Iranian Red Crescent Medical Journal

Published by: Kowsar

Familial Aggregation of Metabolic Syndrome With Different Socio-Behavioral Characteristics: The Fourth Phase of Tehran Lipid and Glucose Study

Maryam Zarkesh 1 , Golaleh Asghari 2 , Parisa Amiri 3 , * , Nima Hosseinzadeh 1 , Mehdi Hedayati 1 , Arash Ghanbarian 4 and Fereidoun Azizi 5
Authors Information
1 Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
3 Research Center for Social Determinants of Endocrine Health and Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4 Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
5 Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: August 01, 2016, 18 (8); e30104
  • Published Online: June 20, 2016
  • Article Type: Research Article
  • Received: May 20, 2015
  • Revised: July 9, 2015
  • Accepted: August 15, 2015
  • DOI: 10.5812/ircmj.30104

To Cite: Zarkesh M, Asghari G, Amiri P, Hosseinzadeh N, Hedayati M, et al. Familial Aggregation of Metabolic Syndrome With Different Socio-Behavioral Characteristics: The Fourth Phase of Tehran Lipid and Glucose Study, Iran Red Crescent Med J. 2016 ; 18(8):e30104. doi: 10.5812/ircmj.30104.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Pandit K, Goswami S, Ghosh S, Mukhopadhyay P, Chowdhury S. Metabolic syndrome in South Asians. Indian J Endocrinol Metab. 2012; 16(1): 44-55[DOI][PubMed]
  • 2. Azizi F, Salehi P, Etemadi A, Zahedi-Asl S. Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study. Diabetes Res Clin Pract. 2003; 61(1): 29-37[PubMed]
  • 3. Stockl D, Meisinger C, Peters A, Thorand B, Huth C, Heier M, et al. Age at menarche and its association with the metabolic syndrome and its components: results from the KORA F4 study. PLoS One. 2011; 6(10): 26076[DOI][PubMed]
  • 4. Jermendy G, Horvath T, Littvay L, Steinbach R, Jermendy AL, Tarnoki AD, et al. Effect of genetic and environmental influences on cardiometabolic risk factors: a twin study. Cardiovasc Diabetol. 2011; 10: 96[DOI][PubMed]
  • 5. Zarkesh M, Daneshpour MS, Faam B, Fallah MS, Hosseinzadeh N, Guity K, et al. Heritability of the metabolic syndrome and its components in the Tehran Lipid and Glucose Study (TLGS). Genet Res (Camb). 2012; 94(6): 331-7[DOI][PubMed]
  • 6. Tam CH, Lam VK, So WY, Ma RC, Chan JC, Ng MC. Genome-wide linkage scan for factors of metabolic syndrome in a Chinese population. BMC Genet. 2010; 11: 14[DOI][PubMed]
  • 7. Silventoinen K, Pankow J, Jousilahti P, Hu G, Tuomilehto J. Educational inequalities in the metabolic syndrome and coronary heart disease among middle-aged men and women. Int J Epidemiol. 2005; 34(2): 327-34[DOI][PubMed]
  • 8. Clarke J, Janssen I. Is the frequency of weekly moderate-to-vigorous physical activity associated with the metabolic syndrome in Canadian adults? Appl Physiol Nutr Metab. 2013; 38(7): 773-8[DOI][PubMed]
  • 9. Joung H, Hong S, Song Y, Ahn BC, Park MJ. Dietary patterns and metabolic syndrome risk factors among adolescents. Korean J Pediatr. 2012; 55(4): 128-35[DOI][PubMed]
  • 10. Chiu YH, Lin WY, Wang PE, Chen YD, Wang TT, Warwick J, et al. Population-based family case-control proband study on familial aggregation of metabolic syndrome: finding from Taiwanese people involved in Keelung community-based integrated screening (KCIS no. 5). Diabetes Res Clin Pract. 2007; 75(3): 348-56[DOI][PubMed]
  • 11. Janghorbani M, Amini M. Metabolic syndrome in first degree relatives of patients with type 2 diabetes: Incidence and risk factors. Diabetes Metab Syndr. 2011; 5(4): 201-6[DOI][PubMed]
  • 12. Merchant AT, Jethwani M, Choi YH, Morrato EH, Liese AD, Mayer-Davis E. Associations between periodontal disease and selected risk factors of early complications among youth with type 1 and type 2 diabetes: a pilot study. Pediatr Diabetes. 2011; 12(6): 529-35[DOI][PubMed]
  • 13. Azizi F, Ghanbarian A, Momenan AA, Hadaegh F, Mirmiran P, Hedayati M, et al. Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II. Trials. 2009; 10: 5[DOI][PubMed]
  • 14. Kriska AM, Edelstein SL, Hamman RF, Otto A, Bray GA, Mayer-Davis EJ, et al. Physical activity in individuals at risk for diabetes: Diabetes Prevention Program. Med Sci Sports Exerc. 2006; 38(5): 826-32[DOI][PubMed]
  • 15. Momenan AA, Delshad M, Sarbazi N, Rezaei Ghaleh N, Ghanbarian A, Azizi F. Reliability and validity of the Modifiable Activity Questionnaire (MAQ) in an Iranian urban adult population. Arch Iran Med. 2012; 15(5): 279-82[PubMed]
  • 16. Sesso HD, Paffenbarger RS, Lee IM. Physical activity and coronary heart disease in men: The Harvard Alumni Health Study. Circulation. 2000; 102(9): 975-80
  • 17. Asghari G, Rezazadeh A, Hosseini-Esfahani F, Mehrabi Y, Mirmiran P, Azizi F. Reliability, comparative validity and stability of dietary patterns derived from an FFQ in the Tehran Lipid and Glucose Study. Br J Nutr. 2012; 108(6): 1109-17[DOI][PubMed]
  • 18. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009; 120(16): 1640-5[DOI][PubMed]
  • 19. Delavari A, Forouzanfar MH, Alikhani S, Sharifian A, Kelishadi R. First nationwide study of the prevalence of the metabolic syndrome and optimal cutoff points of waist circumference in the Middle East: the national survey of risk factors for noncommunicable diseases of Iran. Diabetes Care. 2009; 32(6): 1092-7[DOI][PubMed]
  • 20. Liang KY, Pulver AE. Analysis of case-control/family sampling design. Genet Epidemiol. 1996; 13(3): 253-70[DOI][PubMed]
  • 21. Azizi F, Farahani ZK, Ghanbarian A, Sheikholeslami F, Mirmiran P, Momenan AA, et al. Familial aggregation of the metabolic syndrome: Tehran Lipid and Glucose Study. Ann Nutr Metab. 2009; 54(3): 189-96[DOI][PubMed]
  • 22. Zarkesh M, Hosseinpanah F, Barzin M, Hosseinzadeh N, Guity K, Daneshpour MS, et al. Recurrence risk ratio of siblings and familial aggregation of the metabolic syndrome among Tehranian population. Arch Iran Med. 2014; 17(6): 411-6[PubMed]
  • 23. Yoo EG, Park SS, Oh SW, Nam GB, Park MJ. Strong parent-offspring association of metabolic syndrome in Korean families. Diabetes Care. 2012; 35(2): 293-5[PubMed]
  • 24. Feng Y, Zang T, Xu X, Xu X. Familial aggregation of metabolic syndrome and its components in a large Chinese population. Obesity (Silver Spring). 2008; 16(1): 125-9[DOI][PubMed]
  • 25. Lee KE, Klein BE, Klein R. Familial aggregation of components of the multiple metabolic syndrome in the Framingham Heart and Offspring Cohorts: Genetic Analysis Workshop Problem 1. BMC Genet. 2003; 4 Suppl 1: 94[DOI][PubMed]
  • 26. Carmelli D, Cardon LR, Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet. 1994; 55(3): 566-73[PubMed]
  • 27. Santos DM, Katzmarzyk PT, Tregouet DA, Gomes TN, Santos FK, Maia JA. Familial aggregation of metabolic syndrome indicators in Portuguese families. Biomed Res Int. 2013; 2013: 314823[DOI][PubMed]
  • 28. Zhu S, St-Onge MP, Heshka S, Heymsfield SB. Lifestyle behaviors associated with lower risk of having the metabolic syndrome. Metabolism. 2004; 53(11): 1503-11[PubMed]
  • 29. Wilsgaard T, Jacobsen BK. Lifestyle factors and incident metabolic syndrome. The Tromso Study 1979-2001. Diabetes Res Clin Pract. 2007; 78(2): 217-24[DOI][PubMed]
  • 30. Ngo AD, Paquet C, Howard NJ, Coffee NT, Adams R, Taylor A, et al. Area-level socioeconomic characteristics and incidence of metabolic syndrome: a prospective cohort study. BMC Public Health. 2013; 13: 681[DOI][PubMed]
  • 31. Diez-Roux AV, Link BG, Northridge ME. A multilevel analysis of income inequality and cardiovascular disease risk factors. Soc Sci Med. 2000; 50(5): 673-87[PubMed]
  • 32. Frontini MG, Srinivasan SR, Berenson GS. Longitudinal changes in risk variables underlying metabolic Syndrome X from childhood to young adulthood in female subjects with a history of early menarche: the Bogalusa Heart Study. Int J Obes Relat Metab Disord. 2003; 27(11): 1398-404[DOI][PubMed]
  • 33. Dhingra R, Sullivan L, Jacques PF, Wang TJ, Fox CS, Meigs JB, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. 2007; 116(5): 480-8[DOI][PubMed]
  • 34. Nettleton JA, Lutsey PL, Wang Y, Lima JA, Michos ED, Jacobs DR. Diet soda intake and risk of incident metabolic syndrome and type 2 diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2009; 32(4): 688-94[DOI][PubMed]
  • 35. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am J Clin Nutr. 2004; 79(4): 537-43[PubMed]
  • 36. Elliott SS, Keim NL, Stern JS, Teff K, Havel PJ. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr. 2002; 76(5): 911-22[PubMed]
  • 37. Hosseini-Esfahani F, Bahadoran Z, Mirmiran P, Hosseinpour-Niazi S, Hosseinpanah F, Azizi F. Dietary fructose and risk of metabolic syndrome in adults: Tehran Lipid and Glucose study. Nutr Metab (Lond). 2011; 8(1): 50[DOI][PubMed]
  • 38. Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, et al. Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes. 2002; 51(7): 2082-9[PubMed]
  • 39. Vlassara H, Cai W, Crandall J, Goldberg T, Oberstein R, Dardaine V, et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A. 2002; 99(24): 15596-601[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments