Iranian Red Crescent Medical Journal

Published by: Kowsar

The Effect of Ondansetron on Decreasing the Hospitalization Rate in Children with Gastroenteritis and Recurrent Vomiting

Manoochehr Mahram 1 , Maryam Darabi 2 and Sonia Oveisi 3 , *
Authors Information
1 Professor of Pediatrics, Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
2 Resident of Pediatrics, Children Growth Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
3 Associate Professor of Maternity and Child Health, Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Article information
  • Iranian Red Crescent Medical Journal: November 01, 2016, 18 (11); e42907
  • Published Online: October 18, 2016
  • Article Type: Research Article
  • Received: October 9, 2016
  • Accepted: October 10, 2016
  • DOI: 10.5812/ircmj.42907

To Cite: Mahram M, Darabi M, Oveisi S. The Effect of Ondansetron on Decreasing the Hospitalization Rate in Children with Gastroenteritis and Recurrent Vomiting, Iran Red Crescent Med J. 2016 ; 18(11):e42907. doi: 10.5812/ircmj.42907.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Methods
3. Results
4. Interpretation
  • 1. Kliegman R, Stanton B, St Geme J, Schor N, Behrman R. Nelson Textbook of Pediatrics. 2011;
  • 2. Sturm JJ, Hirsh DA, Schweickert A, Massey R, Simon HK. Ondansetron use in the pediatric emergency department and effects on hospitalization and return rates: are we masking alternative diagnoses? Ann Emerg Med. 2010; 55(5): 415-22[DOI][PubMed]
  • 3. Matlow AG, Baker GR, Flintoft V, Cochrane D, Coffey M, Cohen E, et al. Adverse events among children in Canadian hospitals: the Canadian Paediatric Adverse Events Study. CMAJ. 2012; 184(13): 709-18[DOI][PubMed]
  • 4. Freedman SB, Steiner MJ, Chan KJ. Oral ondansetron administration in emergency departments to children with gastroenteritis: an economic analysis. PLoS Med. 2010; 7(10)[DOI][PubMed]
  • 5. Cheng A. Emergency department use of oral ondansetron for acute gastroenteritis-related vomiting in infants and children. Paediatr Child Health. 2011; 16(3): 177-82[PubMed]
  • 6. Pfeil N, Uhlig U, Kostev K, Carius R, Schroder H, Kiess W, et al. Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America. J Pediatr. 2008; 153(5): 659-62[DOI][PubMed]
  • 7. Fedorowicz Z, Jagannath VA, Carter B. Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. Cochrane Database Syst Rev. 2011; (9)[DOI][PubMed]
  • 8. Setayesh A, Ghahramani F, Hosseini Teshnize S. Role of ondansetron in decreasing vomiting and duration of hospitalization in children aged 6 months to 14 years. Electronic Physician. 2010; : 95-101
  • 9. Szajewska H, Gieruszczak-Bialek D, Dylag M. Meta-analysis: ondansetron for vomiting in acute gastroenteritis in children. Aliment Pharmacol Ther. 2007; 25(4): 393-400[DOI][PubMed]
  • 10. Reeves JJ, Shannon MW, Fleisher GR. Ondansetron decreases vomiting associated with acute gastroenteritis: a randomized, controlled trial. Pediatrics. 2002; 109(4): 62[PubMed]
  • 11. Golshekan K, Badeli H, Rezaieian S, Mohammadpour H, Hassanzadehrad A. Effect of oral ondansetron on decreasing the vomiting associated with acute gastroenteritis in Iranian children. Iran J Pediatr. 2013; 23(5): 557-63[PubMed]
  • 12. Roslund G, Hepps TS, McQuillen KK. The role of oral ondansetron in children with vomiting as a result of acute gastritis/gastroenteritis who have failed oral rehydration therapy: a randomized controlled trial. Ann Emerg Med. 2008; 52(1): 22-9[DOI][PubMed]
  • 13. Al-Ansari K, Alomary S, Abdulateef H, Alshawagfa M, Kamal K. Metoclopramide versus ondansetron for the treatment of vomiting in children with acute gastroenteritis. J Pediatr Gastroenterol Nutr. 2011; 53(2): 156-60[DOI][PubMed]
  • 14. Das JK, Kumar R, Salam RA, Freedman S, Bhutta ZA. The effect of antiemetics in childhood gastroenteritis. BMC Public Health. 2013; 13 Suppl 3[DOI][PubMed]
  • 15. Tabbah MJ. P0560 Cost-Effectiveness of Ondansetron Treatment in Vomiting Associated with Acute Gastroenteritis in Children. J Ped Gastroentero Nut. 2004; 39-70[DOI]
  • 16. Freedman SB, Adler M, Seshadri R, Powell EC. Oral ondansetron for gastroenteritis in a pediatric emergency department. N Engl J Med. 2006; 354(16): 1698-705[DOI][PubMed]
  • 17. DeCamp LR, Byerley JS, Doshi N, Steiner MJ. Use of antiemetic agents in acute gastroenteritis: a systematic review and meta-analysis. Arch Pediatr Adolesc Med. 2008; 162(9): 858-65[DOI][PubMed]
  • 18. Gavagan T, Schumann SA. This antiemetic may help kids skip that trip to the hospital. J Fam Pract. 2009; 58(2): 85-8[PubMed]
  • 19. Mullarkey C, Crowley E, Martin C. The addition of ondansetron to a oral rehydration protocol for children with acute gastroenteritis. Ir Med J. 2013; 106(9): 266-8[PubMed]
  • 20. Rerksuppaphol S, Rerksuppaphol L. Efficacy of intravenous ondansetron to prevent vomiting episodes in acute gastroenteritis: a randomized, double blind, and controlled trial. Pediatr Rep. 2010; 2(2): 17[DOI][PubMed]
  • 21. Yilmaz HL, Yildizdas RD, Sertdemir Y. Clinical trial: oral ondansetron for reducing vomiting secondary to acute gastroenteritis in children – a double-blind randomized study. Aliment Pharmacol Therap. 2010; 31(1): 82-91[DOI]
  • 22. Advice. Management of vomiting in children and young people with gastroenteritis: ondansetron. 2014;
  • 23. Sturm JJ, Pierzchala A, Simon HK, Hirsh DA. Ondansetron use in the pediatric emergency room for diagnoses other than acute gastroenteritis. Pediatr Emerg Care. 2012; 28(3): 247-50[DOI][PubMed]
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