001;18:250-61.
  • 22. Goldberg DP, Hillier VF. A scaled version of the General Health Questionnaire. Psychol Med. 1979;9(1):139-45. doi: 10.1017/S0033291700021644. [PubMed: 424481].
  • 23. Noor Bala A, Bageri Yazdi SA, Kazem M. Validation 28-item general health questionnaire az a screening tool for phychiatric disorders in Tehran [In Persian]. Hakim Med J. 2008;11(4):47-53.
  • 24. Dennis CL. Can we identify mothers at risk for postpartum depression in the immediate postpartum period using the Edinburgh Postnatal Depression Scale? J Affect Disord. 2004;78(2):163-9. doi: 10.1016/S0165-0327(02)00299-9. [PubMed: 14706728].
  • 25. Logan AC. Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. Altern Med Rev. 2003;8(4):410-25. [PubMed: 14653768].
  • 26. Caballero-Martinez F, Leon-Vazquez F, Paya-Pardo A, Diaz-Holgado A. Use of health care resources and loss of productivity in patients with depressive disorders seen in Primary Care: INTERDEP Study. Actas Esp Psiquiatr. 2014;42(6):281-91. [PubMed: 25388770].
  • 27. Lopresti AL. A review of nutrient treatments for paediatric depression. J Affect Disord. 2015;181:24-32. doi: 10.1016/j.jad.2015.04.014. [PubMed: 25913919].
  • 28. Evian Bagha R, Norousi Panahi L, Ghojazadeh M, Ranjbar Kochaksaraee F, Ebrahimi Mamghani M. Comparison of the efficacy of omega-3 fatty acids with placebo in the treatment of mild to moderate depression at postpartum [In Persian]. J Ardabil Univ Med Sci Health Serv. 2009;9(1):23-32.
  • 29. Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial. Eur Neuropsychopharmacol. 2003;13(4):267-71. doi: 10.1016/S0924-977X(03)00032-4. [PubMed: 12888186].
  • 30. Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry. 2010;68(2):140-7. doi: 10.1016/j.biopsych.2010.03.018. [PubMed: 20452573].
  • 31. Einvik G, Ekeberg O, Lavik JG, Ellingsen I, Klemsdal TO, Hjerkinn EM. The influence of long-term awareness of hyperlipidemia and of 3 years of dietary counseling on depression, anxiety, and quality of life. J Psychosom Res. 2010;68(6):567-72. doi: 10.1016/j.jpsychores.2009.11.004. [PubMed: 20488274].
  • 32. Fathizadeh N, Takfallah L, Ehsanpour S, Namnabati M, Askari S. Effects of evening primrose oil and vitamin E on the severity of periodical breast pain. Iran J Nurs Midwifery Res. 2008;13:90-3.
  • 33. Freeman MP, Hibbeln JR, Wisner KL, Brumbach BH, Watchman M, Gelenberg AJ. Randomized dose-ranging pilot trial of omega-3 fatty acids for postpartum depression. Acta Psychiatr Scand. 2006;113(1):31-5. doi: 10.1111/j.1600-0447.2005.00660.x. [PubMed: 16390366].
  • 34. Gallagher S. Omega 3 oils and pregnancy. Midwifery Today Int Midwife. 2004;(69):26-31. [PubMed: 15124319].
  • 35. Doornbos B, van Goor SA, Dijck-Brouwer DA, Schaafsma A, Korf J, Muskiet FA. Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(1):49-52. doi: 10.1016/j.pnpbp.2008.10.003. [PubMed: 18955102].

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