Iranian Red Crescent Medical Journal

Published by: Kowsar

Wound Healing Activity of a Traditionally Used Poly Herbal Product in a Burn Wound Model in Rats

Shirin Fahimi 1 , Mohammad Abdollahi 2 , Seyed Alireza Mortazavi 3 , Homa Hajimehdipoor 1 , * , Amir Hossein Abdolghaffari 4 , 5 and Mohammad Amin Rezvanfar 2
Authors Information
1 Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
2 Department of Toxicology and Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IR Iran
3 Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
4 Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, IR Iran
5 International Campus, ICTUMS, Tehran University of Medical Sciences, Tehran, IR Iran
Article information
  • Iranian Red Crescent Medical Journal: September 01, 2015, 17 (9); e19960
  • Published Online: September 22, 2015
  • Article Type: Research Article
  • Received: May 4, 2014
  • Revised: May 25, 2015
  • Accepted: July 6, 2015
  • DOI: 10.5812/ircmj.19960

To Cite: Fahimi S, Abdollahi M, Mortazavi S A, Hajimehdipoor H, Abdolghaffari A H, et al. Wound Healing Activity of a Traditionally Used Poly Herbal Product in a Burn Wound Model in Rats, Iran Red Crescent Med J. 2015 ; 17(9):e19960. doi: 10.5812/ircmj.19960.

Copyright © 2015, Iranian Red Crescent Medical Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Ezzati A, Bayat M, Taheri S, Mohsenifar Z. Low-level laser therapy with pulsed infrared laser accelerates third-degree burn healing process in rats. J Rehabil Res Dev. 2009; 46(4): 543-54[PubMed]
  • 2. Upadhyay NK, Kumar R, Siddiqui MS, Gupta A. Mechanism of Wound-Healing Activity of Hippophae rhamnoides L. Leaf Extract in Experimental Burns. Evid Based Complement Alternat Med. 2011; 2011: 659705[DOI][PubMed]
  • 3. Khorasani G, Hosseinimehr SJ, Zamani P, Ghasemi M, Ahmadi A. The effect of saffron(Crocus sativus) extract for healing of second-degree burn wounds in rats. Keio J Med. 2008; 57(4): 190-5[PubMed]
  • 4. Chaudhari M, Mengi S. Evaluation of phytoconstituents of Terminalia arjuna for wound healing activity in rats. Phytother Res. 2006; 20(9): 799-805[DOI][PubMed]
  • 5. The Canon of Medicine 2005;
  • 6. Jorjani SE. Zakhirah-i Khvarazm'Shahi. 1976;
  • 7. Aghili Shirazi MH. Moalejat-e-Aghili. 2008;
  • 8. Barros L, Carvalho AM, Ferreira IC. Leaves, flowers, immature fruits and leafy flowered stems of Malva sylvestris: a comparative study of the nutraceutical potential and composition. Food Chem Toxicol. 2010; 48(6): 1466-72[DOI][PubMed]
  • 9. Gasparetto JC, Martins CA, Hayashi SS, Otuky MF, Pontarolo R. Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. J Pharm Pharmacol. 2012; 64(2): 172-89[DOI][PubMed]
  • 10. Aghili Shirazi MH. Makhzan-ul-Adviah. 2008;
  • 11. Al Havi (Liber Continent) 2005;
  • 12. Heo KS, Lee SJ, Lim KT. Cytotoxic effect of glycoprotein isolated from Solanum nigrum L. through the inhibition of hydroxyl radical-induced DNA-binding activities of NF-kappa B in HT-29 cells. Environ Toxicol Pharmacol. 2004; 17(1): 45-54[DOI][PubMed]
  • 13. Abas F, Lajis NH, Israf DA, Khozirah S, Umi Kalsom Y. Antioxidant and nitric oxide inhibition activities of selected Malay traditional vegetables. Food Chem. 2006; 95(4): 566-73[DOI]
  • 14. al-Baitar I. al-jāmi li-mufradāt al-adwiyawa al-aghdhiya. 1st edTehran: Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine; 2008;
  • 15. Shamspur T, Mohamadi M, Mostafavi A. The effects of onion and salt treatments on essential oil content and composition of Rosa damascena Mill. Ind Crops Prod. 2012; 37(1): 451-6[DOI]
  • 16. Boskabady MH, Kiani S, Rakhshandah H. Relaxant effects of Rosa damascena on guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol. 2006; 106(3): 377-82[DOI][PubMed]
  • 17. Aghili Shirazi MH. Qarabadin-e-Kabir. 2011;
  • 18. Britsh Pharmacopoeia. 2011;
  • 19. Hajimehdipoor H, Esmaeili S, Shekarchi M, Emrarian T, Naghibi F. Investigation of some biologic activities of Swertia longifolia Boiss. Res Pharm Sci. 2013; 8(4): 253-9[PubMed]
  • 20. Bondet V, Brand-Williams W, Berset C. Kinetics and Mechanisms of Antioxidant Activity using the DPPH.Free Radical Method. LWT - Food Sci Technol. 1997; 30(6): 609-15[DOI]
  • 21. Hajimehdipoor H, Naghibi F, Bandidarian A, Moazzeni Zehan H, Pirani A, Hamzeloo- Moghadam M. Evaluating the antioxidant and acetylcholinesterase inhibitory activity of three Centaurea species. Res J Pharmacog. 2014; 1: 33-7
  • 22. Soberón JR, Sgariglia MA, Sampietro DA, Quiroga EN, Vattuone MA. Antibacterial activity of plant extracts from northwestern Argentina. J Appl Microbiol. 2007; 102(6): 1450-61[DOI][PubMed]
  • 23. Kahkeshani N, Farahanikia B, Mahdaviani P, Abdolghaffari A, Hassanzadeh G, Abdollahi M, et al. Antioxidant and burn healing potential of Galium odoratum extracts. Res Pharm Sci. 2013; 8(3): 197-203[PubMed]
  • 24. Ghosh S, Samanta A, Mandal NB, Bannerjee S, Chattopadhyay D. Evaluation of the wound healing activity of methanol extract of Pedilanthus tithymaloides (L.) Poit leaf and its isolated active constituents in topical formulation. J Ethnopharmacol. 2012; 142(3): 714-22[DOI][PubMed]
  • 25. Nayak BS, Pinto Pereira LM. Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats. BMC Complement Altern Med. 2006; 6: 41[DOI][PubMed]
  • 26. Li A, Zhang Y, Lao L, Xin J, Ren K, Berman BM, et al. Serotonin Receptor 2A/C Is Involved in Electroacupuncture Inhibition of Pain in an Osteoarthritis Rat Model. Evid Based Complement Alternat Med. 2011; 2011: 619650[DOI][PubMed]
  • 27. Thang PT, Patrick S, Teik LS, Yung CS. Anti-oxidant effects of the extracts from the leaves of Chromolaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine-xanthine oxidase induced damage. Burns. 2001; 27(4): 319-27[PubMed]
  • 28. Oberyszyn TM. Inflammation and wound healing. Front Biosci. 2007; 12(8-12): 2993-9[DOI]
  • 29. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007; 127(3): 514-25[DOI][PubMed]
  • 30. Nonato FR, Santana DG, de Melo FM, dos Santos GG, Brustolim D, Camargo EA, et al. Anti-inflammatory properties of rose oxide. Int Immunopharmacol. 2012; 14(4): 779-84[DOI][PubMed]
  • 31. Chandran PK, Kuttan R. Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns. J Clin Biochem Nutr. 2008; 43(2): 58-64[DOI][PubMed]
  • 32. Annan K, Houghton PJ. Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana. J Ethnopharmacol. 2008; 119(1): 141-4[DOI][PubMed]
  • 33. Kumari P, Yadav P, Verma PR, Kumar S, Arya A. A review on wound healing properties of Indian medicinal plants. Ind J Fund Appl Life Sci. 2013; 3(1): 220-32
  • 34. El SN, Karakaya S. Radical scavenging and iron-chelating activities of some greens used as traditional dishes in Mediterranean diet. Int J Food Sci Nutr. 2004; 55(1): 67-74[DOI][PubMed]
  • 35. Conforti F, Sosa S, Marrelli M, Menichini F, Statti GA, Uzunov D, et al. In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants. J Ethnopharmacol. 2008; 116(1): 144-51[DOI][PubMed]
  • 36. Quave CL, Plano LR, Pantuso T, Bennett BC. Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant Staphylococcus aureus. J Ethnopharmacol. 2008; 118(3): 418-28[DOI][PubMed]
  • 37. de Souza GC, Haas AP, von Poser GL, Schapoval EE, Elisabetsky E. Ethnopharmacological studies of antimicrobial remedies in the south of Brazil. J Ethnopharmacol. 2004; 90(1): 135-43[PubMed]
  • 38. Jimoh FO, Adedapo AA, Afolayan AJ. Comparison of the nutritional value and biological activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus. Food Chem Toxicol. 2010; 48(3): 964-71[DOI][PubMed]
  • 39. Yassa N, Masoomi F, Rohani Rankouhi SE, Hadjiakhoondi A. Chemical Composition and Antioxidant Activity of the Extract and Essential oil of Rosa damascena from Iran, Population of Guilan. DARU. 2009; 17(3): 175-80
  • 40. ozkan G. Note: Antioxidant and Antibacterial Activities of Rosa Damascena Flower Extracts. Food Sci Technol Int. 2004; 10(4): 277-81[DOI]
  • 41. Baydar NG, Baydar H. Phenolic compounds, antiradical activity and antioxidant capacity of oil-bearing rose (Rosa damascena Mill.) extracts. Ind Crops Prod. 2013; 41: 375-80[DOI]
  • 42. Hajhashemi V, Ghannadi A, Hajiloo M. Analgesic and Anti-inflammatory Effects of Rosa damascena Hydroalcoholic Extract and its Essential Oil in Animal Models. Iran J Pharm Res. 2010; 9(2): 163-8[PubMed]
  • 43. Proestos C, Boziaris IS, Nychas GJE, Komaitis M. Analysis of flavonoids and phenolic acids in Greek aromatic plants: Investigation of their antioxidant capacity and antimicrobial activity. Food Chem. 2006; 95(4): 664-71[DOI]
  • 44. Moreno S, Scheyer T, Romano CS, Vojnov AA. Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition. Free Radic Res. 2006; 40(2): 223-31[DOI][PubMed]
  • 45. Seeram NP, Adams LS, Henning SM, Niu Y, Zhang Y, Nair MG, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem. 2005; 16(6): 360-7[DOI][PubMed]
  • 46. Heinonen M. Antioxidant activity and antimicrobial effect of berry phenolics--a Finnish perspective. Mol Nutr Food Res. 2007; 51(6): 684-91[DOI][PubMed]
  • 47. Hajimehdipoor H, Adib N, Khanavi M, Mobli M, Amin GR, Hamzeloo Moghadam M. Comparative Study On The Effect Of Different Methods Of Drying On Phenolics Content And Antioxidant Activity of Some Edible Plants. Indian J Pharm Sci Res. 2012; 3(10)
  • 48. Rivera-Arce E, Chavez-Soto MA, Herrera-Arellano A, Arzate S, Aguero J, Feria-Romero IA, et al. Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment. J Ethnopharmacol. 2007; 109(3): 523-8[DOI][PubMed]
  • 49. Mendonca FA, Passarini Junior JR, Esquisatto MA, Mendonca JS, Franchini CC, Santos GM. Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in Wistar rats. Acta Cir Bras. 2009; 24(2): 150-5[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments