Iranian Red Crescent Medical Journal

Published by: Kowsar

Extreme Thrombocytosis Presenting in Anti-Neutrophil Cytoplasmic Autoantibodies-Associated Crescentic Glomerulonephritis with Immune Complex Deposits: A Case Report

Zhang Xuemei 1 , Diao Yongshu 1 , Zhang Ling 1 , Yang Yingying 1 and Fu Ping 1 , *
Authors Information
1 Division of Nephrology, West China Hospital, Sichuan University, Chengdu, China
Article information
  • Iranian Red Crescent Medical Journal: October 01, 2016, 18 (10); e23272
  • Published Online: April 25, 2016
  • Article Type: Case Report
  • Received: September 3, 2014
  • Revised: November 16, 2014
  • Accepted: March 20, 2015
  • DOI: 10.5812/ircmj.23272v2

To Cite: Xuemei Z, Yongshu D, Ling Z, Yingying Y, Ping F. Extreme Thrombocytosis Presenting in Anti-Neutrophil Cytoplasmic Autoantibodies-Associated Crescentic Glomerulonephritis with Immune Complex Deposits: A Case Report, Iran Red Crescent Med J. 2016 ; 18(10):e23272. doi: 10.5812/ircmj.23272v2.

Copyright © 2016, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, et al. Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert panel. Blood. 2007; 110(4): 1092-7[DOI][PubMed]
  • 2. Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013; 65(1): 1-11[DOI][PubMed]
  • 3. Ohhashi J, Miyamoto M, Ishikawa S, Hashizume Y, Nishido T, Matsuyama K, et al. Crescentic glomerulonephritis with positive antineutrophil cytoplasmic autoantibody specific for myeloperoxidase associated with autoimmune hemolytic anemia and thrombocytopenic purpura. Intern Med. 2000; 39(8): 650-4[PubMed]
  • 4. Sumida K, Ubara Y, Nomura K, Hoshino J, Suwabe T, Hiramatsu R, et al. ANCA-associated crescentic glomerulonephritis with immune complex deposits. Clin Nephrol. 2012; 77(6): 454-60[PubMed]
  • 5. Sutor AH. Thrombocytosis in childhood. Semin Thromb Hemost. 1995; 21(3): 330-9[DOI][PubMed]
  • 6. Yadav D, Chandra J, Sharma S, Singh V. Clinicohematological study of thrombocytosis. Indian J Pediatr. 2010; 77(6): 643-7[DOI][PubMed]
  • 7. Haidopoulou K, Goutaki M, Lemonaki M, Kavga M, Papa A. Reactive thrombocytosis in children with viral respiratory tract infections. Minerva Pediatr. 2011; 63(4): 257-62[PubMed]
  • 8. Wang JL, Huang LT, Wu KH, Lin HW, Ho MY, Liu HE. Associations of reactive thrombocytosis with clinical characteristics in pediatric diseases. Pediatr Neonatol. 2011; 52(5): 261-6[DOI][PubMed]
  • 9. Williams B, Morton C. Cerebral vascular accident in a patient with reactive thrombocytosis: a rare cause of stroke. Am J Med Sci. 2008; 336(3): 279-81[DOI][PubMed]
  • 10. Wang Y, Zhao MH, Yu J, Xin G, Liu YC, Zhang YK, et al. The clinical and pathological characteristics of Chinese elderly patients with anti-neutrophil cytoplasmic autoantibodies associated small vessel vasculitis. Exp Gerontol. 2004; 39(9): 1401-5[DOI][PubMed]
  • 11. Agrawal V, Vaidya CK, Ye J, Freeman J, McKiernan C, Blier PR, et al. Concomitant thrombotic thrombocytopenic purpura and ANCA-associated vasculitis in an adolescent. Pediatr Nephrol. 2011; 26(8): 1317-20[DOI][PubMed]
  • 12. Haas M, Eustace JA. Immune complex deposits in ANCA-associated crescentic glomerulonephritis: a study of 126 cases. Kidney Int. 2004; 65(6): 2145-52[PubMed]
  • 13. Neumann I, Regele H, Kain R, Birck R, Meisl FT. Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis. Nephrol Dial Transplant. 2003; 18(3): 524-31[PubMed]
  • 14. Yoshida M, Saiga K, Hato T, Iwaki S, Niiya T, Arita N, et al. Cappuccino mutation in an autoimmune-prone strain of mice suggests a role of platelet function in the progression of immune complex crescentic glomerulonephritis. Arthritis Rheum. 2006; 54(9): 2934-43[DOI][PubMed]
  • 15. Hohenstein B, Daniel C, Johnson RJ, Amann KU, Hugo CP. Platelets are not critical effector cells for the time course of murine passive crescentic glomerulonephritis. Platelets. 2013; 24(4): 267-74[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments