Iranian Red Crescent Medical Journal

Published by: Kowsar

Pseudo-Foster Kennedy Syndrome as a Rare Presentation of Vitamin B12 Deficiency

Peyman Petramfar 1 , Farideh Hosseinzadeh 2 and S. Saeed Mohammadi 2 , *
Authors Information
1 Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: June 01, 2016, 18 (6); e24610
  • Published Online: May 14, 2016
  • Article Type: Case Report
  • Received: October 18, 2014
  • Revised: March 30, 2015
  • Accepted: April 18, 2015
  • DOI: 10.5812/ircmj.24610

To Cite: Petramfar P, Hosseinzadeh F, Mohammadi S S. Pseudo-Foster Kennedy Syndrome as a Rare Presentation of Vitamin B12 Deficiency, Iran Red Crescent Med J. 2016 ; 18(6):e24610. doi: 10.5812/ircmj.24610.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Kennedy F. Retrobulbar neuritis as an exact diagnostic sign of certain tumors and abscesses in the frontal lobes. Am. J. Med. Sci. 1911; 142(3): 355-68
  • 2. Kennedy F. A further note on the diagnostic value of retrobulbar neuritis in expanding lesions of the frontal lobes: with a report of this syndrome in a case of aneurysm of the right internal carotid artery. J. Am. Med. Assoc. 1916; 67(19): 1361-3
  • 3. Gelwan MJ, Seidman M, Kupersmith MJ. Pseudo-pseudo-Foster Kennedy syndrome. J Clin Neuroophthalmol. 1988; 8(1): 49-52[PubMed]
  • 4. Watnick RL, Trobe JD. Bilateral optic nerve compression as a mechanism for the Foster Kennedy syndrome. Ophthalmology. 1989; 96(12): 1793-8[PubMed]
  • 5. Schatz NJ, Smith JL. Non-tumor causes of the Foster Kennedy syndrome. J Neurosurg. 1967; 27(1): 37-44[DOI][PubMed]
  • 6. Weir DG, Scott JM. Brain function in the elderly: role of vitamin B12 and folate. Br Med Bull. 1999; 55(3): 669-82[PubMed]
  • 7. Saperstein DS, Barohn R. Peripheral neuropathy due to cobalamin deficiency. Curr Treat Options Neurol. 2002; 4(3): 197-201[DOI]
  • 8. Beck RW. The optic neuritis treatment trial: three-year follow-up results. Arch Ophthalmol. 1995; 113(2): 136-7[PubMed]
  • 9. Pianka P, Almog Y, Man O, Goldstein M, Sela BA, Loewenstein A. Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. Ophthalmology. 2000; 107(8): 1588-92[PubMed]
  • 10. Petzold A, Plant GT. Diagnosis and classification of autoimmune optic neuropathy. Autoimmun Rev. 2014; 13(4-5): 539-45[DOI][PubMed]
  • 11. Frohman L, Turbin R, Bielory L, Wolansky L, Lambert WC, Cook S. Autoimmune optic neuropathy with anticardiolipin antibody mimicking multiple sclerosis in a child. Am J Ophthalmol. 2003; 136(2): 358-60[PubMed]
  • 12. Beck RW, Trobe JD, Moke PS, Gal RL, Xing D, Bhatti MT, et al. High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial. Arch Ophthalmol. 2003; 121(7): 944-9[DOI][PubMed]
  • 13. Bulters DO, Shenouda E, Evans BT, Mathad N, Lang DA. Visual recovery following optic nerve decompression for chronic compressive neuropathy. Acta Neurochir (Wien). 2009; 151(4): 325-34[DOI][PubMed]
  • 14. Kerrison JB. Latent, acute, and chronic Leber's hereditary optic neuropathy. Ophthalmology. 2005; 112(1): 1-2[DOI][PubMed]
  • 15. Barboni P, Savini G, Valentino ML, Montagna P, Cortelli P, De Negri AM, et al. Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy. Ophthalmology. 2005; 112(1): 120-6[DOI][PubMed]
  • 16. Newman NJ. Leber hereditary optic neuropathy: some new observations. J Neuroophthalmol. 2011; 31(1): 3-5[DOI][PubMed]
  • 17. Hsu CT, Miller NR, Wray ML. Optic neuropathy from folic acid deficiency without alcohol abuse. Ophthalmologica. 2002; 216(1): 65-7[DOI][PubMed]
  • 18. Grzybowski A. Problems related to the diagnosis of vitamin B12 deficiency optic neuropathy. Acta Ophthalmol. 2014; 92(1)-5[DOI][PubMed]
  • 19. Scalabrino G. The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: Lessons learned from its deficiency. Prog Neurobiol. 2009; 88(3): 203-20[DOI][PubMed]
  • 20. Larner AJ. Visual failure caused by vitamin B12 deficiency optic neuropathy. Int J Clin Pract. 2004; 58(10): 977-8[PubMed]
  • 21. Nicholls P. Formate as an inhibitor of cytochrome c oxidase. Biochem Biophys Res Commun. 1975; 67(2): 610-6[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments