Iranian Red Crescent Medical Journal

Published by: Kowsar

Literature Review of Adipose-derived Mesanchymal Cells from History to Approaches

Mohammad Amir Amirkhani 1 , 2 , Sona Zare 1 , Alireza Shoaei-Hassani 3 , Elham Torbati 4 and Mohammad Ali Nilforoushzadeh 1 , *
Authors Information
1 Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
2 MOHME Faculty Member, Adviser of Curative Deputy, Tehran, IR Iran
3 Research Center for Science and Technology in Medicine RCSTM, Tehran University of Medical Sciences, Tehran, IR Iran
4 Young and Elite Research Club, Tehran, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: January 01, 2017, 19 (1); e22940
  • Published Online: August 3, 2016
  • Article Type: Review Article
  • Received: August 20, 2014
  • Revised: September 27, 2014
  • Accepted: May 30, 2016
  • DOI: 10.5812/ircmj.22940

To Cite: Amirkhani M A, Zare S, Shoaei-Hassani A, Torbati E, Nilforoushzadeh M A. Literature Review of Adipose-derived Mesanchymal Cells from History to Approaches, Iran Red Crescent Med J. 2017 ; 19(1):e22940. doi: 10.5812/ircmj.22940.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Becker AJ, Mc CE, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963; 197: 452-4[PubMed]
  • 2. Sabin FR, Doan CA, Forkner CE. The Production of Osteogenic Sarcomata and the Effects on Lymph Nodes and Bone Marrow of Intravenous Injections of Radium Chloride and Mesothorium in Rabbits. J Exp Med. 1932; 56(2): 267-89[PubMed]
  • 3. Ramalho-Santos M, Willenbring H. On the origin of the term "stem cell". Cell Stem Cell. 2007; 1(1): 35-8[DOI][PubMed]
  • 4. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981; 292(5819): 154-6[PubMed]
  • 5. Bianco P, Robey PG, Simmons PJ. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell. 2008; 2(4): 313-9[DOI][PubMed]
  • 6. Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970; 3(4): 393-403[PubMed]
  • 7. Fridenshtein A. [Osteogenic stem cells of the bone marrow]. Ontogenez. 1991; 22(2): 189-97[PubMed]
  • 8. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411): 143-7[PubMed]
  • 9. Caplan AI. Review: mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng. 2005; 11(7-8): 1198-211[DOI][PubMed]
  • 10. Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007; 213(2): 341-7[DOI][PubMed]
  • 11. Zuk PA. The adipose-derived stem cell: looking back and looking ahead. Mol Biol Cell. 2010; 21(11): 1783-7[DOI][PubMed]
  • 12. Safford KM, Safford SD, Gimble JM, Shetty AK, Rice HE. Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. Exp Neurol. 2004; 187(2): 319-28[DOI][PubMed]
  • 13. Trottier V, Marceau-Fortier G, Germain L, Vincent C, Fradette J. IFATS collection: Using human adipose-derived stem/stromal cells for the production of new skin substitutes. Stem Cells. 2008; 26(10): 2713-23[DOI][PubMed]
  • 14. Lendeckel S, Jodicke A, Christophis P, Heidinger K, Wolff J, Fraser JK, et al. Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report. J Craniomaxillofac Surg. 2004; 32(6): 370-3[DOI][PubMed]
  • 15. Gimble JM, Katz AJ, Bunnell BA. Adipose-derived stem cells for regenerative medicine. Circ Res. 2007; 100(9): 1249-60[DOI][PubMed]
  • 16. Pountos I, Giannoudis PV. Biology of mesenchymal stem cells. Injury. 2005; 36 Suppl 3[DOI][PubMed]
  • 17. Oni OO. Early histological and ultrastructural changes in medullary fracture callus. J Bone Joint Surg Am. 1992; 74(4): 633-4[PubMed]
  • 18. Antonitsis P, Ioannidou-Papagiannaki E, Kaidoglou A, Papakonstantinou C. In vitro cardiomyogenic differentiation of adult human bone marrow mesenchymal stem cells. The role of 5-azacytidine. Interact Cardiovasc Thorac Surg. 2007; 6(5): 593-7[DOI][PubMed]
  • 19. Schieker M, Pautke C, Haasters F, Schieker J, Docheva D, Bocker W, et al. Human mesenchymal stem cells at the single-cell level: simultaneous seven-colour immunofluorescence. J Anat. 2007; 210(5): 592-9[DOI][PubMed]
  • 20. Polak J, Mantalaris S, Harding SE. Advances in Tissue Engineering. 2008; [DOI]
  • 21. Orbay H, Tobita M, Mizuno H. Mesenchymal stem cells isolated from adipose and other tissues: Basic biological properties and clinical applications. Stem Cells Int. 2012; 2012
  • 22. Gnecchi M, Melo LG. Bone marrow-derived mesenchymal stem cells: isolation, expansion, characterization, viral transduction, and production of conditioned medium. Methods Mol Biol. 2009; 482: 281-94[DOI][PubMed]
  • 23. Kassis I, Zangi L, Rivkin R, Levdansky L, Samuel S, Marx G, et al. Isolation of mesenchymal stem cells from G-CSF-mobilized human peripheral blood using fibrin microbeads. Bone Marrow Transplant. 2006; 37(10): 967-76[DOI][PubMed]
  • 24. Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006; 8(4): 315-7[DOI][PubMed]
  • 25. Roubelakis MG, Tsaknakis G, Pappa KI, Anagnou NP, Watt SM. Spindle shaped human mesenchymal stem/stromal cells from amniotic fluid promote neovascularization. PLoS One. 2013; 8(1): 54747[DOI][PubMed]
  • 26. Verdi J, Tan A, Shoae-Hassani A, Seifalian AM. Endometrial stem cells in regenerative medicine. J Biol Eng. 2014; 8: 20[DOI][PubMed]
  • 27. Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol. 2004; 36(4): 568-84[DOI][PubMed]
  • 28. Klingemann H, Matzilevich D, Marchand J. Mesenchymal Stem Cells - Sources and Clinical Applications. Transfus Med Hemother. 2008; 35(4): 272-7[DOI][PubMed]
  • 29. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7(2): 211-28[DOI][PubMed]
  • 30. Lu F, Mizuno H, Uysal CA, Cai X, Ogawa R, Hyakusoku H. Improved viability of random pattern skin flaps through the use of adipose-derived stem cells. Plast Reconstr Surg. 2008; 121(1): 50-8[DOI][PubMed]
  • 31. Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci. 2007; 48(1): 15-24[DOI][PubMed]
  • 32. Sterodimas A, de Faria J, Nicaretta B, Pitanguy I. Tissue engineering with adipose-derived stem cells (ADSCs): current and future applications. J Plast Reconstr Aesthet Surg. 2010; 63(11): 1886-92[DOI][PubMed]
  • 33. Kim WS, Park BS, Park SH, Kim HK, Sung JH. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009; 53(2): 96-102[DOI][PubMed]
  • 34. Jeong JH. Adipose stem cells and skin repair. Curr Stem Cell Res Ther. 2010; 5(2): 137-40[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments