Iranian Red Crescent Medical Journal

Published by: Kowsar

Protective Effects of Co-Enzyme Q10 on Thioacetamide-Induced Acute Liver Damage and Its Correlation With Behavioral, Biochemical, and Pathological Factors

Soheil Ashkani-Esfahani 1 , Fereshteh Bagheri 1 , Yasaman Emami 1 , Elmira Esmaeilzadeh 1 , Negar Azarpira 2 , Nazila Hassanabadi 1 , Marzieh Keshtkar 3 , Mojtaba Farjam 4 , Omid Koohi-Hosseinabadi 5 and Ali Noorafshan 6 , *
Authors Information
1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 International Branch, Shiraz University of Medical Sciences, Kish, IR Iran
4 Department Of Pharmacology, Fasa University of Medical Sciences, Shiraz, IR Iran
5 Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
6 Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: August 01, 2016, 18 (8); e29166
  • Published Online: June 19, 2016
  • Article Type: Research Article
  • Received: April 14, 2015
  • Revised: August 29, 2015
  • Accepted: September 26, 2015
  • DOI: 10.5812/ircmj.29166

To Cite: Ashkani-Esfahani S, Bagheri F, Emami Y, Esmaeilzadeh E, Azarpira N, et al. Protective Effects of Co-Enzyme Q10 on Thioacetamide-Induced Acute Liver Damage and Its Correlation With Behavioral, Biochemical, and Pathological Factors, Iran Red Crescent Med J. 2016 ; 18(8):e29166. doi: 10.5812/ircmj.29166.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Bernal W, Hall C, Karvellas CJ, Auzinger G, Sizer E, Wendon J. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology. 2007; 46(6): 1844-52[DOI][PubMed]
  • 2. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002; 35(3): 716-21[DOI][PubMed]
  • 3. Rama Rao KV, Norenberg MD. Aquaporin-4 in hepatic encephalopathy. Metab Brain Dis. 2007; 22(3-4): 265-75[DOI][PubMed]
  • 4. Lockwood AH. Blood ammonia levels and hepatic encephalopathy. Metab Brain Dis. 2004; 19(3-4): 345-9[PubMed]
  • 5. Bemeur C, Desjardins P, Butterworth RF. Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy. Metab Brain Dis. 2010; 25(1): 3-9[DOI][PubMed]
  • 6. Wang M, Sang S, Hwang LS, Ho CT. Challenges in chemistry and biology : American chemical society . 2006; 925[DOI]
  • 7. Molyneux SL, Young JM, Florkowski CM, Lever M, George PM. Coenzyme Q10: is there a clinical role and a case for measurement? Clin Biochem Rev. 2008; 29(2): 71-82[PubMed]
  • 8. Sumien N, Heinrich KR, Shetty RA, Sohal RS, Forster MJ. Prolonged intake of coenzyme Q10 impairs cognitive functions in mice. J Nutr. 2009; 139(10): 1926-32[DOI][PubMed]
  • 9. Moon Y, Lee KH, Park JH, Geum D, Kim K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10. J Neurochem. 2005; 93(5): 1199-208[DOI][PubMed]
  • 10. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007; 21(4): 297-306[DOI][PubMed]
  • 11. Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors. 2003; 18(1-4): 91-100[PubMed]
  • 12. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008; 24(4): 293-9[DOI][PubMed]
  • 13. Ashkani Esfahani S, Esmaeilzadeh E, Bagheri F, Emami Y, Farjam M. The effect of co-enzyme q10 on acute liver damage in rats, a biochemical and pathological study. Hepat Mon. 2013; 13(8): 13685[DOI][PubMed]
  • 14. Chu CJ, Lee FY, Wang SS, Chang FY, Lin HC, Wu SL, et al. Establishment of an animal model of hepatic encephalopathy. Zhonghua Yi Xue Za Zhi (Taipei). 2000; 63(4): 263-9[PubMed]
  • 15. Theocharis SE, Margeli AP, Agapitos EV, Mykoniatis MG, Kittas CN, Davaris PS. Effect of hepatic stimulator substance administration on tissue regeneration due to thioacetamide-induced liver injury in rats. Scand J Gastroenterol. 1998; 33(6): 656-63[PubMed]
  • 16. Farjam M, Dehdab P, Abbassnia F, Mehrabani D, Tanideh N, Pakbaz S, et al. Thioacetamide-induced acute hepatic encephalopathy in rat: behavioral, biochemical and histological changes. Iran Red Crescent Med J. 2012; 14(3): 164-70[PubMed]
  • 17. Bengtsson F, Gage FH, Jeppsson B, Nobin A, Rosengren E. Brain monoamine metabolism and behavior in portacaval-shunted rats. Exp Neurol. 1985; 90(1): 21-35[PubMed]
  • 18. Walf AA, Frye CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2007; 2(2): 322-8[DOI][PubMed]
  • 19. Wilson CA, Vazdarjanova A, Terry AJ. Exposure to variable prenatal stress in rats: effects on anxiety-related behaviors, innate and contextual fear, and fear extinction. Behav Brain Res. 2013; 238: 279-88[DOI][PubMed]
  • 20. Kilic FS, Ozatik Y, Kaygisiz B, Baydemir C, Erol K. Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats. Neurosciences (Riyadh). 2012; 17(1): 39-43[PubMed]
  • 21. Shankar K, Vaidya VS, Wang T, Bucci TJ, Mehendale HM. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol Appl Pharmacol. 2003; 188(2): 122-34[PubMed]
  • 22. Shults CW, Haas R. Clinical trials of coenzyme Q10 in neurological disorders. Biofactors. 2005; 25(1-4): 117-26[PubMed]
  • 23. Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatr Dis Treat. 2009; 5: 597-610[PubMed]
  • 24. Smith KM, Matson S, Matson WR, Cormier K, Del Signore SJ, Hagerty SW, et al. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. Biochim Biophys Acta. 2006; 1762(6): 616-26[DOI][PubMed]
  • 25. Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci. 2008; 1147: 395-412[DOI][PubMed]
  • 26. Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol. 2008; 4(11): 600-9[DOI][PubMed]
  • 27. Bentinger M, Tekle M, Dallner G. Coenzyme Q--biosynthesis and functions. Biochem Biophys Res Commun. 2010; 396(1): 74-9[DOI][PubMed]
  • 28. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Nutrition. 2010; 26(3): 250-4[DOI][PubMed]
  • 29. Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, et al. Clinical applications of coenzyme Q10. Front Biosci (Landmark Ed). 2014; 19: 619-33[PubMed]
  • 30. Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Fernandez Vega A, de la Mata M, Delgado Pavon A, et al. Coenzyme q10 therapy. Mol Syndromol. 2014; 5(3-4): 187-97[DOI][PubMed]
  • 31. Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, Pandey S. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis. 2005; 18(3): 618-27[DOI][PubMed]
  • 32. Kasparova S, Sumbalova Z, Bystricky P, Kucharska J, Liptaj T, Mlynarik V, et al. Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease. Neurochem Int. 2006; 48(2): 93-9[DOI][PubMed]
  • 33. Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA. Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation. Biofactors. 2005; 25(1-4): 147-52[PubMed]
  • 34. Kosenko E, Venediktova N, Kaminsky Y, Montoliu C, Felipo V. Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res. 2003; 981(1-2): 193-200[PubMed]
  • 35. Norenberg MD, Jayakumar AR, Rama Rao KV, Panickar KS. New concepts in the mechanism of ammonia-induced astrocyte swelling. Metab Brain Dis. 2007; 22(3-4): 219-34[DOI][PubMed]
  • 36. Warskulat U, Gorg B, Bidmon HJ, Muller HW, Schliess F, Haussinger D. Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo. Glia. 2002; 40(3): 324-36[DOI][PubMed]
  • 37. Stravitz RT, Sanyal AJ, Reisch J, Bajaj JS, Mirshahi F, Cheng J, et al. Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival. Liver Int. 2013; 33(9): 1324-31[DOI][PubMed]
  • 38. Norenberg MD. Oxidative and nitrosative stress in ammonia neurotoxicity. Hepatology. 2003; 37(2): 245-8[DOI][PubMed]
  • 39. Fouad AA, Jresat I. Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. Environ Toxicol Pharmacol. 2012; 33(2): 158-67[DOI][PubMed]
  • 40. Othman AA, Shoheib ZS, Abdel-Aleem GA, Shareef MM. Experimental schistosomal hepatitis: protective effect of coenzyme-Q10 against the state of oxidative stress. Exp Parasitol. 2008; 120(2): 147-55[DOI][PubMed]
  • 41. Sinatra DS, Sinatra ST, Heyser CJ. The effects of Coenzyme Q10 on locomotor and behavioral activity in young and aged C57BL/6 mice. Biofactors. 2003; 18(1-4): 283-7[PubMed]
  • 42. Gardner A, Boles RG. Symptoms of somatization as a rapid screening tool for mitochondrial dysfunction in depression. Biopsychosoc Med. 2008; 2: 7[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments