Iranian Red Crescent Medical Journal

Published by: Kowsar

Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause

Mahmood Abedinzade 1 , Sima Nasri 2 , * , Masome Jamal Omodi 2 , Elham Ghasemi 2 and Ahmad Ghorbani 3
Authors Information
1 Medical Biotechnology Research Center, Paramedical School, Guilan University of Medical Sciences, Rasht, IR Iran
2 Department of Biology, Payame Noor University, Tehran, IR Iran
3 Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: November 01, 2015, 17 (11); e26685
  • Published Online: November 16, 2015
  • Article Type: Research Article
  • Received: January 4, 2015
  • Revised: April 1, 2015
  • Accepted: April 21, 2015
  • DOI: 10.5812/ircmj.26685

To Cite: Abedinzade M, Nasri S, Jamal Omodi M, Ghasemi E, Ghorbani A. Efficacy of Trigonella foenum-graecum Seed Extract in Reducing Metabolic and Inflammatory Alterations Associated With Menopause, Iran Red Crescent Med J. 2015 ; 17(11):e26685. doi: 10.5812/ircmj.26685.

Copyright © 2015, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Bulun SE. Williams textbook of endocrinology. 2011; : 581-660
  • 2. Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab. 2003; 88(6): 2404-11[DOI][PubMed]
  • 3. Gaspard U. Hyperinsulinaemia, a key factor of the metabolic syndrome in postmenopausal women. Maturitas. 2009; 62(4): 362-5[DOI][PubMed]
  • 4. Sites CK, Toth MJ, Cushman M, L’Hommedieu GD, Tchernof A, Tracy RP, et al. Menopause-related differences in inflammation markers and their relationship to body fat distribution and insulin-stimulated glucose disposal. Fertility and Sterility. 2002; 77(1): 128-35
  • 5. Rosano GM, Vitale C, Marazzi G, Volterrani M. Menopause and cardiovascular disease: the evidence. Climacteric. 2007; 10 Suppl 1: 19-24[DOI][PubMed]
  • 6. Pacifici R, Brown C, Puscheck E, Friedrich E, Slatopolsky E, Maggio D, et al. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci U S A. 1991; 88(12): 5134-8[PubMed]
  • 7. Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res. 1996; 11(8): 1043-51[DOI][PubMed]
  • 8. Paganini-Hill A, Henderson VW. Estrogen deficiency and risk of Alzheimer's disease in women. Am J Epidemiol. 1994; 140(3): 256-61[PubMed]
  • 9. Wluka AE, Cicuttini FM, Spector TD. Menopause, oestrogens and arthritis. Maturitas. 2000; 35(3): 183-99[PubMed]
  • 10. Farrell E. Medical choices available for management of menopause. Best Pract Res Clin Endocrinol Metab. 2003; 17(1): 1-16[PubMed]
  • 11. Kim MJ, Park JH, Kwon DY, Yang HJ, Kim da S, Kang S, et al. The supplementation of Korean mistletoe water extracts reduces hot flushes, dyslipidemia, hepatic steatosis, and muscle loss in ovariectomized rats. Exp Biol Med (Maywood). 2015; 240(4): 477-87[DOI][PubMed]
  • 12. Kaume L, Gilbert WC, Brownmiller C, Howard LR, Devareddy L. Cyanidin 3-O-β-d-glucoside-rich blackberries modulate hepatic gene expression, and anti-obesity effects in ovariectomized rats. Journal of Functional Foods. 2012; 4(2): 480-8
  • 13. Prasannarong M, Saengsirisuwan V, Piyachaturawat P, Suksamrarn A. Improvements of insulin resistance in ovariectomized rats by a novel phytoestrogen from Curcuma comosa Roxb. BMC Complement Altern Med. 2012; 12: 28[DOI][PubMed]
  • 14. Ghorbani A, Hadjzadeh MA, Rajaei Z, Zendehbad SB. Effects of fenugreek seeds on adipogenesis and lipolysis in normal and diabetic rats. Pak J Biol Sci. 2014; 17(4): 523-8[PubMed]
  • 15. Ghorbani A. Phytotherapy for diabetic dyslipidemia: evidence from clinical trials. Clinical Lipidology. 2013; 8(3): 311-9
  • 16. Bin-Hafeez B, Haque R, Parvez S, Pandey S, Sayeed I, Raisuddin S. Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice. Int Immunopharmacol. 2003; 3(2): 257-65[DOI][PubMed]
  • 17. Vyas S, Agrawal RP, Solanki P, Trivedi P. Analgesic and anti-inflammatory activities of Trigonella foenum-graecum (seed) extract. Acta Pol Pharm. 2008; 65(4): 473-6[PubMed]
  • 18. Mandegary A, Pournamdari M, Sharififar F, Pournourmohammadi S, Fardiar R, Shooli S. Alkaloid and flavonoid rich fractions of fenugreek seeds (Trigonella foenum-graecum L.) with antinociceptive and anti-inflammatory effects. Food Chem Toxicol. 2012; 50(7): 2503-7[DOI][PubMed]
  • 19. Sindhu G, Ratheesh M, Shyni GL, Nambisan B, Helen A. Anti-inflammatory and antioxidative effects of mucilage of Trigonella foenum graecum (Fenugreek) on adjuvant induced arthritic rats. Int Immunopharmacol. 2012; 12(1): 205-11[DOI][PubMed]
  • 20. Hakimi S, Mohammad Alizadeh S, Delazar A, Abbasalizadeh F, Bamdad Mogaddam R, Siiahi MR, et al. Probable effects of fenugreek seed on hot flash in menopausal women. Journal of Medicinal Plants. 2006; 3(19): 9-14
  • 21. Nasri S, Abedinzade M, Jamal Omidi M, Noursabaghi F. Comparison of Analgesic and Hypoglycemic Effect of Hexanic and Alcohlic Extract of Fenugreek Seed in Male Diabetic Rats. Journal of Ardabil University of Medical Sciences. 2013; 13(1): 102-9
  • 22. Shafiee-Nick R, Ghorbani A, Vafaee Bagheri F, Rakhshandeh H. Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Adv Pharmacol Sci. 2012; 2012: 789796[DOI][PubMed]
  • 23. Field KJ, White WJ, Lang CM. Anaesthetic effects of chloral hydrate, pentobarbitone and urethane in adult male rats. Lab Anim. 1993; 27(3): 258-69[PubMed]
  • 24. Abbas AM, Elsamanoudy AZ. Effects of 17beta-estradiol and antioxidant administration on oxidative stress and insulin resistance in ovariectomized rats. Can J Physiol Pharmacol. 2011; 89(7): 497-504[DOI][PubMed]
  • 25. Ryou SH, Kang MS, Kim KI, Kang YH, Kang JS. Effects of green tea or Sasa quelpaertensis bamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats. Nutr Res Pract. 2012; 6(2): 106-12[DOI][PubMed]
  • 26. Cheng PY, Lee YM, Yen MH, Peng JC, Lam KK. Reciprocal effects of alpha-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats. Menopause. 2011; 18(9): 1010-7[DOI][PubMed]
  • 27. Ghorbani A. Best herbs for managing diabetes: a review of clinical studies. Brazilian Journal of Pharmaceutical Sciences. 2013; 49(3): 413-22
  • 28. Vijayakumar MV, Bhat MK. Hypoglycemic effect of a novel dialysed fenugreek seeds extract is sustainable and is mediated, in part, by the activation of hepatic enzymes. Phytother Res. 2008; 22(4): 500-5[DOI][PubMed]
  • 29. Hannan JM, Ali L, Rokeya B, Khaleque J, Akhter M, Flatt PR, et al. Soluble dietary fibre fraction of Trigonella foenum-graecum (fenugreek) seed improves glucose homeostasis in animal models of type 1 and type 2 diabetes by delaying carbohydrate digestion and absorption, and enhancing insulin action. Br J Nutr. 2007; 97(3): 514-21[DOI][PubMed]
  • 30. Handa T, Yamaguchi K, Sono Y, Yazawa K. Effects of fenugreek seed extract in obese mice fed a high-fat diet. Biosci Biotechnol Biochem. 2005; 69(6): 1186-8[DOI][PubMed]
  • 31. Al-Matubsi HY, Nasrat NA, Oriquat GA, Abu-Samak M, Al-Mzain KA, Salim M. The hypocholesterolemic and antioxidative effect of dietary diosgenin and chromium chloride supplementation on high-cholesterol fed Japanese quails. Pak J Biol Sci. 2011; 14(7): 425-32[PubMed]
  • 32. Bismar H, Diel I, Ziegler R, Pfeilschifter J. Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of estrogen replacement. J Clin Endocrinol Metab. 1995; 80(11): 3351-5[DOI][PubMed]
  • 33. Pfeilschifter J, Koditz R, Pfohl M, Schatz H. Changes in proinflammatory cytokine activity after menopause. Endocr Rev. 2002; 23(1): 90-119[DOI][PubMed]
  • 34. Sreeja S, Anju VS, Sreeja S. In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds. Indian J Med Res. 2010; 131: 814-9[PubMed]
  • 35. Raju J, Rao CV. Bioactive Compounds in Phytomedicine. 2011; : 125
  • 36. Uemura T, Hirai S, Mizoguchi N, Goto T, Lee JY, Taketani K, et al. Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues. Mol Nutr Food Res. 2010; 54(11): 1596-608[DOI][PubMed]
  • 37. Joshi DV, Patil RR, Naik SR. Hydroalcohol extract of Trigonella foenum-graecum seed attenuates markers of inflammation and oxidative stress while improving exocrine function in diabetic rats. Pharm Biol. 2015; 53(2): 201-11[DOI][PubMed]
  • 38. Ryan AS, Nicklas BJ. Reductions in plasma cytokine levels with weight loss improve insulin sensitivity in overweight and obese postmenopausal women. Diabetes Care. 2004; 27(7): 1699-705[PubMed]
  • 39. Seidel V. Natural product isolation. 2006; : 27-46
  • 40. Ciftci ON, Przybylski R, Rudzinska M, Acharya S. Characterization of Fenugreek (Trigonella foenum-graecum) Seed Lipids. Journal of the American Oil Chemists' Society. 2011; 88(10): 1603-10
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments