Iranian Red Crescent Medical Journal

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The Effects of Combined Low-Dose Oral Contraceptives and Vitex Agnus on the Improvement of Clinical and Paraclinical Parameters of Polycystic Ovarian Syndrome: A Triple-Blind, Randomized, Controlled Clinical Trial

Mahnaz Shahnazi 1 , Azizeh Farshbaf Khalili 2 , Kobra Hamdi 3 and Parvaneh Ghahremaninasab 1 , *
Authors Information
1 Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Science, Tabriz, Iran
2 Physical Medicine and Rehabilitation Research Center, Faculty of Nursing and Midwifery, Tabriz University of Medical Science, Tabriz, Iran
3 Department of obstetrics anf Gynecology, Tabriz University of Medical Science, Tabriz, Iran
Article information
  • Iranian Red Crescent Medical Journal: December 01, 2016, 18 (12); e37510
  • Published Online: August 6, 2016
  • Article Type: Research Article
  • Received: March 1, 2016
  • Revised: April 19, 2016
  • Accepted: May 1, 2016
  • DOI: 10.5812/ircmj.37510

To Cite: Shahnazi M, Farshbaf Khalili A, Hamdi K, Ghahremaninasab P. The Effects of Combined Low-Dose Oral Contraceptives and Vitex Agnus on the Improvement of Clinical and Paraclinical Parameters of Polycystic Ovarian Syndrome: A Triple-Blind, Randomized, Controlled Clinical Trial, Iran Red Crescent Med J. 2016 ; 18(12):e37510. doi: 10.5812/ircmj.37510.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Barbieri RL, Ehrmann DA. Clinical manifestations of polycystic ovary syndrome in adults. 2013;
  • 2. Speroff L, Fritz M. Clinical gynecologic endocrinology and infertility. 2012; : 521-8
  • 3. Elsheikh M, Murphy C. Polycystic Ovary Syndrome. 2008; : 3
  • 4. Azziz R. Epidemiology and pathogenesis of the polycystic ovary syndrome in adults. 2013;
  • 5. Boyle J, Teede HJ. Polycystic ovary syndrome - an update. Aust Fam Physician. 2012; 41(10): 752-6[PubMed]
  • 6. Moatasim A, Haque AU. Polycystic Ovarian Disease. Int J Pathol. 2006; 4(1): 1
  • 7. Long-term consequences of polycystic ovary syndrome. 2007;
  • 8. Sheehan MT. Polycystic ovarian syndrome: diagnosis and management. Clin Med Res. 2004; 2(1): 13-27[PubMed]
  • 9. Vrbikova J, Cibula D. Combined oral contraceptives in the treatment of polycystic ovary syndrome. Hum Reprod Update. 2005; 11(3): 277-91[DOI][PubMed]
  • 10. Family planning: a global handbook for providers. 2011;
  • 11. Roemheld-Hamm B. Chasteberry. Am Fam Physician. 2005; 72(5): 821-4[PubMed]
  • 12. Vitex and PCOS (Polycystic Ovary Syndrome). 2013;
  • 13. Herbs for PCOS: biphasic support for the menstrual cycle: The Natural Fertility Company. 2012;
  • 14. Herbal remedies and PCOS. 2013;
  • 15. Wuttke W, Jarry H, Christoffel V, Spengler B, Seidlova-Wuttke D. Chaste tree (Vitex agnus-castus)-pharmacology and clinical indications. Phytomedicine. 2003; 10(4): 348-57[DOI][PubMed]
  • 16. Ghosh VK, Nagore DH, Kadbhane KP, Patil MJ. Different approaches of alternative medicines in acne vulgaris treatment. Orient Pharm Exp Med. 2011; 11(1): 1-9[DOI]
  • 17. Increasing fertility with Vitex Agnus Castus herbs for helping you become pregnant. 2013;
  • 18. Ostrzenski A. Gynecology: Integrating Conventional, Complementary, and Natural Alternative Therapy. 2002; : 467
  • 19. Hywood A. Phytotherapy for polycystic ovarian syndrome. Australian J Herb Med. 2012; 24(3): 81
  • 20. Sekhavat L, Zaretazarjani F, Kolasehzadeh P. The effect of vitex agnus-castus on mastalgia in women. Iranian South Med J. 2009; 11(2): 147-52
  • 21. Shobeiri F, Zeraati F, Mansouri Z, Araghchian M, Nazari M. The comparative effect of herbal extract of Vitagnus and Mefenamic Acid on primary dysmenorrhea. Zahedan J Res Med Sci. 2012; 14(5): 30-3
  • 22. Abbaspour Z, Hajikhani N, Afshari P. Effect of Vitex Agnus Castus on early menopausal symptoms in postmenopausal women. J Sabzevar Univ Med Sci. 2005; 12(2): 26-30
  • 23. Kazemian A, Bromandfar K, Ghanadi A, Nourian K. Effect of Vitagnus and passi-pay on hot flash of menopausal women. Shahrekord Univ Med Sci J. 2005; 7(1): 35-49
  • 24. Taghizadeh Z, Rezaipour A, Kazemnejad A, Mirsaeedi Z. The study of the effect of vitex agnus-castus on the early menopausal complications in menopaused women. Hayat J. 2006; 12(1): 67-76
  • 25. Zamani M, Mansour GM, Farimani M, Nasrelahi S. . Efficacy of mefenamic acid and vitex in reduction of menstrual blood loss and HB changes in patients with a complaint of menorrhagia. Iranian J Obstetrics, Gyneocol Infertil. 2007; 10(1): 79-86
  • 26. Daniele C, Thompson Coon J, Pittler MH, Ernst E. Vitex agnus castus: a systematic review of adverse events. Drug Saf. 2005; 28(4): 319-32[PubMed]
  • 27. Women: a special case? 2013;
  • 28. Moghetti P, Castello R, Negri C, Tosi F, Perrone F, Caputo M, et al. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J Clin Endocrinol Metab. 2000; 85(1): 139-46[DOI][PubMed]
  • 29. Banaszewska B, Pawelczyk L, Spaczynski RZ, Dziura J, Duleba AJ. Effects of simvastatin and oral contraceptive agent on polycystic ovary syndrome: prospective, randomized, crossover trial. J Clin Endocrinol Metab. 2007; 92(2): 456-61[DOI][PubMed]
  • 30. Falsetti L, Gambera A, Tisi G. Efficacy of the combination ethinyl oestradiol and cyproterone acetate on endocrine, clinical and ultrasonographic profile in polycystic ovarian syndrome. Hum Reprod. 2001; 16(1): 36-42[PubMed]
  • 31. Bergmann J, Luft B, Boehmann S, Runnebaum B, Gerhard I. The efficacy of the complex medication Phyto-Hypophyson L in female, hormone-related sterility. A randomized, placebo-controlled clinical double-blind study [in German]. Forsch Komplementarmed Klass Naturheilkd. 2000; 7(4): 190-9[PubMed]
  • 32. Westphal LM, Polan ML, Trant AS. Double-blind, placebo-controlled study of Fertilityblend: a nutritional supplement for improving fertility in women. Clin Exp Obstet Gynecol. 2006; 33(4): 205-8[PubMed]
  • 33. Böhnert KJ. The use of Vitex agnus castus for hyperprolactinemia. Quart Rev Nat Med. 1997; : 19-21
  • 34. Propping D, Bohnert KJ, Peeters M. Vitex agnus-castus treatment of gynecological syndromes. Therapeutikon. 1991; 5(11): 581-5
  • 35. Jelodar G, Askari K. Effect of Vitex agnus-castus fruits hydroalcoholic extract on sex hormones in rat with induced polycystic ovary syndrome (PCOS). Physiol Pharmacol. 2012; 16(1): 62-9
  • 36. Hoeger K, Davidson K, Kochman L, Cherry T, Kopin L, Guzick DS. The impact of metformin, oral contraceptives, and lifestyle modification on polycystic ovary syndrome in obese adolescent women in two randomized, placebo-controlled clinical trials. J Clin Endocrinol Metab. 2008; 93(11): 4299-306[DOI][PubMed]
  • 37. Nasri S, Oryan S, Haeri Rohani A, Amin G, Yahyavi H. The effects of vitex agnus castus L. extract on gonadotrophines and testosterone in male mice. Iranian Int J Sci. 2004; 5(1): 25-31
  • 38. Webster DE, Lu J, Chen SN, Farnsworth NR, Wang ZJ. Activation of the mu-opiate receptor by Vitex agnus-castus methanol extracts: implication for its use in PMS. J Ethnopharmacol. 2006; 106(2): 216-21[DOI][PubMed]
  • 39. Malaivijitnond S, Kiatthaipipat P, Cherdshewasart W, Watanabe G, Taya K. Different effects of Pueraria mirifica, a herb containing phytoestrogens, on LH and FSH secretion in gonadectomized female and male rats. J Pharmacol Sci. 2004; 96(4): 428-35[PubMed]
  • 40. Milewicz A, Gejdel E, Sworen H, Sienkiewicz K, Jedrzejak J, Teucher T, et al. Vitex agnus castus extract in the treatment of luteal phase defects due to latent hyperprolactinemia. Results of a randomized placebo-controlled double-blind study [in German]. Arzneim Forsch. 1993; 43(7): 752-6
  • 41. Jarry H, Spengler B, Wuttke W, Christoffel V. In vitro assays for bioactivity-guided isolation of endocrine active compounds in Vitex agnus-castus. Maturitas. 2006; 55: 26-36[DOI]
  • 42. Sliutz G, Speiser P, Schultz AM, Spona J, Zeillinger R. Agnus castus extracts inhibit prolactin secretion of rat pituitary cells. Horm Metab Res. 1993; 25(5): 253-5[DOI][PubMed]
  • 43. Bush RA. Female high-school varsity athletics: an opportunity to improve bone mineral density. J Sci Med Sport. 2009; 12(3): 366-70[DOI][PubMed]
  • 44. Gibbs RS, Karlan BY, Haney AF, Nygaard IE. Danforth's obstetrics and gynecology. 2008;
  • 45. Zegeye DT, Megabiaw B, Mulu A. Age at menarche and the menstrual pattern of secondary school adolescents in northwest Ethiopia. BMC Womens Health. 2009; 9: 29[DOI][PubMed]
  • 46. De Souza MJ, Williams NI. Physiological aspects and clinical sequelae of energy deficiency and hypoestrogenism in exercising women. Hum Reprod Update. 2004; 10(5): 433-48[DOI][PubMed]
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