Iranian Red Crescent Medical Journal

Published by: Kowsar

Mesenchymal Stem Cells Improve Ischemic Stroke Injury by Anti-Inflammatory Properties in Rat Model of Middle Cerebral Artery Occlusion

Majid Nejati 1 , Abolfazl Azami Tameh 1 , Zeinab Vahidinia 1 and Mohammad Ali Atlasi 1 , *
Authors Information
1 Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: January 2018, 20 (1); e55085
  • Published Online: January 10, 2018
  • Article Type: Research Article
  • Received: June 16, 2017
  • Revised: August 10, 2017
  • Accepted: November 1, 2017
  • DOI: 10.5812/ircmj.55085

To Cite: Nejati M, Azami Tameh A, Vahidinia Z, Atlasi M A. Mesenchymal Stem Cells Improve Ischemic Stroke Injury by Anti-Inflammatory Properties in Rat Model of Middle Cerebral Artery Occlusion, Iran Red Crescent Med J. 2018 ; 20(1):e55085. doi: 10.5812/ircmj.55085.

Abstract
Copyright © 2018, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnote
References
  • 1. Heo JS, Choi SM, Kim HO, Kim EH, You J, Park T, et al. Neural transdifferentiation of human bone marrow mesenchymal stem cells on hydrophobic polymer-modified surface and therapeutic effects in an animal model of ischemic stroke. Neuroscience. 2013;238:305-18. doi: 10.1016/j.neuroscience.2013.02.011. [PubMed: 23454369].
  • 2. Steiner B, Roch M, Holtkamp N, Kurtz A. Systemically administered human bone marrow-derived mesenchymal stem home into peripheral organs but do not induce neuroprotective effects in the MCAo-mouse model for cerebral ischemia. Neurosci Lett. 2012;513(1):25-30. doi: 10.1016/j.neulet.2012.01.078. [PubMed: 22342911].
  • 3. Denker SP, Ji S, Dingman A, Lee SY, Derugin N, Wendland MF, et al. Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke. J Neurochem. 2007;100(4):893-904. doi: 10.1111/j.1471-4159.2006.04162.x. [PubMed: 17212701].
  • 4. Schilling M, Besselmann M, Leonhard C, Mueller M, Ringelstein EB, Kiefer R. Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice. Exp Neurol. 2003;183(1):25-33. [PubMed: 12957485].
  • 5. Yilmaz A, Fuchs T, Dietel B, Altendorf R, Cicha I, Stumpf C, et al. Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain. Clin Sci (Lond). 2009;118(2):147-57. doi: 10.1042/CS20090154. [PubMed: 19508233].
  • 6. Jin R, Yang G, Li G. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol. 2010;87(5):779-89. doi: 10.1189/jlb.1109766. [PubMed: 20130219].
  • 7. Hu X, Li P, Guo Y, Wang H, Leak RK, Chen S, et al. Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke. 2012;43(11):3063-70. doi: 10.1161/STROKEAHA.112.659656. [PubMed: 22933588].
  • 8. Emsley HC, Tyrrell PJ. Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab. 2002;22(12):1399-419. doi: 10.1097/01.WCB.0000037880.62590.28. [PubMed: 12468886].
  • 9. Liu YP, Seckin H, Izci Y, Du ZW, Yan YP, Baskaya MK. Neuroprotective effects of mesenchymal stem cells derived from human embryonic stem cells in transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2009;29(4):780-91. doi: 10.1038/jcbfm.2009.1. [PubMed: 19209181].
  • 10. Prockop DJ, Oh JY. Mesenchymal stem/stromal cells (MSCs): role as guardians of inflammation. Mol Ther. 2012;20(1):14-20. doi: 10.1038/mt.2011.211. [PubMed: 22008910].
  • 11. Nejad Moghaddam A, Ajdari S, Tahmasbpour E, Goodarzi H, Panahi Y, Ghanei M. Adipose derived mesenchymal stem cells for treatment of airway injuries in a patient after long term exposure to sulfur mustard. Cell J. 2017;19(1):117-26. [PubMed: 28367422].
  • 12. Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, et al. Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Mol Ther. 2010;18(10):1857-64. doi: 10.1038/mt.2010.155. [PubMed: 20664529].
  • 13. Asari S, Itakura S, Ferreri K, Liu CP, Kuroda Y, Kandeel F, et al. Mesenchymal stem cells suppress B-cell terminal differentiation. Exp Hematol. 2009;37(5):604-15. doi: 10.1016/j.exphem.2009.01.005. [PubMed: 19375651].
  • 14. Giuliani M, Fleury M, Vernochet A, Ketroussi F, Clay D, Azzarone B, et al. Long lasting inhibitory effects of fetal liver mesenchymal stem cells on T-lymphocyte proliferation. PLoS One. 2011;6(5):19988. doi: 10.1371/journal.pone.0019988. [PubMed: 21625521].
  • 15. Dulamea AO. The potential use of mesenchymal stem cells in stroke therapy--From bench to bedside. J Neurol Sci. 2015;352(1-2):1-11. doi: 10.1016/j.jns.2015.03.014. [PubMed: 25818674].
  • 16. Chu X, Qi C, Zou L, Fu X. Intraluminal suture occlusion and ligation of the distal branch of internal carotid artery: an improved rat model of focal cerebral ischemia-reperfusion. J Neurosci Methods. 2008;168(1):1-7. doi: 10.1016/j.jneumeth.2007.08.030. [PubMed: 18029024].
  • 17. Vahidinia Z, Alipour N, Atlasi MA, Naderian H, Beyer C, Azami Tameh A. Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model. Neurol Res. 2017;39(1):54-64. doi: 10.1080/01616412.2016.1250459. [PubMed: 27832728].
  • 18. Garcia JH, Wagner S, Liu KF, Hu XJ. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995;26(4):627-34. [PubMed: 7709410].
  • 19. Overbergh L, Giulietti A, Valckx D, Decallonne R, Bouillon R, Mathieu C. The use of real-time reverse transcriptase PCR for the quantification of cytokine gene expression. J Biomol Tech. 2003;14(1):33-43. [PubMed: 12901609].
  • 20. Bayati V, Hashemitabar M, Gazor R, Nejatbakhsh R, Bijannejad D. Expression of surface markers and myogenic potential of rat bone marrow- and adipose-derived stem cells: a comparative study. Anat Cell Biol. 2013;46(2):113-21. doi: 10.5115/acb.2013.46.2.113. [PubMed: 23869258].
  • 21. Boxall SA, Jones E. Markers for characterization of bone marrow multipotential stromal cells. Stem Cells Int. 2012;2012:1-12. doi: 10.1155/2012/975871.
  • 22. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101-8. [PubMed: 18546601].
  • 23. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool, (REST) for group-wise comparison and statistical analysis of relative expression results in real time PCR. Nucleic Acids Res. 2002;30(9):36. [PubMed: 11972351].
  • 24. Toyoshima A, Yasuhara T, Kameda M, Morimoto J, Takeuchi H, Wang F, et al. Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms. PLoS One. 2015;10(6):127302. doi: 10.1371/journal.pone.0127302. [PubMed: 26075717].
  • 25. Nejad-Moghaddam A, Panahi Y, Abdollahpour Alitappeh M, Borna H, Shokrgozar MA, Ghanei M. Therapeutic Potential of Mesenchymal Stem Cells for the Treatment of Airway Remodeling in Pulmonary Diseases. Iran J Allergy Asthma Immunol. 2015;14(6):552-68. [PubMed: 26725553].
  • 26. Weil BR, Manukyan MC, Herrmann JL, Abarbanell AM, Poynter JA, Wang Y, et al. The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease. J Surg Res. 2011;167(1):78-86. doi: 10.1016/j.jss.2010.07.019. [PubMed: 20869073].
  • 27. English K. Mechanisms of mesenchymal stromal cell immunomodulation. Immunol Cell Biol. 2013;91(1):19-26. doi: 10.1038/icb.2012.56. [PubMed: 23090487].
  • 28. Gebler A, Zabel O, Seliger B. The immunomodulatory capacity of mesenchymal stem cells. Trends Mol Med. 2012;18(2):128-34. doi: 10.1016/j.molmed.2011.10.004. [PubMed: 22118960].
  • 29. Selmani Z, Naji A, Gaiffe E, Obert L, Tiberghien P, Rouas Freiss N, et al. HLA G is a crucial immunosuppressive molecule secreted by adult human mesenchymal stem cells. Transplantation. 2009;87(9 Suppl):62-6. doi: 10.1097/TP.0b013e3181a2a4b3. [PubMed: 19424010].
  • 30. Rafei M, Hsieh J, Fortier S, Li M, Yuan S, Birman E, et al. Mesenchymal stromal cell-derived CCL2 suppresses plasma cell immunoglobulin production via STAT3 inactivation and PAX5 induction. Blood. 2008;112(13):4991-8. doi: 10.1182/blood-2008-07-166892. [PubMed: 18812467].
  • 31. Nasef A, Mazurier C, Bouchet S, Francois S, Chapel A, Thierry D, et al. Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression. Cell Immunol. 2008;253(1-2):16-22. doi: 10.1016/j.cellimm.2008.06.002. [PubMed: 18639869].
  • 32. Volarevic V, Al-Qahtani A, Arsenijevic N, Pajovic S, Lukic ML. Interleukin-1 receptor antagonist (IL-1Ra) and IL-1Ra producing mesenchymal stem cells as modulators of diabetogenesis. Autoimmunity. 2010;43(4):255-63. doi: 10.3109/08916930903305641. [PubMed: 19845478].
  • 33. Ding Y, Xu D, Feng G, Bushell A, Muschel RJ, Wood KJ. Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. Diabetes. 2009;58(8):1797-806. doi: 10.2337/db09-0317. [PubMed: 19509016].
  • 34. Bunnell BA, Betancourt AM, Sullivan DE. New concepts on the immune modulation mediated by mesenchymal stem cells. Stem Cell Res Ther. 2010;1(5):34. doi: 10.1186/scrt34. [PubMed: 21092149].
  • 35. Kokai LE, Rubin JP, Marra KG. The potential of adipose-derived adult stem cells as a source of neuronal progenitor cells. Plast Reconstr Surg. 2005;116(5):1453-60. [PubMed: 16217495].
  • 36. Zhang R, Liu Y, Yan K, Chen L, Chen XR, Li P, et al. Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury. J Neuroinflammation. 2013;10:106. doi: 10.1186/1742-2094-10-106. [PubMed: 23971414].
  • 37. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood. 2004;103(12):4619-21. doi: 10.1182/blood-2003-11-3909. [PubMed: 15001472].
  • 38. Scuteri A, Miloso M, Foudah D, Orciani M, Cavaletti G, Tredici G. Mesenchymal stem cells neuronal differentiation ability: a real perspective for nervous system repair?. Curr Stem Cell Res Ther. 2011;6(2):82-92. [PubMed: 21190538].
  • 39. Downes CE, Crack PJ. Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?. Br J Pharmacol. 2010;160(8):1872-88. doi: 10.1111/j.1476-5381.2010.00864.x. [PubMed: 20649586].
  • 40. Yoo KH, Jang IK, Lee MW, Kim HE, Yang MS, Eom Y, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cell Immunol. 2009;259(2):150-6. doi: 10.1016/j.cellimm.2009.06.010. [PubMed: 19608159].
  • 41. Bao X, Wei J, Feng M, Lu S, Li G, Dou W, et al. Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats. Brain Res. 2011;1367:103-13. doi: 10.1016/j.brainres.2010.10.063. [PubMed: 20977892].
  • 42. Ke Z, Yip SP, Li L, Zheng XX, Tam WK, Tong KY. The effects of voluntary, involuntary, and forced exercises on motor recovery in a stroke rat model. Annual International Conference of the IEEE. Boston, MA, USA. Engineering in Medicine and Biology Society, EMBC; 2011.
  • 43. Yano S, Kuroda S, Shichinohe H, Hida K, Iwasaki Y. Do bone marrow stromal cells proliferate after transplantation into mice cerebral infarct? a double labeling study. Brain Res. 2005;1065(1-2):60-7. doi: 10.1016/j.brainres.2005.10.031. [PubMed: 16313889].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments