Iranian Red Crescent Medical Journal

Published by: Kowsar

Fluid Resuscitation, Which Fluid is the Best for Each Patient? A Systematic Review and Meta Analysis

Seyed Mohammad Heshmati 1 , Ali Ebrahimi 1 , * and Hamid Reza Rasouli 1
Authors Information
1 Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Article information
  • Iranian Red Crescent Medical Journal: March 01, 2017, 19 (3); e41729
  • Published Online: December 31, 2016
  • Article Type: Review Article
  • Received: August 23, 2016
  • Revised: October 15, 2016
  • Accepted: December 7, 2016
  • DOI: 10.5812/ircmj.41729

To Cite: Heshmati S M, Ebrahimi A, Rasouli H R. Fluid Resuscitation, Which Fluid is the Best for Each Patient? A Systematic Review and Meta Analysis, Iran Red Crescent Med J. 2017 ; 19(3):e41729. doi: 10.5812/ircmj.41729.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Methods
3. Results
4. Discussion
  • 1. Armstrong RF, Bullen C, Cohen SL, Singer M, Webb AR. Critical care algorithms. 1991;
  • 2. Vermeulen LC Jr, Ratko TA, Erstad BL, Brecher ME, Matuszewski KA. A paradigm for consensus. The University Hospital Consortium guidelines for the use of albumin, nonprotein colloid, and crystalloid solutions. Arch Intern Med. 1995; 155(4): 373-9[PubMed]
  • 3. Assmann SF, Pocock SJ, Enos LE, Kasten LE. Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet. 2000; 355(9209): 1064-9[DOI][PubMed]
  • 4. Delaney AP, Dan A, McCaffrey J, Finfer S. The role of albumin as a resuscitation fluid for patients with sepsis: a systematic review and meta-analysis. Crit Care Med. 2011; 39(2): 386-91[DOI][PubMed]
  • 5. Jiang L, Jiang S, Zhang M, Zheng Z, Ma Y. Albumin versus other fluids for fluid resuscitation in patients with sepsis: a meta-analysis. PLoS One. 2014; 9(12)[DOI][PubMed]
  • 6. Qureshi SH, Rizvi SI, Patel NN, Murphy GJ. Meta-analysis of colloids versus crystalloids in critically ill, trauma and surgical patients. Br J Surg. 2016; 103(1): 14-26[DOI][PubMed]
  • 7. Uhlig C, Silva PL, Deckert S, Schmitt J, de Abreu MG. Albumin versus crystalloid solutions in patients with the acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care. 2014; 18(1)[DOI][PubMed]
  • 8. Xu JY, Chen QH, Xie JF, Pan C, Liu SQ, Huang LW, et al. Comparison of the effects of albumin and crystalloid on mortality in adult patients with severe sepsis and septic shock: a meta-analysis of randomized clinical trials. Crit Care. 2014; 18(6): 702[DOI][PubMed]
  • 9. Zarychanski R, Abou-Setta AM, Turgeon AF, Houston BL, McIntyre L, Marshall JC, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA. 2013; 309(7): 678-88[DOI][PubMed]
  • 10. Gattas DJ, Dan A, Myburgh J, Billot L, Lo S, Finfer S, et al. Fluid resuscitation with 6 % hydroxyethyl starch (130/0.4 and 130/0.42) in acutely ill patients: systematic review of effects on mortality and treatment with renal replacement therapy. Intensive Care Med. 2013; 39(4): 558-68[DOI][PubMed]
  • 11. Raiman M, Mitchell CG, Biccard BM, Rodseth RN. Comparison of hydroxyethyl starch colloids with crystalloids for surgical patients: A systematic review and meta-analysis. Eur J Anaesthesiol. 2016; 33(1): 42-8[DOI][PubMed]
  • 12. Schierhout G, Roberts I. Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. BMJ. 1998; 316(7136): 961-4[PubMed]
  • 13. Moher D, Liberati A, Tetzlaff J, Altman DG, Prisma Group . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010; 8(5): 336-41[DOI][PubMed]
  • 14. Alpar EK, Killampalli VV. Effects of hypertonic dextran in hypovolaemic shock: a prospective clinical trial. Injury. 2004; 35(5): 500-6[DOI]
  • 15. Webb AR. Crystalloid or colloid for resuscitation. Are we any the wiser? Crit Care. 1999; 3(3)-8[DOI][PubMed]
  • 16. Bechir M, Puhan MA, Fasshauer M, Schuepbach RA, Stocker R, Neff TA. Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial. Crit Care. 2013; 17(6)[DOI][PubMed]
  • 17. Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008; 358(2): 125-39[DOI][PubMed]
  • 18. Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014; 370(15): 1412-21[DOI][PubMed]
  • 19. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013; 41(2): 580-637[DOI][PubMed]
  • 20. Dubin A, Pozo MO, Casabella CA, Murias G, Palizas F Jr, Moseinco MC, et al. Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients. J Crit Care. 2010; 25(4): 659 e1-8[DOI][PubMed]
  • 21. Feldheiser A, Pavlova V, Bonomo T, Jones A, Fotopoulou C, Sehouli J, et al. Balanced crystalloid compared with balanced colloid solution using a goal-directed haemodynamic algorithm. Br J Anaesth. 2013; 110(2): 231-40[DOI][PubMed]
  • 22. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004; 350(22): 2247-56[DOI][PubMed]
  • 23. Guidet B, Martinet O, Boulain T, Philippart F, Poussel JF, Maizel J, et al. Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: the CRYSTMAS study. Crit Care. 2012; 16(3)[DOI][PubMed]
  • 24. Guidry C, Gleeson E, Simms ER, Stuke L, Meade P, McSwain NE Jr, et al. Initial assessment on the impact of crystalloids versus colloids during damage control resuscitation. J Surg Res. 2013; 185(1): 294-9[DOI][PubMed]
  • 25. Harten J, Crozier JE, McCreath B, Hay A, McMillan DC, McArdle CS, et al. Effect of intraoperative fluid optimisation on renal function in patients undergoing emergency abdominal surgery: a randomised controlled pilot study (ISRCTN 11799696). Int J Surg. 2008; 6(3): 197-204[DOI][PubMed]
  • 26. Lowe RJ, Moss GS, Jilek J, Levine HD. Crystalloid vs colloid in the etiology of pulmonary failure after trauma: a randomized trial in man. Surgery. 1977; 81(6): 676-83[PubMed]
  • 27. Lucas CE, Weaver D, Higgins RF, Ledgerwood AM, Johnson SD, Bouwman DL. Effects of albumin versus non-albumin resuscitation on plasma volume and renal excretory function. J Trauma. 1978; 18(8): 564-70[PubMed]
  • 28. Mattox KL, Maningas PA, Moore EE, Mateer JR, Marx JA, Aprahamian C, et al. Prehospital hypertonic saline/dextran infusion for post-traumatic hypotension. The U.S.A. Multicenter Trial. Ann Surg. 1991; 213(5): 482-91[PubMed]
  • 29. McIntyre LA, Fergusson D, Cook DJ, Rankin N, Dhingra V, Granton J, et al. Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial. Can J Anaesth. 2008; 55(12): 819-26[DOI][PubMed]
  • 30. Metildi LA, Shackford SR, Virgilio RW, Peters RM. Crystalloid versus colloid in fluid resuscitation of patients with severe pulmonary insufficiency. Surg Gynecol Obstet. 1984; 158(3): 207-12[PubMed]
  • 31. Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012; 367(20): 1901-11[DOI][PubMed]
  • 32. Oliveira RP, Velasco I, Soriano FG, Friedman G. Clinical review: Hypertonic saline resuscitation in sepsis. Crit Care. 2002; 6(5): 418-23[PubMed]
  • 33. Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev. 2013; (2)[DOI][PubMed]
  • 34. Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, Aneman A, et al. Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med. 2012; 367(2): 124-34[DOI][PubMed]
  • 35. Rackow EC, Falk JL, Fein IA, Siegel JS, Packman MI, Haupt MT, et al. Fluid resuscitation in circulatory shock: a comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock. Crit Care Med. 1983; 11(11): 839-50[PubMed]
  • 36. Shah DM, Browner BD, Dutton RE, Newell JC, Powers SR Jr. Cardiac output and pulmonary wedge pressure. Use for evaluation of fluid replacement in trauma patients. Arch Surg. 1977; 112(10): 1161-8[PubMed]
  • 37. Tollofsrud S, Tonnessen T, Skraastad O, Noddeland H. Hypertonic saline and dextran in normovolaemic and hypovolaemic healthy volunteers increases interstitial and intravascular fluid volumes. Acta Anaesthesiol Scand. 1998; 42(2): 145-53[PubMed]
  • 38. van der Heijden M, Verheij J, van Nieuw Amerongen GP, Groeneveld AB. Crystalloid or colloid fluid loading and pulmonary permeability, edema, and injury in septic and nonseptic critically ill patients with hypovolemia. Crit Care Med. 2009; 37(4): 1275-81[DOI][PubMed]
  • 39. Wu J, Zhu Y, Pullum L. The effect of impeller pumping and fluid rheology on solids suspension in a stirred vessel. Can J Chem Engin. 2001; 79(2): 177-86
  • 40. Rackow EC, Mecher C, Astiz ME, Griffel M, Falk JL, Weil MH. Effects of pentastarch and albumin infusion on cardiorespiratory function and coagulation in patients with severe sepsis and systemic hypoperfusion. Crit Care Med. 1989; 17(5): 394-8[PubMed]
  • 41. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001; 345(19): 1368-77[DOI][PubMed]
  • 42. Wilkes MM, Navickis RJ. Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials. Ann Intern Med. 2001; 135(3): 149-64[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments