Iranian Red Crescent Medical Journal

Published by: Kowsar

An Experimental Study: Does the Neuroprotective Effect Increase When Hypothermia Deepens After Traumatic Brain Injury?

Abdullah Sadik Girisgin 1 , * , Erdal Kalkan 2 , Mehmet Ergin 1 , Fatih Keskin 2 , Zerrin Defne Dundar 1 , Sedat Kebapcioglu 3 , Sedat Kocak 1 and Basar Cander 1
Authors Information
1 Department of Emergency Medicine, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Turkey
2 Department of Neurosurgery, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Turkey
3 Department of Emergency Medicine, Medicine Faculty, Mevlana University, Konya, Turkey
Article information
  • Iranian Red Crescent Medical Journal: April 01, 2015, 17 (4); e21233
  • Published Online: April 25, 2015
  • Article Type: Research Article
  • Received: June 18, 2014
  • Revised: October 16, 2014
  • Accepted: November 9, 2014
  • DOI: 10.5812/ircmj.17(4)2015.21233

To Cite: Girisgin A S, Kalkan E, Ergin M, Keskin F, Dundar Z D, et al. An Experimental Study: Does the Neuroprotective Effect Increase When Hypothermia Deepens After Traumatic Brain Injury?, Iran Red Crescent Med J. 2015 ; 17(4):e21233. doi: 10.5812/ircmj.17(4)2015.21233.

Abstract
Copyright © 2015, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
Footnote
References
  • 1. Georgoff P, Meghan S, Mirza K, Stein SC. Geographic variation in outcomes from severe traumatic brain injury. World Neurosurg. 2010; 74(2-3): 331-45[DOI][PubMed]
  • 2. World Health Organization . World report on road traffic injury prevention: summary. 2004;
  • 3. Hofman K, Primack A, Keusch G, Hrynkow S. Addressing the growing burden of trauma and injury in low- and middle-income countries. Am J Public Health. 2005; 95(1): 13-7[DOI][PubMed]
  • 4. Chio CC, Kuo JR, Hsiao SH, Chang CP, Lin MT. Effect of brain cooling on brain ischemia and damage markers after fluid percussion brain injury in rats. Shock. 2007; 28(3): 284-90[DOI][PubMed]
  • 5. Kuo JR, Lo CJ, Chang CP, Lin MT, Chio CC. Attenuation of brain nitrostative and oxidative damage by brain cooling during experimental traumatic brain injury. J Biomed Biotechnol. 2011; 2011: 145214[DOI][PubMed]
  • 6. Celik SE, Ozturk H, Tolunay S. Therapeutic effect of hypothermia and dizocilpine maleate on traumatic brain injury in neonatal rats. J Neurotrauma. 2006; 23(9): 1355-65[DOI][PubMed]
  • 7. Lee HC, Chuang HC, Cho DY, Cheng KF, Lin PH, Chen CC. Applying cerebral hypothermia and brain oxygen monitoring in treating severe traumatic brain injury. World Neurosurg. 2010; 74(6): 654-60[DOI][PubMed]
  • 8. Sydenham E, Roberts I, Alderson P. Hypothermia for traumatic head injury. Cochrane Database Syst Rev. 2009; (2)[DOI][PubMed]
  • 9. Clifton GL, Valadka A, Zygun D, Coffey CS, Drever P, Fourwinds S, et al. Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial. Lancet Neurol. 2011; 10(2): 131-9[DOI][PubMed]
  • 10. Maas A, Stocchetti N. Hypothermia and the complexity of trials in patients with traumatic brain injury. Lancet Neurol. 2011; 10(2): 111-3[DOI][PubMed]
  • 11. Reynolds JC, Rittenberger JC, Menegazzi JJ. Drug administration in animal studies of cardiac arrest does not reflect human clinical experience. Resuscitation. 2007; 74(1): 13-26[DOI][PubMed]
  • 12. Baker CJ, Fiore AJ, Frazzini VI, Choudhri TF, Zubay GP, Solomon RA. Intraischemic hypothermia decreases the release of glutamate in the cores of permanent focal cerebral infarcts. Neurosurgery. 1995; 36(5): 994-1001[PubMed]
  • 13. Busto R, Dietrich WD, Globus MY, Valdes I, Scheinberg P, Ginsberg MD. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab. 1987; 7(6): 729-38[DOI][PubMed]
  • 14. Marmarou A, Lu J, Butcher I, McHugh GS, Mushkudiani NA, Murray GD, et al. IMPACT database of traumatic brain injury: design and description. J Neurotrauma. 2007; 24(2): 239-50[DOI][PubMed]
  • 15. DeKosky ST, Abrahamson EE, Taffe KM, Dixon CE, Kochanek PM, Ikonomovic MD. Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies. J Neurochem. 2004; 90(4): 998-1004[DOI][PubMed]
  • 16. Kuo JR, Lo CJ, Chang CP, Lin HJ, Lin MT, Chio CC. Brain cooling-stimulated angiogenesis and neurogenesis attenuated traumatic brain injury in rats. J Trauma. 2010; 69(6): 1467-72[DOI][PubMed]
  • 17. Doll H, Truebel H, Kipfmueller F, Schaefer U, Neugebauer EA, Wirth S, et al. Pharyngeal selective brain cooling improves neurofunctional and neurocognitive outcome after fluid percussion brain injury in rats. J Neurotrauma. 2009; 26(2): 235-42[DOI][PubMed]
  • 18. Doll H, Maegele M, Bohl J, Storkel S, Kipfmueller F, Schaefer U, et al. Pharyngeal selective brain cooling is associated with reduced CNS cortical lesion after experimental traumatic brain injury in rats. J Neurotrauma. 2010; 27(12): 2245-54[DOI][PubMed]
  • 19. Hsu SF, Niu KC, Lin CL, Lin MT. Brain cooling causes attenuation of cerebral oxidative stress, systemic inflammation, activated coagulation, and tissue ischemia/injury during heatstroke. Shock. 2006; 26(2): 210-20[DOI][PubMed]
  • 20. Laptook AR, Corbett RJ, Burns D, Sterett R. Neonatal ischemic neuroprotection by modest hypothermia is associated with attenuated brain acidosis. Stroke. 1995; 26(7): 1240-6[PubMed]
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