Iranian Red Crescent Medical Journal

Published by: Kowsar

Cytomegalovirus as a Seldom Cause of Non-Immune Hydrops Fetalis: Case Report and Review of the Literature

Seda Yilmaz Semerci 1 , * , Aslan Babayigit 1 , Burcu Cebeci 1 , Gokhan Buyukkale 2 and Merih Cetinkaya 3
Authors Information
1 MD, Postdoctoral Fellow of Neonatalogy, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Division of Neonatology, Istanbul, Turkey
2 MD, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Division of Neonatology, Istanbul, Turkey
3 MD, PhD, Associate Professor of Pediatrics, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Chief of Neonatology, Istanbul, Turkey
Article information
  • Iranian Red Crescent Medical Journal: August 2017, 19 (8); e55570
  • Published Online: August 22, 2017
  • Article Type: Case Report
  • Received: November 21, 2016
  • Revised: December 15, 2016
  • Accepted: May 2, 2017
  • DOI: 10.5812/ircmj.55570

To Cite: Yilmaz Semerci S, Babayigit A, Cebeci B, Buyukkale G, Cetinkaya M. Cytomegalovirus as a Seldom Cause of Non-Immune Hydrops Fetalis: Case Report and Review of the Literature, Iran Red Crescent Med J. 2017 ; 19(8):e55570. doi: 10.5812/ircmj.55570.

Copyright © 2017, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Report
3. Discussion
  • 1. Barron SD, Pass RF. Infectious causes of hydrops fetalis. Semin Perinatol. 1995; 19(6): 493-501[PubMed]
  • 2. Desilets V, Audibert F, Society of O, Gynaecologists of C. Investigation and management of non-immune fetal hydrops. J Obstet Gynaecol Can. 2013; 35(10): 923-38[PubMed]
  • 3. Bellini C, Donarini G, Paladini D, Calevo MG, Bellini T, Ramenghi LA, et al. Etiology of non-immune hydrops fetalis: An update. Am J Med Genet A. 2015; 167A(5): 1082-8[DOI][PubMed]
  • 4. Rawlinson WD, Hamilton ST, van Zuylen WJ. Update on treatment of cytomegalovirus infection in pregnancy and of the newborn with congenital cytomegalovirus. Curr Opin Infect Dis. 2016; 29(6): 615-24[DOI][PubMed]
  • 5. Jackups R, Mehrad M. Circulating mitotic figures in CMV-associated hydrops fetalis. Blood. 2012; 119(14): 3201[PubMed]
  • 6. Ornoy A, Diav-Citrin O. Fetal effects of primary and secondary cytomegalovirus infection in pregnancy. Reprod Toxicol. 2006; 21(4): 399-409[DOI][PubMed]
  • 7. Beksac MS, Saygan-Karamursel B, Ustacelebi S, Altinok G, Dalva K, Erdinc S, et al. Prenatal diagnosis of intrauterine cytomegalovirus infection in a fetus with non-immune hydrops fetalis. Acta Obstet Gynecol Scand. 2001; 80(8): 762-5[PubMed]
  • 8. Inoue T, Matsumura N, Fukuoka M, Sagawa N, Fujii S. Severe congenital cytomegalovirus infection with fetal hydrops in a cytomegalovirus-seropositive healthy woman. Eur J Obstetr Gynecol Reprod Biol. 2001; 95(2): 184-6[DOI]
  • 9. Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007; 17(4): 253-76[DOI][PubMed]
  • 10. Ko HM, Kim KS, Park JW, Lee YJ, Lee MY, Lee MC, et al. Congenital cytomegalovirus infection: three autopsy case reports. J Korean Med Sci. 2000; 15(3): 337-42[DOI][PubMed]
  • 11. Sampath V, Narendran V, Donovan EF, Stanek J, Schleiss MR. Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant. J Perinatol. 2005; 25(9): 608-11[DOI][PubMed]
  • 12. Ortiz JU, Ostermayer E, Fischer T, Kuschel B, Rudelius M, Schneider KT. Severe fetal cytomegalovirus infection associated with cerebellar hemorrhage. Ultrasound Obstet Gynecol. 2004; 23(4): 402-6[DOI][PubMed]
  • 13. Lujan-Zilbermann J, Lacson A, Gilbert-Barness E, Pomerance HH. Clinico-pathologic conference: newborn with hydrops fetalis caused by CMV infection case report. Pediatr Pathol Mol Med. 2003; 22(6): 481-94[PubMed]
  • 14. Tongsong T, Sukpan K, Wanapirak C, Phadungkiatwattna P. Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: case report. Fetal Diagn Ther. 2008; 23(3): 169-72[DOI][PubMed]
  • 15. Moxley K, Knudtson EJ. Resolution of hydrops secondary to cytomegalovirus after maternal and fetal treatment with human cytomegalovirus hyperimmune globulin. Obstet Gynecol. 2008; 111(2 Pt 2): 524-6[DOI][PubMed]
  • 16. Sato A, Hirano H, Miura H, Hosoya N, Ogawa M, Tanaka T. Intrauterine therapy with cytomegalovirus hyperimmunoglobulin for a fetus congenitally infected with cytomegalovirus. J Obstet Gynaecol Res. 2007; 33(5): 718-21[DOI][PubMed]
  • 17. Takci S, Gharibzadeh M, Yurdakok M, Ozyuncu O, Korkmaz A, Akcoren Z, et al. Etiology and outcome of hydrops fetalis: report of 62 cases. Pediatr Neonatol. 2014; 55(2): 108-13[DOI][PubMed]
  • 18. Laifer SA, Ehrlich GD, Huff DS, Balsan MJ, Scantlebury VP. Congenital cytomegalovirus infection in offspring of liver transplant recipients. Clin Infect Dis. 1995; 20(1): 52-5[PubMed]
  • 19. Salmaso R, Franco R, de Santis M, Carollo C, Suma V, Righini A, et al. Early detection by magnetic resonance imaging of fetal cerebral damage in a fetus with hydrops and cytomegalovirus infection. J Matern Fetal Neonatal Med. 2007; 20(7): 559-61[DOI][PubMed]
  • 20. Syridou G, Spanakis N, Konstantinidou A, Piperaki ET, Kafetzis D, Patsouris E, et al. Detection of cytomegalovirus, parvovirus B19 and herpes simplex viruses in cases of intrauterine fetal death: association with pathological findings. J Med Virol. 2008; 80(10): 1776-82[DOI][PubMed]
  • 21. Weichert A, Vogt M, Dudenhausen JW, Kalache KD. Evidence in a human fetus of micrognathia and cleft lip as potential effects of early cytomegalovirus infection. Fetal Diagn Ther. 2010; 28(4): 225-8[DOI][PubMed]
  • 22. Ross SA, Ahmed A, Palmer AL, Michaels MG, Sanchez PJ, Bernstein DI, et al. Detection of congenital cytomegalovirus infection by real-time polymerase chain reaction analysis of saliva or urine specimens. J Infect Dis. 2014; 210(9): 1415-8[DOI][PubMed]
  • 23. Bialas KM, Swamy GK, Permar SR. Perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment. Clin Perinatol. 2015; 42(1): 61-75[DOI][PubMed]
  • 24. Szenborn L. [Significance of diagnostics and treatment in preventing congenital infections with Toxoplasma gondii (Tg), cytomegalovirus (CMV) and parvowirus B19 (PVB19)]. Przegl Lek. 2010; 67(1): 54-7[PubMed]
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