Iranian Red Crescent Medical Journal

Published by: Kowsar

Prediction of the Grade of Acute Cholecystitis by Plasma Level of C-Reactive Protein

Esin Kabul Gurbulak 1 , * , Bunyamin Gurbulak 2 , Ismail Ethem Akgun 1 , Yigit Duzkoylu 3 , Muharrem Battal 1 , Mustafa Fevzi Celayir 1 and Uygar Demir 1
Authors Information
1 Department of General Surgery, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey
2 Department of General Surgery, Arnavutkoy State Hospital, Istanbul, Turkey
3 Department of General Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey
Article information
  • Iranian Red Crescent Medical Journal: April 01, 2015, 17 (4); e28091
  • Published Online: April 25, 2015
  • Article Type: Research Article
  • Received: February 19, 2015
  • Revised: March 9, 2015
  • Accepted: March 24, 2015
  • DOI: 10.5812/ircmj.17(4)2015.28091

To Cite: Kabul Gurbulak E, Gurbulak B, Akgun I E, Duzkoylu Y, Battal M, et al. Prediction of the Grade of Acute Cholecystitis by Plasma Level of C-Reactive Protein, Iran Red Crescent Med J. 2015 ; 17(4):e28091. doi: 10.5812/ircmj.17(4)2015.28091.

