Iranian Red Crescent Medical Journal

Published by: Kowsar

The Effect of Probiotic Yogurt on Constipation in Pregnant Women: A Randomized Controlled Clinical Trial

Mojgan Mirghafourvand 1 , Aziz Homayouni Rad 2 , Sakineh Mohammad Alizadeh Charandabi 1 , Zahra Fardiazar 3 and Kolsoum Shokri 4 , *
Authors Information
1 Midwifery Department, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran
2 Department of Food Science and Technology, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, IR Iran
3 Women Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, IR Iran
4 Students Research Committee, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: November 01, 2016, 18 (11); e39870
  • Published Online: October 1, 2016
  • Article Type: Research Article
  • Received: June 10, 2016
  • Revised: July 12, 2016
  • Accepted: August 13, 2016
  • DOI: 10.5812/ircmj.39870

To Cite: Mirghafourvand M, Homayouni Rad A, Mohammad Alizadeh Charandabi S, Fardiazar Z, Shokri K. The Effect of Probiotic Yogurt on Constipation in Pregnant Women: A Randomized Controlled Clinical Trial, Iran Red Crescent Med J. 2016 ; 18(11):e39870. doi: 10.5812/ircmj.39870.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Cullen G, O'Donoghue D. Constipation and pregnancy. Best Pract Res Clin Gastroenterol. 2007; 21(5): 807-18[DOI][PubMed]
  • 2. Chu H, Zhong L, Li H, Zhang X, Zhang J, Hou X. Epidemiology characteristics of constipation for general population, pediatric population, and elderly population in china. Gastroenterol Res Pract. 2014; 2014: 532734[DOI][PubMed]
  • 3. Liu LW. Chronic constipation: current treatment options. Can J Gastroenterol. 2011; 25 Suppl B: 22B-8B[PubMed]
  • 4. Belsey J, Greenfield S, Candy D, Geraint M. Systematic review: impact of constipation on quality of life in adults and children. Aliment Pharmacol Ther. 2010; 31(9): 938-49[DOI][PubMed]
  • 5. Amselem C, Puigdollers A, Azpiroz F, Sala C, Videla S, Fernandez-Fraga X, et al. Constipation: a potential cause of pelvic floor damage? Neurogastroenterol Motil. 2010; 22(2): 150-3[DOI][PubMed]
  • 6. Ford AC, Moayyedi P, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation. Am J Gastroenterol. 2014; 109 Suppl 1-26[DOI][PubMed]
  • 7. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006; 130(5): 1480-91[DOI][PubMed]
  • 8. Mulak A, Tache Y, Larauche M. Sex hormones in the modulation of irritable bowel syndrome. World J Gastroenterol. 2014; 20(10): 2433-48[DOI][PubMed]
  • 9. Trottier M, Erebara A, Bozzo P. Treating constipation during pregnancy. Can Fam Physician. 2012; 58(8): 836-8[PubMed]
  • 10. Pillitteri A. Maternal and child health nursing: Care of the childbearing and childrearing family. 2010;
  • 11. Slavin JL. Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc. 2008; 108(10): 1716-31[PubMed]
  • 12. Blaker P, Wilkinson M. Chronic constipation: diagnosis and current treatment options. Prescriber. 2010; 21(9): 30-45
  • 13. Jayasimhan S, Yap NY, Roest Y, Rajandram R, Chin KF. Efficacy of microbial cell preparation in improving chronic constipation: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2013; 32(6): 928-34[DOI][PubMed]
  • 14. Longo SA, Moore RC, Canzoneri BJ, Robichaux A. Gastrointestinal Conditions during Pregnancy. Clin Colon Rectal Surg. 2010; 23(2): 80-9[DOI][PubMed]
  • 15. Homayouni A. Letter to the editor. Food Chem. 2009; 114: 1073
  • 16. Singh VP, Sharma J, Babu S, Singla A. Role of probiotics in health and disease: a review. J Pak Med Assoc. 2013; 63(2): 253-7[PubMed]
  • 17. Agrawal A, Houghton LA, Morris J, Reilly B, Guyonnet D, Goupil Feuillerat N, et al. Clinical trial: the effects of a fermented milk product containing Bifidobacterium lactis DN-173 010 on abdominal distension and gastrointestinal transit in irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2009; 29(1): 104-14[DOI][PubMed]
