Iranian Red Crescent Medical Journal

Published by: Kowsar

Protective Effects of Co-Enzyme Q10 on Thioacetamide-Induced Acute Liver Damage and Its Correlation With Behavioral, Biochemical, and Pathological Factors

Soheil Ashkani-Esfahani 1 , Fereshteh Bagheri 1 , Yasaman Emami 1 , Elmira Esmaeilzadeh 1 , Negar Azarpira 2 , Nazila Hassanabadi 1 , Marzieh Keshtkar 3 , Mojtaba Farjam 4 , Omid Koohi-Hosseinabadi 5 and Ali Noorafshan 6 , *
Authors Information
1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 International Branch, Shiraz University of Medical Sciences, Kish, IR Iran
4 Department Of Pharmacology, Fasa University of Medical Sciences, Shiraz, IR Iran
5 Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
6 Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: August 01, 2016, 18 (8); e29166
  • Published Online: June 19, 2016
  • Article Type: Research Article
  • Received: April 14, 2015
  • Revised: August 29, 2015
  • Accepted: September 26, 2015
  • DOI: 10.5812/ircmj.29166

To Cite: Ashkani-Esfahani S, Bagheri F, Emami Y, Esmaeilzadeh E, Azarpira N, et al. Protective Effects of Co-Enzyme Q10 on Thioacetamide-Induced Acute Liver Damage and Its Correlation With Behavioral, Biochemical, and Pathological Factors, Iran Red Crescent Med J. 2016 ; 18(8):e29166. doi: 10.5812/ircmj.29166.

Abstract
Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Bernal W, Hall C, Karvellas CJ, Auzinger G, Sizer E, Wendon J. Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure. Hepatology. 2007; 46(6): 1844-52[DOI][PubMed]
  • 2. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy--definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002; 35(3): 716-21[DOI][PubMed]
  • 3. Rama Rao KV, Norenberg MD. Aquaporin-4 in hepatic encephalopathy. Metab Brain Dis. 2007; 22(3-4): 265-75[DOI][PubMed]
  • 4. Lockwood AH. Blood ammonia levels and hepatic encephalopathy. Metab Brain Dis. 2004; 19(3-4): 345-9[PubMed]
  • 5. Bemeur C, Desjardins P, Butterworth RF. Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy. Metab Brain Dis. 2010; 25(1): 3-9[DOI][PubMed]
  • 6. Wang M, Sang S, Hwang LS, Ho CT. Challenges in chemistry and biology : American chemical society . 2006; 925[DOI]
  • 7. Molyneux SL, Young JM, Florkowski CM, Lever M, George PM. Coenzyme Q10: is there a clinical role and a case for measurement? Clin Biochem Rev. 2008; 29(2): 71-82[PubMed]
  • 8. Sumien N, Heinrich KR, Shetty RA, Sohal RS, Forster MJ. Prolonged intake of coenzyme Q10 impairs cognitive functions in mice. J Nutr. 2009; 139(10): 1926-32[DOI][PubMed]
  • 9. Moon Y, Lee KH, Park JH, Geum D, Kim K. Mitochondrial membrane depolarization and the selective death of dopaminergic neurons by rotenone: protective effect of coenzyme Q10. J Neurochem. 2005; 93(5): 1199-208[DOI][PubMed]
  • 10. Rosenfeldt FL, Haas SJ, Krum H, Hadj A, Ng K, Leong JY, et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007; 21(4): 297-306[DOI][PubMed]
  • 11. Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure. Biofactors. 2003; 18(1-4): 91-100[PubMed]
  • 12. Mizuno K, Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, et al. Antifatigue effects of coenzyme Q10 during physical fatigue. Nutrition. 2008; 24(4): 293-9[DOI][PubMed]
  • 13. Ashkani Esfahani S, Esmaeilzadeh E, Bagheri F, Emami Y, Farjam M. The effect of co-enzyme q10 on acute liver damage in rats, a biochemical and pathological study. Hepat Mon. 2013; 13(8): 13685[DOI][PubMed]
  • 14. Chu CJ, Lee FY, Wang SS, Chang FY, Lin HC, Wu SL, et al. Establishment of an animal model of hepatic encephalopathy. Zhonghua Yi Xue Za Zhi (Taipei). 2000; 63(4): 263-9[PubMed]
  • 15. Theocharis SE, Margeli AP, Agapitos EV, Mykoniatis MG, Kittas CN, Davaris PS. Effect of hepatic stimulator substance administration on tissue regeneration due to thioacetamide-induced liver injury in rats. Scand J Gastroenterol. 1998; 33(6): 656-63[PubMed]
  • 16. Farjam M, Dehdab P, Abbassnia F, Mehrabani D, Tanideh N, Pakbaz S, et al. Thioacetamide-induced acute hepatic encephalopathy in rat: behavioral, biochemical and histological changes. Iran Red Crescent Med J. 2012; 14(3): 164-70[PubMed]
  • 17. Bengtsson F, Gage FH, Jeppsson B, Nobin A, Rosengren E. Brain monoamine metabolism and behavior in portacaval-shunted rats. Exp Neurol. 1985; 90(1): 21-35[PubMed]
  • 18. Walf AA, Frye CA. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2007; 2(2): 322-8[DOI][PubMed]
  • 19. Wilson CA, Vazdarjanova A, Terry AJ. Exposure to variable prenatal stress in rats: effects on anxiety-related behaviors, innate and contextual fear, and fear extinction. Behav Brain Res. 2013; 238: 279-88[DOI][PubMed]
  • 20. Kilic FS, Ozatik Y, Kaygisiz B, Baydemir C, Erol K. Acute antidepressant and anxiolytic effects of simvastatin and its mechanisms in rats. Neurosciences (Riyadh). 2012; 17(1): 39-43[PubMed]
  • 21. Shankar K, Vaidya VS, Wang T, Bucci TJ, Mehendale HM. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol Appl Pharmacol. 2003; 188(2): 122-34[PubMed]
  • 22. Shults CW, Haas R. Clinical trials of coenzyme Q10 in neurological disorders. Biofactors. 2005; 25(1-4): 117-26[PubMed]
  • 23. Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. Neuropsychiatr Dis Treat. 2009; 5: 597-610[PubMed]
  • 24. Smith KM, Matson S, Matson WR, Cormier K, Del Signore SJ, Hagerty SW, et al. Dose ranging and efficacy study of high-dose coenzyme Q10 formulations in Huntington's disease mice. Biochim Biophys Acta. 2006; 1762(6): 616-26[DOI][PubMed]
  • 25. Chaturvedi RK, Beal MF. Mitochondrial approaches for neuroprotection. Ann N Y Acad Sci. 2008; 1147: 395-412[DOI][PubMed]
  • 26. Henchcliffe C, Beal MF. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol. 2008; 4(11): 600-9[DOI][PubMed]
  • 27. Bentinger M, Tekle M, Dallner G. Coenzyme Q--biosynthesis and functions. Biochem Biophys Res Commun. 2010; 396(1): 74-9[DOI][PubMed]
  • 28. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Nutrition. 2010; 26(3): 250-4[DOI][PubMed]
  • 29. Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, et al. Clinical applications of coenzyme Q10. Front Biosci (Landmark Ed). 2014; 19: 619-33[PubMed]
  • 30. Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Fernandez Vega A, de la Mata M, Delgado Pavon A, et al. Coenzyme q10 therapy. Mol Syndromol. 2014; 5(3-4): 187-97[DOI][PubMed]
  • 31. Somayajulu M, McCarthy S, Hung M, Sikorska M, Borowy-Borowski H, Pandey S. Role of mitochondria in neuronal cell death induced by oxidative stress; neuroprotection by Coenzyme Q10. Neurobiol Dis. 2005; 18(3): 618-27[DOI][PubMed]
  • 32. Kasparova S, Sumbalova Z, Bystricky P, Kucharska J, Liptaj T, Mlynarik V, et al. Effect of coenzyme Q10 and vitamin E on brain energy metabolism in the animal model of Huntington's disease. Neurochem Int. 2006; 48(2): 93-9[DOI][PubMed]
  • 33. Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA. Treatment of statin adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation. Biofactors. 2005; 25(1-4): 147-52[PubMed]
  • 34. Kosenko E, Venediktova N, Kaminsky Y, Montoliu C, Felipo V. Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res. 2003; 981(1-2): 193-200[PubMed]
  • 35. Norenberg MD, Jayakumar AR, Rama Rao KV, Panickar KS. New concepts in the mechanism of ammonia-induced astrocyte swelling. Metab Brain Dis. 2007; 22(3-4): 219-34[DOI][PubMed]
  • 36. Warskulat U, Gorg B, Bidmon HJ, Muller HW, Schliess F, Haussinger D. Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo. Glia. 2002; 40(3): 324-36[DOI][PubMed]
  • 37. Stravitz RT, Sanyal AJ, Reisch J, Bajaj JS, Mirshahi F, Cheng J, et al. Effects of N-acetylcysteine on cytokines in non-acetaminophen acute liver failure: potential mechanism of improvement in transplant-free survival. Liver Int. 2013; 33(9): 1324-31[DOI][PubMed]
  • 38. Norenberg MD. Oxidative and nitrosative stress in ammonia neurotoxicity. Hepatology. 2003; 37(2): 245-8[DOI][PubMed]
  • 39. Fouad AA, Jresat I. Hepatoprotective effect of coenzyme Q10 in rats with acetaminophen toxicity. Environ Toxicol Pharmacol. 2012; 33(2): 158-67[DOI][PubMed]
  • 40. Othman AA, Shoheib ZS, Abdel-Aleem GA, Shareef MM. Experimental schistosomal hepatitis: protective effect of coenzyme-Q10 against the state of oxidative stress. Exp Parasitol. 2008; 120(2): 147-55[DOI][PubMed]
  • 41. Sinatra DS, Sinatra ST, Heyser CJ. The effects of Coenzyme Q10 on locomotor and behavioral activity in young and aged C57BL/6 mice. Biofactors. 2003; 18(1-4): 283-7[PubMed]
  • 42. Gardner A, Boles RG. Symptoms of somatization as a rapid screening tool for mitochondrial dysfunction in depression. Biopsychosoc Med. 2008; 2: 7[DOI][PubMed]
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