Copyright © 2015, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Strasberg SM. Clinical practice. Acute calculous cholecystitis. N Engl J Med. 2008; 358(26): 2804-11[DOI][PubMed]
  • 2. Okamoto K, Takada T, Strasberg SM, Solomkin JS, Pitt HA, Garden OJ, et al. TG13 management bundles for acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013; 20(1): 55-9[DOI][PubMed]
  • 3. Mayumi T, Someya K, Ootubo H, Takama T, Kido T, Kamezaki F, et al. Progression of Tokyo Guidelines and Japanese Guidelines for management of acute cholangitis and cholecystitis. J UOEH. 2013; 35(4): 249-57[PubMed]
  • 4. Hirota M, Takada T, Kawarada Y, Nimura Y, Miura F, Hirata K, et al. Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo Guidelines. J Hepatobiliary Pancreat Surg. 2007; 14(1): 78-82[DOI][PubMed]
  • 5. Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, et al. New diagnostic criteria and severity assessment of acute cholecystitis in revised Tokyo Guidelines. J Hepatobiliary Pancreat Sci. 2012; 19(5): 578-85[DOI][PubMed]
  • 6. Vigushin DM, Pepys MB, Hawkins PN. Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease. J Clin Invest. 1993; 91(4): 1351-7[DOI][PubMed]
  • 7. Andersson RE, Hugander AP, Ghazi SH, Ravn H, Offenbartl SK, Nystrom PO, et al. Diagnostic value of disease history, clinical presentation, and inflammatory parameters of appendicitis. World J Surg. 1999; 23(2): 133-40[PubMed]
  • 8. Gronroos JM, Gronroos P. Leucocyte count and C-reactive protein in the diagnosis of acute appendicitis. Br J Surg. 1999; 86(4): 501-4[PubMed]
  • 9. Adamian AI, Guliaev AA, Ivanina TA, Evteeva EA, Samsonov VT. [Acute phase response and plasma proteins in acute cholecystitis]. Klin Lab Diagn. 1997; (11): 8-10[PubMed]
  • 10. Sekimoto M, Imanaka Y, Hirose M, Ishizaki T, Murakami G, Fukata Y, et al. Impact of treatment policies on patient outcomes and resource utilization in acute cholecystitis in Japanese hospitals. BMC Health Serv Res. 2006; 6: 40[DOI][PubMed]
  • 11. Aydin C, Altaca G, Berber I, Tekin K, Kara M, Titiz I. Prognostic parameters for the prediction of acute gangrenous cholecystitis. J Hepatobiliary Pancreat Surg. 2006; 13(2): 155-9[DOI][PubMed]
  • 12. Wevers KP, van Westreenen HL, Patijn GA. Laparoscopic cholecystectomy in acute cholecystitis: C-reactive protein level combined with age predicts conversion. Surg Laparosc Endosc Percutan Tech. 2013; 23(2): 163-6[DOI][PubMed]
  • 13. Mok KW, Reddy R, Wood F, Turner P, Ward JB, Pursnani KG, et al. Is C-reactive protein a useful adjunct in selecting patients for emergency cholecystectomy by predicting severe/gangrenous cholecystitis? Int J Surg. 2014; 12(7): 649-53[DOI][PubMed]
  • 14. Indar AA. Acute cholecystitis. Bmj. 2002; 325(7365): 639-43[DOI]
  • 15. Cho JY, Han HS, Yoon YS, Ahn KS. Risk factors for acute cholecystitis and a complicated clinical course in patients with symptomatic cholelithiasis. Arch Surg. 2010; 145(4): 329-33[DOI][PubMed]
  • 16. Miura F, Takada T, Strasberg SM, Solomkin JS, Pitt HA, Gouma DJ, et al. TG13 flowchart for the management of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013; 20(1): 47-54[DOI][PubMed]
  • 17. Juvonen T, Kiviniemi H, Niemela O, Kairaluoma MI. Diagnostic accuracy of ultrasonography and C reactive protein concentration in acute cholecystitis: a prospective clinical study. Eur J Surg. 1992; 158(6-7): 365-9[PubMed]
  • 18. Durai R, Cheng X, Fernandes C, Razvi A, Ng PC. 'Lewisham scoring system' to facilitate the clinical diagnosis of empyema. Acta Chir Belg. 2010; 110(6): 590-4[PubMed]
  • 19. Nikfarjam M, Niumsawatt V, Sethu A, Fink MA, Muralidharan V, Starkey G, et al. Outcomes of contemporary management of gangrenous and non-gangrenous acute cholecystitis. HPB (Oxford). 2011; 13(8): 551-8[PubMed]
  • 20. Schafer M, Krahenbuhl L, Buchler MW. Predictive factors for the type of surgery in acute cholecystitis. Am J Surg. 2001; 182(3): 291-7[PubMed]
  • 21. Teckchandani N, Garg PK, Hadke NS, Jain SK, Kant R, Mandal AK, et al. Predictive factors for successful early laparoscopic cholecystectomy in acute cholecystitis: a prospective study. Int J Surg. 2010; 8(8): 623-7[DOI][PubMed]
  • 22. Asai K, Watanabe M, Kusachi S, Tanaka H, Matsukiyo H, Osawa A, et al. Bacteriological analysis of bile in acute cholecystitis according to the Tokyo guidelines. J Hepatobiliary Pancreat Sci. 2012; 19(4): 476-86[DOI][PubMed]
  • 23. Licciardello A, Arena M, Nicosia A, Di Stefano B, Cali G, Arena G, et al. Preoperative risk factors for conversion from laparoscopic to open cholecystectomy. Eur Rev Med Pharmacol Sci. 2014; 18(2 Suppl): 60-8[PubMed]
  • 24. Borzellino G, Sauerland S, Minicozzi AM, Verlato G, Di Pietrantonj C, de Manzoni G, et al. Laparoscopic cholecystectomy for severe acute cholecystitis. A meta-analysis of results. Surg Endosc. 2008; 22(1): 8-15[DOI][PubMed]
  • 25. Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999; 340(6): 448-54[DOI][PubMed]
  • 26. Zimmerman MA, Selzman CH, Cothren C, Sorensen AC, Raeburn CD, Harken AH. Diagnostic implications of C-reactive protein. Arch Surg. 2003; 138(2): 220-4[PubMed]
  • 27. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis. 2004; 39(2): 206-17[DOI][PubMed]
  • 28. Cheng WC, Chiu YC, Chuang CH, Chen CY. Assessing clinical outcomes of patients with acute calculous cholecystitis in addition to the Tokyo grading: a retrospective study. Kaohsiung J Med Sci. 2014; 30(9): 459-65[DOI][PubMed]
  • 29. Yokoe M, Takada T, Strasberg SM, Solomkin JS, Mayumi T, Gomi H, et al. TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos). J Hepatobiliary Pancreat Sci. 2013; 20(1): 35-46[DOI][PubMed]
  • 30. Kimura Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ, et al. TG13 current terminology, etiology, and epidemiology of acute cholangitis and cholecystitis. J Hepatobiliary Pancreat Sci. 2013; 20(1): 8-23[DOI][PubMed]
  • 31. Lee SW, Yang SS, Chang CS, Yeh HJ. Impact of the Tokyo guidelines on the management of patients with acute calculous cholecystitis. J Gastroenterol Hepatol. 2009; 24(12): 1857-61[PubMed]
  • 32. Morley JJ, Kushner I. Serum C-reactive protein levels in disease. Ann N Y Acad Sci. 1982; 389: 406-18[PubMed]
  • 33. Mitaka C. Clinical laboratory differentiation of infectious versus non-infectious systemic inflammatory response syndrome. Clin Chim Acta. 2005; 351(1-2): 17-29[DOI][PubMed]
  • 34. Brunkhorst FM, Wegscheider K, Forycki ZF, Brunkhorst R. Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock. Intensive Care Med. 2000; 26 Suppl 2-52[DOI][PubMed]
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