  • 18. Guyonnet D, Chassany O, Ducrotte P, Picard C, Mouret M, Mercier CH, et al. Effect of a fermented milk containing Bifidobacterium animalis DN-173 010 on the health-related quality of life and symptoms in irritable bowel syndrome in adults in primary care: a multicentre, randomized, double-blind, controlled trial. Aliment Pharmacol Ther. 2007; 26(3): 475-86[DOI][PubMed]
  • 19. Bouvier M, Meance S, Bouley C, Berta J, Grimaud J. Effects of consumptionof a milk fermented by the probiotic strain bifidobacterium animalis DN-173 010 on colonic transit times in healthy humans. Bioscience Microflora. 2001; 20(2): 43-8
  • 20. de Milliano I, Tabbers MM, van der Post JA, Benninga MA. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Nutr J. 2012; 11: 80[DOI][PubMed]
  • 21. Tateyama I, Hashii K, Johno I, Iino T, Hirai K, Suwa Y, et al. Effect of xylooligosaccharide intake on severe constipation in pregnant women. J Nutr Sci Vitaminol (Tokyo). 2005; 51(6): 445-8[PubMed]
  • 22. Mortazavian AM, Ehsani MR, Sohrabvandi S, Reinheimer JA. MRS-bile agar: its suitability for the enumeration of mixed probiotic cultures in cultured dairy products. Milchwissenschaft. 2007; 62(3): 270-2
  • 23. Homayouni A, Ehsani MR, Azizi A, Razavi SH, Yarmand MS. Spectrophotometricaly evaluation of probiotic growth in liquid media. Asian Journal of Chemistry. 2008; 20(3): 2414-20
  • 24. Homayouni Rad A. Therapeutical effects of functional probiotic, prebiotic and synbiotic foods. 2008;
  • 25. Nabavi S, Rafraf M, Somi MH, Homayouni-Rad A, Asghari-Jafarabadi M. Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease. Journal of Dairy Science. 2014; (12): 7386-93[DOI][PubMed]
  • 26. Homayouni A, Payahoo L, Azizi A. Effects of probiotics on lipid profile: A review. American Journal of Food Technology. 2012; (5): 251-65[DOI]
  • 27. Ejtahed H, Mohtadi Nia J, Homayouni Rad A, Niafar M, Asghari Jafarabadi M, Mofid V, et al. The effects of probiotic and conventional yoghurt on diabetes markers and insulin resistance in type 2 diabetic patients: A randomized controlled clinical trial. [in Persian] Iranian Journal of Endocrinology and Metabolism. 2011; 13(1): 112
  • 28. Homayouni A, Azizi A, Javadi M, Mahdipour S, Ejtahed H. Factors influencing probiotic survival in ice cream: A review. Int J Dairy Sci. 2012; 7: 1-10[DOI]
  • 29. Ferdousi R, Rouhi M, Mohammadi R, Mortazavian AM, Khosravi-Darani K, Rad AH. Evaluation of probiotic survivability in yogurt exposed to cold chain interruption. Iranian Journal of Pharmaceutical Research. 2013; (12): 137-42
  • 30. Homayoni Rad A, Mehrabany EV, Alipoor B, Mehrabany LV, Javadi M. Do probiotics act more efficiently in foods than in supplements? Nutrition 2012; (28): 733-6
  • 31. Collete V, Araujo C, Madruga S. Prevalência e fatores associados a constipacao intestinal: um estudo de base populacional em Pelotas, Rio Grande do Sul, Brasil, 2007. Cad saude publica. 2010; 26(7): 1391-402
  • 32. Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B. The Short Form Health Survey (SF-36): translation and validation study of the Iranian version. Qual Life Res. 2005; 14(3): 875-82[PubMed]
  • 33. An HM, Baek EH, Jang S, Lee DK, Kim MJ, Kim JR, et al. Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents. Nutr J. 2010; 9: 5[DOI][PubMed]
  • 34. Yang YX, He M, Hu G, Wei J, Pages P, Yang XH, et al. Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol. 2008; 14(40): 6237-43[PubMed]
  • 35. Coccorullo P, Strisciuglio C, Martinelli M, Miele E, Greco L, Staiano A. Lactobacillus reuteri (DSM 17938) in infants with functional chronic constipation: a double-blind, randomized, placebo-controlled study. J Pediatr. 2010; 157(4): 598-602[DOI][PubMed]
  • 36. Benton D, Williams C, Brown A. Impact of consuming a milk drink containing a probiotic on mood and cognition. European J Clin Nutr. 2007; 61(3): 355-61
  • 37. Pelczar MJ. Microbiology. 1986;
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments